Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02173:Dtx4'

282978

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dtx4

Ensembl Gene

ENSMUSG00000039982

Gene Name

deltex 4, E3 ubiquitin ligase

Synonyms

RNF155

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.462) question?

Stock #

IGL02173

Quality Score

Status

Chromosome

Chromosomal Location

12443702-12478818 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to T at 12450621 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 530 (Y530*)

Ref Sequence

ENSEMBL: ENSMUSP00000040229 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045521]

AlphaFold

Q6PDK8

Predicted Effect

probably null
Transcript: ENSMUST00000045521
AA Change: Y530*

SMART Domains

Protein: ENSMUSP00000040229
Gene: ENSMUSG00000039982
AA Change: Y530*

Domain	Start	End	E-Value	Type
WWE	5	86	1.38e-38	SMART
WWE	88	163	6.72e-28	SMART
low complexity region	175	192	N/A	INTRINSIC
low complexity region	372	386	N/A	INTRINSIC
RING	406	464	2.2e-6	SMART
Blast:RING	510	532	3e-7	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(1) : Gene trapped(1)

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	T	10: 87,061,754 (GRCm39)	H68L	possibly damaging	Het
4930533K18Rik	A	G	10: 70,708,060 (GRCm39)		noncoding transcript	Het
4933409G03Rik	A	G	2: 68,443,401 (GRCm39)	T182A	unknown	Het
Abca2	T	A	2: 25,331,909 (GRCm39)	D1340E	probably benign	Het
Abcc12	G	A	8: 87,293,071 (GRCm39)	A39V	probably damaging	Het
Acap2	T	C	16: 30,926,965 (GRCm39)	R510G	possibly damaging	Het
Ace	G	T	11: 105,879,817 (GRCm39)	R719L	probably benign	Het
Adarb1	A	C	10: 77,157,659 (GRCm39)	F263V	probably damaging	Het
Ahcyl	T	C	16: 45,974,441 (GRCm39)	N312S	probably benign	Het
Ambra1	T	C	2: 91,748,013 (GRCm39)	S1130P	probably benign	Het
Aqp7	A	T	4: 41,034,379 (GRCm39)	L260*	probably null	Het
Cntn5	G	T	9: 9,748,401 (GRCm39)	S493R	probably damaging	Het
Crhr2	A	G	6: 55,080,165 (GRCm39)	F138S	probably damaging	Het
D2hgdh	T	A	1: 93,757,611 (GRCm39)	D175E	probably benign	Het
Elp4	T	A	2: 105,533,088 (GRCm39)	H419L	probably damaging	Het
Etv6	A	G	6: 134,225,690 (GRCm39)	D218G	possibly damaging	Het
Exoc5	A	G	14: 49,272,258 (GRCm39)		probably benign	Het
Fyb1	C	T	15: 6,610,176 (GRCm39)	P250S	probably benign	Het
Gaa	A	G	11: 119,165,739 (GRCm39)	Y84C	probably damaging	Het
Galns	A	T	8: 123,325,365 (GRCm39)	S262R	probably damaging	Het
Gfus	A	G	15: 75,798,034 (GRCm39)	S233P	probably damaging	Het
Kctd16	T	C	18: 40,663,906 (GRCm39)	I345T	probably benign	Het
Lats2	A	G	14: 57,934,717 (GRCm39)	V671A	probably damaging	Het
Maml3	C	A	3: 51,598,208 (GRCm39)	L179F	probably damaging	Het
Myo1f	T	C	17: 33,826,318 (GRCm39)	L1089P	probably damaging	Het
Nadsyn1	A	T	7: 143,357,743 (GRCm39)		probably benign	Het
Or1e34	A	G	11: 73,778,949 (GRCm39)	M83T	possibly damaging	Het
Or51k1	G	A	7: 103,661,037 (GRCm39)	P291S	probably damaging	Het
Or7d9	T	C	9: 20,197,691 (GRCm39)	V240A	probably benign	Het
Or9i1	A	G	19: 13,839,378 (GRCm39)	T74A	probably benign	Het
Otog	T	C	7: 45,926,165 (GRCm39)		probably benign	Het
Pcbd1	A	G	10: 60,927,983 (GRCm39)		probably benign	Het
Pced1a	A	G	2: 130,264,248 (GRCm39)	V164A	possibly damaging	Het
Pgd	A	G	4: 149,241,210 (GRCm39)	I233T	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Sec24d	A	T	3: 123,147,330 (GRCm39)	H733L	probably damaging	Het
Slc1a2	T	A	2: 102,574,206 (GRCm39)	N205K	probably benign	Het
Sstr2	G	T	11: 113,515,842 (GRCm39)	V254L	probably damaging	Het
Tm9sf2	G	T	14: 122,380,835 (GRCm39)	V308F	probably benign	Het
Tor3a	T	C	1: 156,501,776 (GRCm39)	K34E	probably benign	Het
Ubr4	T	A	4: 139,164,381 (GRCm39)		probably null	Het
Vmn1r56	A	G	7: 5,199,117 (GRCm39)	S167P	probably damaging	Het
Zswim3	T	A	2: 164,662,759 (GRCm39)	I413N	probably damaging	Het

