Incidental Mutation 'IGL02175:Zfp879'
| ID |
283078 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp879
|
| Ensembl Gene |
ENSMUSG00000044296 |
| Gene Name |
zinc finger protein 879 |
| Synonyms |
9630041N07Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02175
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
11 |
| Chromosomal Location |
50722858-50732379 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 50728743 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 84
(Y84N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104762
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049625]
[ENSMUST00000109133]
[ENSMUST00000109134]
|
| AlphaFold |
Q8BI99 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049625
AA Change: Y84N
PolyPhen 2
Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000061782
Gene: ENSMUSG00000044296
AA Change: Y84N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
1.54e-33 |
SMART |
|
ZnF_C2H2
|
204 |
226 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
232 |
254 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
260 |
282 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
288 |
310 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
316 |
338 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
344 |
366 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
372 |
394 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
400 |
422 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
428 |
450 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
456 |
478 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
484 |
506 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
512 |
534 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
540 |
562 |
5.21e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109133
AA Change: Y11N
PolyPhen 2
Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000104761
Gene: ENSMUSG00000044296
AA Change: Y11N
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
131 |
153 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
467 |
489 |
5.21e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109134
AA Change: Y84N
PolyPhen 2
Score 0.125 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000104762
Gene: ENSMUSG00000044296
AA Change: Y84N
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
74 |
1.54e-33 |
SMART |
|
ZnF_C2H2
|
204 |
226 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
232 |
254 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
260 |
282 |
1.16e-1 |
SMART |
|
ZnF_C2H2
|
288 |
310 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
316 |
338 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
344 |
366 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
372 |
394 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
400 |
422 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
428 |
450 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
456 |
478 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
484 |
506 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
512 |
534 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
540 |
562 |
5.21e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc12 |
A |
T |
8: 87,261,642 (GRCm39) |
|
probably null |
Het |
| Adgrf5 |
A |
G |
17: 43,761,901 (GRCm39) |
I1199V |
probably damaging |
Het |
| Atm |
T |
A |
9: 53,391,965 (GRCm39) |
H1808L |
probably damaging |
Het |
| Cadps |
C |
T |
14: 12,467,092 (GRCm38) |
V942M |
probably damaging |
Het |
| Capns1 |
T |
C |
7: 29,889,957 (GRCm39) |
D116G |
probably benign |
Het |
| Ccdc110 |
T |
G |
8: 46,393,660 (GRCm39) |
M124R |
probably benign |
Het |
| Cdh23 |
T |
C |
10: 60,167,087 (GRCm39) |
N1855S |
possibly damaging |
Het |
| Dstyk |
T |
A |
1: 132,377,129 (GRCm39) |
L245* |
probably null |
Het |
| Dync2h1 |
A |
G |
9: 7,111,548 (GRCm39) |
Y289H |
possibly damaging |
Het |
| Efcab6 |
G |
A |
15: 83,780,301 (GRCm39) |
A1044V |
probably damaging |
Het |
| Egr1 |
T |
C |
18: 34,996,108 (GRCm39) |
S297P |
probably benign |
Het |
| Ercc6l2 |
T |
C |
13: 64,017,004 (GRCm39) |
|
probably benign |
Het |
| Frem2 |
C |
T |
3: 53,563,020 (GRCm39) |
A496T |
possibly damaging |
Het |
| Hook2 |
T |
A |
8: 85,718,031 (GRCm39) |
W53R |
probably damaging |
Het |
| Med19 |
T |
A |
2: 84,509,007 (GRCm39) |
|
probably null |
Het |
| Mgrn1 |
A |
G |
