Incidental Mutation 'IGL02173:Kctd16'
ID 282998
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kctd16
Ensembl Gene ENSMUSG00000051401
Gene Name potassium channel tetramerisation domain containing 16
Synonyms LOC383347, 2900055J20Rik, 4930434H12Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # IGL02173
Quality Score
Status
Chromosome 18
Chromosomal Location 40390015-40664683 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40663906 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 345 (I345T)
Ref Sequence ENSEMBL: ENSMUSP00000089547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091927]
AlphaFold Q5DTY9
Predicted Effect probably benign
Transcript: ENSMUST00000091927
AA Change: I345T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000089547
Gene: ENSMUSG00000051401
AA Change: I345T

DomainStartEndE-ValueType
BTB 25 130 8.7e-7 SMART
low complexity region 288 300 N/A INTRINSIC
low complexity region 374 396 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700113H08Rik A T 10: 87,061,754 (GRCm39) H68L possibly damaging Het
4930533K18Rik A G 10: 70,708,060 (GRCm39) noncoding transcript Het
4933409G03Rik A G 2: 68,443,401 (GRCm39) T182A unknown Het
Abca2 T A 2: 25,331,909 (GRCm39) D1340E probably benign Het
Abcc12 G A 8: 87,293,071 (GRCm39) A39V probably damaging Het
Acap2 T C 16: 30,926,965 (GRCm39) R510G possibly damaging Het
Ace G T 11: 105,879,817 (GRCm39) R719L probably benign Het
Adarb1 A C 10: 77,157,659 (GRCm39) F263V probably damaging Het
Ahcyl T C 16: 45,974,441 (GRCm39) N312S probably benign Het
Ambra1 T C 2: 91,748,013 (GRCm39) S1130P probably benign Het
Aqp7 A T 4: 41,034,379 (GRCm39) L260* probably null Het
Cntn5 G T 9: 9,748,401 (GRCm39) S493R probably damaging Het
Crhr2 A G 6: 55,080,165 (GRCm39) F138S probably damaging Het
D2hgdh T A 1: 93,757,611 (GRCm39) D175E probably benign Het
Dtx4 G T 19: 12,450,621 (GRCm39) Y530* probably null Het
Elp4 T A 2: 105,533,088 (GRCm39) H419L probably damaging Het
Etv6 A G 6: 134,225,690 (GRCm39) D218G possibly damaging Het
Exoc5 A G 14: 49,272,258 (GRCm39) probably benign Het
Fyb1 C T 15: 6,610,176 (GRCm39) P250S probably benign Het
Gaa A G 11: 119,165,739 (GRCm39) Y84C probably damaging Het
Galns A T 8: 123,325,365 (GRCm39) S262R probably damaging Het
Gfus A G 15: 75,798,034 (GRCm39) S233P probably damaging Het
Lats2 A G 14: 57,934,717 (GRCm39) V671A probably damaging Het
Maml3 C A 3: 51,598,208 (GRCm39) L179F probably damaging Het
Myo1f T C 17: 33,826,318 (GRCm39) L1089P probably damaging Het
Nadsyn1 A T 7: 143,357,743 (GRCm39) probably benign Het
Or1e34 A G 11: 73,778,949 (GRCm39) M83T possibly damaging Het
Or51k1 G A 7: 103,661,037 (GRCm39) P291S probably damaging Het
Or7d9 T C 9: 20,197,691 (GRCm39) V240A probably benign Het
Or9i1 A G 19: 13,839,378 (GRCm39) T74A probably benign Het
Otog T C 7: 45,926,165 (GRCm39) probably benign Het
Pcbd1 A G 10: 60,927,983 (GRCm39) probably benign Het
Pced1a A G 2: 130,264,248 (GRCm39) V164A possibly damaging Het
Pgd A G 4: 149,241,210 (GRCm39) I233T probably damaging Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Sec24d A T 3: 123,147,330 (GRCm39) H733L probably damaging Het