Other mutations in Dtx4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01533:Dtx4	APN	19	12,455,579 (GRCm39)	missense	possibly damaging	0.88
IGL03127:Dtx4	APN	19	12,463,864 (GRCm39)	splice site	probably benign
G5030:Dtx4	UTSW	19	12,446,943 (GRCm39)	missense	probably benign	0.07
R0143:Dtx4	UTSW	19	12,463,846 (GRCm39)	missense	probably damaging	0.98
R0932:Dtx4	UTSW	19	12,469,515 (GRCm39)	missense	probably benign
R1066:Dtx4	UTSW	19	12,478,373 (GRCm39)	missense	probably damaging	0.98
R2155:Dtx4	UTSW	19	12,462,646 (GRCm39)	nonsense	probably null
R2182:Dtx4	UTSW	19	12,460,471 (GRCm39)	missense	probably null	0.75
R2362:Dtx4	UTSW	19	12,469,899 (GRCm39)	missense	probably damaging	1.00
R3880:Dtx4	UTSW	19	12,463,820 (GRCm39)	missense	probably benign	0.01
R4108:Dtx4	UTSW	19	12,478,487 (GRCm39)	missense	probably damaging	0.96
R4361:Dtx4	UTSW	19	12,462,660 (GRCm39)	missense	probably benign	0.04
R4943:Dtx4	UTSW	19	12,478,424 (GRCm39)	missense	probably damaging	1.00
R5361:Dtx4	UTSW	19	12,462,626 (GRCm39)	critical splice donor site	probably null
R5440:Dtx4	UTSW	19	12,469,681 (GRCm39)	missense	probably damaging	1.00
R5613:Dtx4	UTSW	19	12,462,767 (GRCm39)	missense	probably damaging	0.97
R5614:Dtx4	UTSW	19	12,459,547 (GRCm39)	missense	probably damaging	1.00
R5703:Dtx4	UTSW	19	12,459,574 (GRCm39)	missense	possibly damaging	0.84
R5994:Dtx4	UTSW	19	12,478,517 (GRCm39)	missense	probably damaging	1.00
R6695:Dtx4	UTSW	19	12,450,599 (GRCm39)	nonsense	probably null
R7107:Dtx4	UTSW	19	12,450,624 (GRCm39)	nonsense	probably null
R7208:Dtx4	UTSW	19	12,459,437 (GRCm39)	critical splice donor site	probably null
R7231:Dtx4	UTSW	19	12,447,022 (GRCm39)	nonsense	probably null
R7521:Dtx4	UTSW	19	12,469,861 (GRCm39)	missense	probably benign	0.30
R7609:Dtx4	UTSW	19	12,469,645 (GRCm39)	missense	probably damaging	1.00
R7721:Dtx4	UTSW	19	12,459,500 (GRCm39)	missense	probably benign	0.09
R7775:Dtx4	UTSW	19	12,469,374 (GRCm39)	missense	probably benign	0.02
R8685:Dtx4	UTSW	19	12,446,995 (GRCm39)	missense	probably benign	0.36
Z1176:Dtx4	UTSW	19	12,469,273 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16