Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02172:Zfp874b'

282935

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp874b

Ensembl Gene

ENSMUSG00000059839

Gene Name

zinc finger protein 874b

Synonyms

9630025I21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

IGL02172

Quality Score

Status

Chromosome

Chromosomal Location

67619632-67632377 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 67622135 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 388 (Y388N)

Ref Sequence

ENSEMBL: ENSMUSP00000019572 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019572] [ENSMUST00000223868]

AlphaFold

Q7M6X2

Predicted Effect

probably damaging
Transcript: ENSMUST00000019572
AA Change: Y388N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000019572
Gene: ENSMUSG00000059839
AA Change: Y388N

Domain	Start	End	E-Value	Type
KRAB	5	65	4.48e-26	SMART
ZnF_C2H2	136	158	5.9e-3	SMART
ZnF_C2H2	164	186	3.16e-3	SMART
ZnF_C2H2	192	214	6.78e-3	SMART
ZnF_C2H2	220	242	2.4e-3	SMART
ZnF_C2H2	248	268	1.88e2	SMART
ZnF_C2H2	276	298	6.42e-4	SMART
ZnF_C2H2	304	326	2.12e-4	SMART
ZnF_C2H2	332	354	1.28e-3	SMART
ZnF_C2H2	360	382	8.47e-4	SMART
ZnF_C2H2	388	410	1.79e-2	SMART
ZnF_C2H2	416	438	1.47e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223711

Predicted Effect

probably benign
Transcript: ENSMUST00000223868

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223925

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224308

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225027

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	G	1: 71,341,817 (GRCm39)	V1048A	probably benign	Het
Adgre1	C	T	17: 57,785,879 (GRCm39)	T875I	probably damaging	Het
Arhgef26	T	C	3: 62,367,097 (GRCm39)	V810A	probably benign	Het
Atf1	T	A	15: 100,152,322 (GRCm39)	V105E	probably damaging	Het
Bbs9	C	T	9: 22,490,772 (GRCm39)	T300I	possibly damaging	Het
Bltp1	T	C	3: 37,059,022 (GRCm39)	V3236A	probably damaging	Het
Brd7	G	T	8: 89,078,452 (GRCm39)	H226Q	probably benign	Het
Cadps	T	C	14: 12,705,681 (GRCm38)	K238R	probably damaging	Het
Chordc1	A	G	9: 18,213,388 (GRCm39)	T80A	possibly damaging	Het
Clca4a	A	T	3: 144,676,155 (GRCm39)	C126*	probably null	Het
Col24a1	A	T	3: 145,020,723 (GRCm39)	T365S	probably benign	Het
Crb1	C	T	1: 139,164,965 (GRCm39)	G1053D	probably damaging	Het
Creb3l4	A	T	3: 90,150,082 (GRCm39)	S20T	probably benign	Het
Cyp2c67	C	T	19: 39,637,446 (GRCm39)	C10Y	possibly damaging	Het
Dhdh	A	T	7: 45,125,041 (GRCm39)	C294S	probably damaging	Het
Fam135a	A	G	1: 24,063,861 (GRCm39)		probably null	Het
Fsd1	G	T	17: 56,297,244 (GRCm39)		probably benign	Het
Gatad2b	A	G	3: 90,262,978 (GRCm39)		probably benign	Het
Glb1l2	T	C	9: 26,680,382 (GRCm39)	D232G	probably damaging	Het
Gm10553	T	C	1: 85,078,015 (GRCm39)	L44P	probably damaging	Het
Hecw1	T	C	13: 14,438,734 (GRCm39)	Y883C	probably damaging	Het
Helq	A	G	5: 100,938,013 (GRCm39)	F478L	probably damaging	Het
Ift172	T	C	5: 31,438,681 (GRCm39)		probably benign	Het
Krtcap3	A	C	5: 31,409,397 (GRCm39)	T55P	probably damaging	Het
Megf6	A	G	4: 154,355,149 (GRCm39)	D1488G	probably damaging	Het
Mrpl1	T	C	5: 96,379,574 (GRCm39)	V203A	probably damaging	Het
Myh2	A	T	11: 67,079,878 (GRCm39)	D1084V	possibly damaging	Het
Necap2	T	A	4: 140,805,621 (GRCm39)		probably benign	Het
Nemp1	A	G	10: 127,528,868 (GRCm39)	S191G	probably benign	Het
Nrip1	T	C	16: 76,088,380 (GRCm39)	D1059G	probably damaging	Het
Ntrk3	A	T	7: 78,110,020 (GRCm39)		probably benign	Het
Or51e1	G	A	7: 102,359,051 (GRCm39)	R195H	probably benign	Het
Or51f1d	A	G	7: 102,700,582 (GRCm39)	I26V	probably benign	Het
Prkdc	T	G	16: 15,627,623 (GRCm39)	V3427G	probably benign	Het
Ptprn2	A	T	12: 116,837,317 (GRCm39)		probably benign	Het
Ptprt	A	T	2: 161,397,422 (GRCm39)	L1095H	probably damaging	Het
Ren1	T	A	1: 133,286,771 (GRCm39)	L300Q	possibly damaging	Het
Rgl3	A	G	9: 21,888,134 (GRCm39)	I460T	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Runx1t1	A	C	4: 13,859,924 (GRCm39)	Q265P	probably benign	Het
Sh3d21	A	G	4: 126,046,153 (GRCm39)	S282P	probably benign	Het
Slc39a13	T	C	2: 90,893,505 (GRCm39)	E318G	possibly damaging	Het
Srd5a3	T	C	5: 76,295,556 (GRCm39)	I82T	probably benign	Het
Stard7	C	A	2: 127,132,792 (GRCm39)	T220N	probably damaging	Het
Tbx4	G	A	11: 85,805,389 (GRCm39)	G493R	possibly damaging	Het
Trerf1	A	T	17: 47,628,743 (GRCm39)		noncoding transcript	Het
Trim59	T	A	3: 68,944,810 (GRCm39)	I177L	probably benign	Het
Trpm7	T	C	2: 126,637,248 (GRCm39)	M1789V	possibly damaging	Het
Tsc22d1	T	C	14: 76,655,132 (GRCm39)	V455A	probably benign	Het
Vmn2r118	C	A	17: 55,931,598 (GRCm39)	M25I	probably benign	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Wdr90	G	A	17: 26,069,408 (GRCm39)	T1233I	probably benign	Het
Zcchc2	G	A	1: 105,928,664 (GRCm39)	D308N	probably benign	Het
Zfp57	G	T	17: 37,320,481 (GRCm39)	V112L	possibly damaging	Het

