Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02177:Gpr33'

283163

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr33

Ensembl Gene

ENSMUSG00000035148

Gene Name

G protein-coupled receptor 33

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02177

Quality Score

Status

Chromosome

Chromosomal Location

52069786-52074846 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 52070863 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 59 (Q59K)

Ref Sequence

ENSEMBL: ENSMUSP00000048059 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040161]

AlphaFold

O88416

Predicted Effect

probably benign
Transcript: ENSMUST00000040161
AA Change: Q59K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000048059
Gene: ENSMUSG00000035148
AA Change: Q59K

Domain	Start	End	E-Value	Type
Pfam:7tm_1	46	299	3.6e-32	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene has been identified as an orphan chemoattractant G-protein-coupled receptors (GPCR) pseudogene. Studies have shown that the inactivated gene is present as the predominant allele in the human population. A small fraction of the human population has been found to harbor an intact allele.[provided by RefSeq, Oct 2010]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Add3	T	G	19: 53,205,323 (GRCm39)	Y24*	probably null	Het
Catsperb	A	G	12: 101,507,721 (GRCm39)	Y496C	probably damaging	Het
Ccdc183	C	T	2: 25,502,095 (GRCm39)	E260K	probably benign	Het
Ccdc81	A	C	7: 89,524,988 (GRCm39)	M531R	possibly damaging	Het
Cyp3a16	T	A	5: 145,386,964 (GRCm39)	N342I	probably benign	Het
Defb43	T	C	14: 63,249,266 (GRCm39)	V3A	probably benign	Het
Dpyd	T	A	3: 118,858,559 (GRCm39)	I591N	possibly damaging	Het
Dpysl5	T	G	5: 30,902,622 (GRCm39)	V18G	probably damaging	Het
Erc2	A	T	14: 27,620,580 (GRCm39)	M69L	probably benign	Het
Fam184b	G	T	5: 45,690,157 (GRCm39)	Y817*	probably null	Het
Fyb1	G	T	15: 6,688,047 (GRCm39)		probably null	Het
Heatr3	T	G	8: 88,883,351 (GRCm39)	F278V	probably benign	Het
Hectd1	A	T	12: 51,819,103 (GRCm39)	D1292E	probably damaging	Het
Herc1	A	T	9: 66,341,793 (GRCm39)	M1861L	probably benign	Het
Hspg2	T	A	4: 137,242,627 (GRCm39)	L614Q	probably damaging	Het
Itpr3	A	G	17: 27,318,588 (GRCm39)	R915G	possibly damaging	Het
Jhy	T	C	9: 40,809,553 (GRCm39)	D646G	probably damaging	Het
Lrig1	T	A	6: 94,640,977 (GRCm39)	N76I	possibly damaging	Het
Macc1	A	G	12: 119,429,292 (GRCm39)	D814G	probably damaging	Het
Mapk8ip1	T	C	2: 92,217,092 (GRCm39)	D401G	probably damaging	Het
Nedd4	T	A	9: 72,654,439 (GRCm39)	S865T	probably damaging	Het
Or9s27	G	A	1: 92,516,479 (GRCm39)	M142I	possibly damaging	Het
Pi4ka	A	T	16: 17,136,146 (GRCm39)	D937E	probably benign	Het
Prkcd	T	A	14: 30,327,844 (GRCm39)	I81F	probably damaging	Het
Ranbp9	A	T	13: 43,573,193 (GRCm39)	C280S	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Scn1b	T	C	7: 30,816,655 (GRCm39)	*219W	probably null	Het
Slain2	T	C	5: 73,072,008 (GRCm39)	V14A	probably benign	Het
Soat1	A	T	1: 156,268,073 (GRCm39)		probably benign	Het
Tbc1d4	T	A	14: 101,692,375 (GRCm39)	M1030L	possibly damaging	Het
Tenm4	T	C	7: 96,544,869 (GRCm39)	V2295A	probably benign	Het
Tmem135	A	G	7: 88,987,661 (GRCm39)	Y46H	probably damaging	Het
Tnfsf18	A	T	1: 161,331,354 (GRCm39)	D168V	probably damaging	Het
Trdn	T	C	10: 33,015,169 (GRCm39)	V41A	probably damaging	Het
Trpc5	G	T	X: 143,264,234 (GRCm39)	L208I	probably damaging	Het
Vmn1r50	T	C	6: 90,085,139 (GRCm39)	Y295H	probably benign	Het
Vmn2r18	T	G	5: 151,510,274 (GRCm39)	H33P	possibly damaging	Het
Vmn2r84	T	C	10: 130,227,881 (GRCm39)	I118M	probably benign	Het

Other mutations in Gpr33

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01655:Gpr33	APN	12	52,070,343 (GRCm39)	missense	probably damaging	0.98
IGL03090:Gpr33	APN	12	52,070,809 (GRCm39)	missense	probably damaging	0.99
R0883:Gpr33	UTSW	12	52,070,418 (GRCm39)	missense	probably benign	0.17
R1112:Gpr33	UTSW	12	52,070,155 (GRCm39)	missense	probably damaging	1.00
R1127:Gpr33	UTSW	12	52,070,252 (GRCm39)	missense	probably damaging	1.00
R1742:Gpr33	UTSW	12	52,071,045 (GRCm39)	critical splice acceptor site	probably null
R1967:Gpr33	UTSW	12	52,070,991 (GRCm39)	missense	probably benign
R2208:Gpr33	UTSW	12	52,070,236 (GRCm39)	missense	probably benign	0.00
R2917:Gpr33	UTSW	12	52,070,379 (GRCm39)	missense	possibly damaging	0.63
R4308:Gpr33	UTSW	12	52,070,423 (GRCm39)	nonsense	probably null
R4725:Gpr33	UTSW	12	52,070,892 (GRCm39)	missense	probably damaging	1.00
R5616:Gpr33	UTSW	12	52,070,377 (GRCm39)	missense	probably damaging	0.99
R7055:Gpr33	UTSW	12	52,071,036 (GRCm39)	start codon destroyed	probably null	0.99
R7272:Gpr33	UTSW	12	52,070,848 (GRCm39)	missense	probably damaging	0.99
R7419:Gpr33	UTSW	12	52,070,050 (GRCm39)	missense	probably benign	0.00
R8313:Gpr33	UTSW	12	52,070,907 (GRCm39)	missense	probably benign	0.00
R8514:Gpr33	UTSW	12	52,070,181 (GRCm39)	missense	probably benign	0.06

Posted On

2015-04-16