Slc1a2 T A 2: 102,574,206 (GRCm39) N205K probably benign Het
Sstr2 G T 11: 113,515,842 (GRCm39) V254L probably damaging Het
Tm9sf2 G T 14: 122,380,835 (GRCm39) V308F probably benign Het
Tor3a T C 1: 156,501,776 (GRCm39) K34E probably benign Het
Ubr4 T A 4: 139,164,381 (GRCm39) probably null Het
Vmn1r56 A G 7: 5,199,117 (GRCm39) S167P probably damaging Het
Zswim3 T A 2: 164,662,759 (GRCm39) I413N probably damaging Het
Other mutations in Kctd16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00501:Kctd16 APN 18 40,390,440 (GRCm39) unclassified probably benign
IGL00954:Kctd16 APN 18 40,391,853 (GRCm39) missense probably benign 0.01
IGL01844:Kctd16 APN 18 40,390,373 (GRCm39) missense probably damaging 0.99
IGL02001:Kctd16 APN 18 40,391,733 (GRCm39) missense possibly damaging 0.48
IGL02890:Kctd16 APN 18 40,390,080 (GRCm39) unclassified probably benign
IGL03112:Kctd16 APN 18 40,391,853 (GRCm39) missense probably benign 0.08
R0109:Kctd16 UTSW 18 40,392,204 (GRCm39) missense probably benign 0.06
R0109:Kctd16 UTSW 18 40,392,204 (GRCm39) missense probably benign 0.06
R0267:Kctd16 UTSW 18 40,663,930 (GRCm39) missense probably benign 0.02
R0554:Kctd16 UTSW 18 40,391,492 (GRCm39) missense probably benign
R0732:Kctd16 UTSW 18 40,391,616 (GRCm39) missense probably damaging 1.00
R0883:Kctd16 UTSW 18 40,663,828 (GRCm39) missense probably damaging 0.98
R2140:Kctd16 UTSW 18 40,392,231 (GRCm39) missense possibly damaging 0.89
R2141:Kctd16 UTSW 18 40,392,231 (GRCm39) missense possibly damaging 0.89
R2142:Kctd16 UTSW 18 40,392,231 (GRCm39) missense possibly damaging 0.89
R2160:Kctd16 UTSW 18 40,392,138 (GRCm39) missense probably damaging 1.00
R3723:Kctd16 UTSW 18 40,391,912 (GRCm39) missense possibly damaging 0.79
R3724:Kctd16 UTSW 18 40,391,912 (GRCm39) missense possibly damaging 0.79
R4712:Kctd16 UTSW 18 40,390,233 (GRCm39) unclassified probably benign
R5483:Kctd16 UTSW 18 40,663,929 (GRCm39) missense probably benign
R5538:Kctd16 UTSW 18 40,390,319 (GRCm39) nonsense probably null
R5589:Kctd16 UTSW 18 40,392,061 (GRCm39) missense probably damaging 1.00
R5767:Kctd16 UTSW 18 40,391,922 (GRCm39) missense probably benign 0.13
R5811:Kctd16 UTSW 18 40,391,505 (GRCm39) missense probably damaging 1.00
R5875:Kctd16 UTSW 18 40,390,447 (GRCm39) unclassified probably benign
R5911:Kctd16 UTSW 18 40,663,905 (GRCm39) missense probably benign 0.11
R5930:Kctd16 UTSW 18 40,663,882 (GRCm39) missense probably benign 0.10
R6017:Kctd16 UTSW 18 40,391,996 (GRCm39) missense probably damaging 1.00
R6603:Kctd16 UTSW 18 40,391,544 (GRCm39) missense probably benign
R6984:Kctd16 UTSW 18 40,390,101 (GRCm39) unclassified probably benign
R7404:Kctd16 UTSW 18 40,391,826 (GRCm39) missense probably damaging 1.00
R7597:Kctd16 UTSW 18 40,663,848 (GRCm39) missense possibly damaging 0.70
R9079:Kctd16 UTSW 18 40,390,080 (GRCm39) unclassified probably benign
R9133:Kctd16 UTSW 18 40,392,069 (GRCm39) missense probably damaging 1.00
R9283:Kctd16 UTSW 18 40,392,233 (GRCm39) missense possibly damaging 0.54
Posted On 2015-04-16