Other mutations in Zfp874b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0432:Zfp874b	UTSW	13	67,629,955 (GRCm39)	missense	probably damaging	1.00
R0653:Zfp874b	UTSW	13	67,623,052 (GRCm39)	missense	possibly damaging	0.69
R0727:Zfp874b	UTSW	13	67,622,831 (GRCm39)	missense	probably damaging	1.00
R1475:Zfp874b	UTSW	13	67,622,211 (GRCm39)	splice site	probably null
R1726:Zfp874b	UTSW	13	67,622,839 (GRCm39)	missense	probably damaging	1.00
R5484:Zfp874b	UTSW	13	67,629,373 (GRCm39)	missense	possibly damaging	0.76
R6386:Zfp874b	UTSW	13	67,622,962 (GRCm39)	missense	possibly damaging	0.70
R7029:Zfp874b	UTSW	13	67,622,392 (GRCm39)	missense	probably damaging	0.98
R7150:Zfp874b	UTSW	13	67,622,622 (GRCm39)	nonsense	probably null
R7726:Zfp874b	UTSW	13	67,621,975 (GRCm39)	missense	probably benign	0.01
R7778:Zfp874b	UTSW	13	67,622,093 (GRCm39)	missense	probably benign	0.03
R7824:Zfp874b	UTSW	13	67,622,093 (GRCm39)	missense	probably benign	0.03
R7918:Zfp874b	UTSW	13	67,622,279 (GRCm39)	missense	possibly damaging	0.74
R7939:Zfp874b	UTSW	13	67,622,622 (GRCm39)	nonsense	probably null
R8053:Zfp874b	UTSW	13	67,622,217 (GRCm39)	missense	probably damaging	0.96
R8881:Zfp874b	UTSW	13	67,622,141 (GRCm39)	missense	probably damaging	0.99
X0028:Zfp874b	UTSW	13	67,622,179 (GRCm39)	missense	probably damaging	0.96

Posted On

2015-04-16