Incidental Mutation 'IGL00913:Or7a35'
ID 28318
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7a35
Ensembl Gene ENSMUSG00000063216
Gene Name olfactory receptor family 7 subfamily A member 35
Synonyms Olfr1351, GA_x6K02T2QGN0-2794907-2793948, MOR139-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # IGL00913
Quality Score
Status
Chromosome 10
Chromosomal Location 78853158-78854117 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 78854085 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 310 (T310A)
Ref Sequence ENSEMBL: ENSMUSP00000149241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000203906] [ENSMUST00000216030]
AlphaFold Q8VGU6
Predicted Effect probably benign
Transcript: ENSMUST00000080730
AA Change: T310A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: T310A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203906
AA Change: T310A
SMART Domains Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: T310A

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216030
AA Change: T310A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 A G 17: 42,977,793 (GRCm39) S517P possibly damaging Het
Arl4c T C 1: 88,629,106 (GRCm39) D94G probably damaging Het
Bag5 T C 12: 111,677,766 (GRCm39) E19G probably damaging Het
Carf T A 1: 60,187,114 (GRCm39) D537E probably benign Het
Cd177 C A 7: 24,455,620 (GRCm39) D301Y probably damaging Het
Csmd1 C T 8: 16,121,301 (GRCm39) V1799I probably benign Het
Cyp4x1 T A 4: 114,970,060 (GRCm39) I356F probably benign Het
F5 A T 1: 164,032,465 (GRCm39) H1804L probably damaging Het
Fras1 G T 5: 96,842,935 (GRCm39) G1718C probably damaging Het
Ganc T C 2: 120,269,933 (GRCm39) probably benign Het
Hs3st5 A G 10: 36,708,846 (GRCm39) D127G probably damaging Het
Inpp5a A G 7: 139,096,637 (GRCm39) D154G probably benign Het
Kif16b T A 2: 142,545,927 (GRCm39) R1134* probably null Het
Lrrc66 C T 5: 73,765,499 (GRCm39) A515T possibly damaging Het
Map3k10 C T 7: 27,362,640 (GRCm39) probably benign Het
Mideas T A 12: 84,219,632 (GRCm39) I441L probably benign Het
Mrpl12 G A 11: 120,376,202 (GRCm39) D71N possibly damaging Het
Nfix A T 8: 85,453,106 (GRCm39) V316E probably damaging Het
Nop2 A G 6: 125,116,784 (GRCm39) Y346C probably damaging Het
Nrbp1 A G 5: 31,408,403 (GRCm39) E513G possibly damaging Het
Ogfrl1 T C 1: 23,409,171 (GRCm39) I352V probably benign Het
Or8b48 T A 9: 38,492,672 (GRCm39) V33E probably damaging Het
Oxr1 G A 15: 41,683,539 (GRCm39) V15I possibly damaging Het
Pik3r6 T G 11: 68,442,147 (GRCm39) F697C probably damaging Het
Ptk2 A G 15: 73,167,238 (GRCm39) probably benign Het
Rnft2 G A 5: 118,339,280 (GRCm39) T380M probably damaging Het
Scel A G 14: 103,819,245 (GRCm39) N346S probably benign Het
Sema4a T A 3: 88,357,117 (GRCm39) T153S probably damaging Het
Serinc2 A T 4: 130,158,201 (GRCm39) L82Q possibly damaging Het
Sin3a A G 9: 57,005,402 (GRCm39) T392A probably benign Het
Slc25a38 T A 9: 119,949,373 (GRCm39) Y108* probably null Het
Tmc8 G A 11: 117,677,330 (GRCm39) G317R probably damaging Het
Trpc3 A G 3: 36,694,788 (GRCm39) V722A possibly damaging Het
Unc93a2 A T 17: 7,637,138 (GRCm39) V130D probably damaging Het
Other mutations in Or7a35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01833:Or7a35 APN 10 78,853,770 (GRCm39) missense probably benign
IGL02141:Or7a35 APN 10 78,853,555 (GRCm39) missense probably damaging 1.00
IGL02178:Or7a35 APN 10 78,853,554 (GRCm39) missense possibly damaging 0.59
R1070:Or7a35 UTSW 10 78,853,684 (GRCm39) missense probably damaging 0.99
R1631:Or7a35 UTSW 10 78,853,239 (GRCm39) missense probably benign 0.00
R1646:Or7a35 UTSW 10 78,853,340 (GRCm39) nonsense probably null
R1781:Or7a35 UTSW 10 78,853,159 (GRCm39) start codon destroyed probably null 0.89
R2358:Or7a35 UTSW 10 78,854,022 (GRCm39) missense probably damaging 1.00
R3161:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R3162:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R3162:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R5874:Or7a35 UTSW 10 78,853,191 (GRCm39) missense possibly damaging 0.95
R6382:Or7a35 UTSW 10 78,853,351 (GRCm39) missense probably damaging 1.00
R7108:Or7a35 UTSW 10 78,853,483 (GRCm39) nonsense probably null
R7567:Or7a35 UTSW 10 78,853,379 (GRCm39) missense probably benign 0.04
R7568:Or7a35 UTSW 10 78,853,341 (GRCm39) missense probably benign
R7915:Or7a35 UTSW 10 78,853,264 (GRCm39) missense probably damaging 1.00
R7936:Or7a35 UTSW 10 78,853,872 (GRCm39) missense probably damaging 1.00
R9687:Or7a35 UTSW 10 78,853,843 (GRCm39) missense probably damaging 1.00
Z1176:Or7a35 UTSW 10 78,854,039 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17