16: 4,738,232 (GRCm39) |
N262S |
probably benign |
Het |
| Nbas |
T |
G |
12: 13,616,260 (GRCm39) |
|
probably null |
Het |
| Ndc80 |
A |
C |
17: 71,818,414 (GRCm39) |
M314R |
probably benign |
Het |
| Nelfcd |
A |
T |
2: 174,262,175 (GRCm39) |
T89S |
probably benign |
Het |
| Nlrp4a |
A |
T |
7: 26,174,522 (GRCm39) |
E969D |
probably damaging |
Het |
| Ntrk3 |
A |
G |
7: 77,896,976 (GRCm39) |
V687A |
probably damaging |
Het |
| Oc90 |
A |
C |
15: 65,755,674 (GRCm39) |
S224R |
possibly damaging |
Het |
| Or4a69 |
T |
C |
2: 89,312,626 (GRCm39) |
I284M |
possibly damaging |
Het |
| Plxnb1 |
C |
T |
9: 108,929,914 (GRCm39) |
H257Y |
possibly damaging |
Het |
| Prpf3 |
A |
G |
3: 95,741,419 (GRCm39) |
V579A |
probably damaging |
Het |
| Rarres1 |
T |
C |
3: 67,403,089 (GRCm39) |
N104S |
probably benign |
Het |
| Serpina1d |
T |
C |
12: 103,731,955 (GRCm39) |
|
probably null |
Het |
| Sik2 |
G |
A |
9: 50,806,909 (GRCm39) |
Q834* |
probably null |
Het |
| Slc39a10 |
G |
A |
1: 46,857,288 (GRCm39) |
A696V |
probably damaging |
Het |
| Snx13 |
T |
A |
12: 35,182,061 (GRCm39) |
N703K |
possibly damaging |
Het |
| Spaca9 |
T |
C |
2: 28,585,936 (GRCm39) |
I43V |
probably benign |
Het |
| Tor1aip2 |
T |
C |
1: 155,940,752 (GRCm39) |
S353P |
probably damaging |
Het |
| Trmt1l |
T |
C |
1: 151,324,235 (GRCm39) |
S361P |
probably benign |
Het |
| Trpm2 |
T |
C |
10: 77,773,741 (GRCm39) |
H558R |
probably benign |
Het |
| Vmn1r75 |
T |
C |
7: 11,614,774 (GRCm39) |
C127R |
probably damaging |
Het |
|
| Other mutations in Zfp879 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01659:Zfp879
|
APN |
11 |
50,729,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02259:Zfp879
|
APN |
11 |
50,729,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
Bazooka
|
UTSW |
11 |
50,729,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
joe
|
UTSW |
11 |
50,724,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0131:Zfp879
|
UTSW |
11 |
50,724,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Zfp879
|
UTSW |
11 |
50,724,784 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1576:Zfp879
|
UTSW |
11 |
50,724,376 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1616:Zfp879
|
UTSW |
11 |
50,723,473 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1701:Zfp879
|
UTSW |
11 |
50,724,060 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1965:Zfp879
|
UTSW |
11 |
50,724,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2057:Zfp879
|
UTSW |
11 |
50,723,428 (GRCm39) |
missense |
probably benign |
|
|
R2058:Zfp879
|
UTSW |
11 |
50,723,428 (GRCm39) |
missense |
probably benign |
|
|
R2219:Zfp879
|
UTSW |
11 |
50,724,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Zfp879
|
UTSW |
11 |
50,723,989 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3112:Zfp879
|
UTSW |
11 |
50,723,989 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4658:Zfp879
|
UTSW |
11 |
50,724,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Zfp879
|
UTSW |
11 |
50,724,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4998:Zfp879
|
UTSW |
11 |
50,728,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6362:Zfp879
|
UTSW |
11 |
50,729,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6930:Zfp879
|
UTSW |
11 |
50,723,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7091:Zfp879
|
UTSW |
11 |
50,724,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7186:Zfp879
|
UTSW |
11 |
50,724,621 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7218:Zfp879
|
UTSW |
11 |
50,723,508 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8138:Zfp879
|
UTSW |
11 |
50,724,275 (GRCm39) |
nonsense |
probably null |
|
|
R8445:Zfp879
|
UTSW |
11 |
50,724,213 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8523:Zfp879
|
UTSW |
11 |
50,728,757 (GRCm39) |
missense |
probably benign |
|
|
R8725:Zfp879
|
UTSW |
11 |
50,729,321 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8790:Zfp879
|
UTSW |
11 |
50,723,429 (GRCm39) |
nonsense |
probably null |
|
|
R8882:Zfp879
|
UTSW |
11 |
50,724,763 (GRCm39) |
nonsense |
probably null |
|
|
R9229:Zfp879
|
UTSW |
11 |
50,723,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0066:Zfp879
|
UTSW |
11 |
50,723,914 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1177:Zfp879
|
UTSW |
11 |
50,724,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation