Incidental Mutation 'IGL02168:Ankra2'
ID 282803
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ankra2
Ensembl Gene ENSMUSG00000021661
Gene Name ankyrin repeat family A member 2
Synonyms
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.275) question?
Stock # IGL02168
Quality Score
Status
Chromosome 13
Chromosomal Location 98399584-98411262 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 98409882 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022164] [ENSMUST00000091356] [ENSMUST00000123924] [ENSMUST00000150352] [ENSMUST00000150916] [ENSMUST00000226100]
AlphaFold Q99PE2
Predicted Effect probably benign
Transcript: ENSMUST00000022164
SMART Domains Protein: ENSMUSP00000022164
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 180 209 1.45e-6 SMART
ANK 213 242 1.05e-3 SMART
ANK 246 275 1.76e-5 SMART
Blast:ANK 279 308 1e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000091356
SMART Domains Protein: ENSMUSP00000088915
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 20 49 1.45e-6 SMART
ANK 53 82 1.05e-3 SMART
ANK 86 115 1.76e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123924
SMART Domains Protein: ENSMUSP00000122701
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 180 209 1.45e-6 SMART
ANK 213 242 1.05e-3 SMART
ANK 246 275 1.76e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150352
SMART Domains Protein: ENSMUSP00000117508
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 180 209 1.45e-6 SMART
ANK 213 242 1.05e-3 SMART
ANK 246 275 1.76e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150916
SMART Domains Protein: ENSMUSP00000116590
Gene: ENSMUSG00000021661

DomainStartEndE-ValueType
ANK 20 49 1.45e-6 SMART
ANK 53 82 1.05e-3 SMART
ANK 86 115 1.76e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155629
Predicted Effect probably benign
Transcript: ENSMUST00000226100
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(3) : Targeted(2) Gene trapped(1)

Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010007H06Rik T C 9: 51,191,801 (GRCm39) probably benign Het
6030468B19Rik T A 11: 117,689,244 (GRCm39) probably benign Het
Astn1 C A 1: 158,436,911 (GRCm39) A823E possibly damaging Het
Cfap43 T C 19: 47,740,362 (GRCm39) probably benign Het
Clec4b2 T A 6: 123,181,156 (GRCm39) N180K probably damaging Het
Col7a1 A G 9: 108,813,143 (GRCm39) probably benign Het
Dhrs7c T C 11: 67,706,693 (GRCm39) F284L probably benign Het
Dock1 T C 7: 134,678,860 (GRCm39) probably benign Het
Entpd5 A T 12: 84,433,752 (GRCm39) probably null Het
Heatr5b A T 17: 79,139,020 (GRCm39) probably benign Het
Kdm3a A G 6: 71,577,101 (GRCm39) V738A probably damaging Het
Klf10 A T 15: 38,297,085 (GRCm39) F318L probably damaging Het
Mcc A C 18: 44,582,366 (GRCm39) I770S probably damaging Het
Muc19 C T 15: 91,778,292 (GRCm39) noncoding transcript Het
Or9a4 A T 6: 40,548,317 (GRCm39) probably benign Het
Pcdh17 A G 14: 84,770,635 (GRCm39) T1038A probably benign Het
Pole2 A G 12: 69,248,660 (GRCm39) probably benign Het
Polr2c A G 8: 95,584,394 (GRCm39) R36G probably damaging Het
Ptgs2 A G 1: 149,979,430 (GRCm39) probably null Het
Scart1 A T 7: 139,803,399 (GRCm39) H321L probably benign Het
Taf5 A G 19: 47,070,917 (GRCm39) D747G probably damaging Het
Tll1 T G 8: 64,507,001 (GRCm39) K580T possibly damaging Het
Tmc3 A T 7: 83,269,203 (GRCm39) N768I possibly damaging Het
Top1 G T 2: 160,546,893 (GRCm39) probably null Het
Ubtf T C 11: 102,204,994 (GRCm39) K97E probably damaging Het
Vcl T C 14: 21,057,355 (GRCm39) V509A probably benign Het
Vmn2r110 A T 17: 20,804,062 (GRCm39) probably benign Het
Zfp106 A G 2: 120,364,712 (GRCm39) V565A possibly damaging Het
Zfp458 A T 13: 67,406,098 (GRCm39) C111S probably damaging Het
Other mutations in Ankra2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02807:Ankra2 APN 13 98,408,250 (GRCm39) missense probably damaging 1.00
IGL03030:Ankra2 APN 13 98,409,881 (GRCm39) splice site probably benign
R0068:Ankra2 UTSW 13 98,409,891 (GRCm39) nonsense probably null
R0068:Ankra2 UTSW 13 98,409,891 (GRCm39) nonsense probably null
R0302:Ankra2 UTSW 13 98,408,200 (GRCm39) missense probably damaging 1.00
R0499:Ankra2 UTSW 13 98,402,962 (GRCm39) missense probably damaging 1.00
R0729:Ankra2 UTSW 13 98,408,235 (GRCm39) missense probably damaging 1.00
R1848:Ankra2 UTSW 13 98,407,632 (GRCm39) missense probably damaging 1.00
R2185:Ankra2 UTSW 13 98,402,912 (GRCm39) missense probably damaging 0.99
R2230:Ankra2 UTSW 13 98,407,646 (GRCm39) missense probably damaging 0.99
R2232:Ankra2 UTSW 13 98,407,646 (GRCm39) missense probably damaging 0.99
R3898:Ankra2 UTSW 13 98,410,317 (GRCm39) missense probably benign 0.13
R4605:Ankra2 UTSW 13 98,402,742 (GRCm39) intron probably benign
R4855:Ankra2 UTSW 13 98,409,919 (GRCm39) missense probably damaging 1.00
R5806:Ankra2 UTSW 13 98,405,005 (GRCm39) critical splice donor site probably null
R5901:Ankra2 UTSW 13 98,407,644 (GRCm39) missense probably damaging 0.99
R6478:Ankra2 UTSW 13 98,404,950 (GRCm39) missense probably damaging 1.00
R7469:Ankra2 UTSW 13 98,402,882 (GRCm39) missense probably benign 0.01
Z1177:Ankra2 UTSW 13 98,408,785 (GRCm39) missense possibly damaging 0.73
Posted On 2015-04-16