Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02178:Crispld1'

283225

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Crispld1

Ensembl Gene

ENSMUSG00000025776

Gene Name

cysteine-rich secretory protein LCCL domain containing 1

Synonyms

Cocoacrisp

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.125) question?

Stock #

IGL02178

Quality Score

Status

Chromosome

Chromosomal Location

17797269-17836568 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 17832327 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124095 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095075] [ENSMUST00000159958]

AlphaFold

Q8CGD2

Predicted Effect

probably benign
Transcript: ENSMUST00000095075

SMART Domains

Protein: ENSMUSP00000092686
Gene: ENSMUSG00000025776

Domain	Start	End	E-Value	Type
SCP	60	214	1.63e-41	SMART
LCCL	291	375	1.6e-52	SMART
LCCL	392	483	1.55e-59	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000159958

SMART Domains

Protein: ENSMUSP00000124095
Gene: ENSMUSG00000025776

Domain	Start	End	E-Value	Type
SCP	60	214	1.63e-41	SMART
LCCL	291	375	1.6e-52	SMART
LCCL	392	483	1.55e-59	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189853

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	A	14: 32,384,418 (GRCm39)	T516S	possibly damaging	Het
6820408C15Rik	T	C	2: 152,269,921 (GRCm39)		probably benign	Het
Ak5	T	C	3: 152,232,422 (GRCm39)	D331G	probably benign	Het
Ar	A	G	X: 97,349,044 (GRCm39)	D675G	probably damaging	Het
Arhgap23	A	G	11: 97,343,179 (GRCm39)	D276G	probably benign	Het
Arhgef3	C	T	14: 26,987,486 (GRCm39)	R40*	probably null	Het
Atp1b4	G	T	X: 37,421,695 (GRCm39)	R293L	possibly damaging	Het
Borcs8	T	C	8: 70,617,897 (GRCm39)	L85P	probably damaging	Het
Carmil1	T	G	13: 24,278,386 (GRCm39)	K194N	probably damaging	Het
Catsper4	T	A	4: 133,954,637 (GRCm39)	K4N	probably benign	Het
Ccdc30	T	C	4: 119,206,921 (GRCm39)		probably benign	Het
Cd101	A	G	3: 100,901,082 (GRCm39)	S997P	probably damaging	Het
Cdkl5	G	A	X: 159,599,889 (GRCm39)	T792I	probably benign	Het
Cep135	A	G	5: 76,743,321 (GRCm39)	Y185C	probably damaging	Het
Clcn5	A	G	X: 7,052,563 (GRCm39)	Y59H	possibly damaging	Het
Col6a1	A	T	10: 76,546,909 (GRCm39)	I771N	unknown	Het
Fbxl13	A	G	5: 21,825,718 (GRCm39)	I128T	possibly damaging	Het
Gga1	T	A	15: 78,776,247 (GRCm39)	M430K	probably benign	Het
Has2	A	G	15: 56,545,456 (GRCm39)	Y49H	probably damaging	Het
Ivd	A	G	2: 118,701,915 (GRCm39)	I116V	probably benign	Het
Krt75	T	C	15: 101,481,226 (GRCm39)	N183D	probably benign	Het
Map3k9	A	T	12: 81,790,611 (GRCm39)	I314N	probably damaging	Het
Map6d1	T	G	16: 20,055,448 (GRCm39)	E129D	probably damaging	Het
Mettl22	T	C	16: 8,296,146 (GRCm39)	V145A	probably benign	Het
Muc5ac	T	A	7: 141,359,184 (GRCm39)		probably benign	Het
Mycbp2	A	G	14: 103,461,802 (GRCm39)	F1416L	probably benign	Het
Nlrc4	T	C	17: 74,753,838 (GRCm39)	I182V	probably damaging	Het
Or5b21	T	A	19: 12,839,907 (GRCm39)	I256N	possibly damaging	Het
Or7a35	T	C	10: 78,853,554 (GRCm39)	Y133H	possibly damaging	Het
Phc3	T	C	3: 30,984,012 (GRCm39)	T668A	possibly damaging	Het
Pheta2	T	A	15: 82,227,527 (GRCm39)	D15E	possibly damaging	Het
Ppp2r2a	T	C	14: 67,260,546 (GRCm39)	Y244C	probably damaging	Het
Prkcq	A	C	2: 11,281,851 (GRCm39)	Y460S	possibly damaging	Het
Prmt8	T	A	6: 127,674,770 (GRCm39)	E286V	probably benign	Het
Ptprb	A	T	10: 116,158,437 (GRCm39)	M503L	probably benign	Het
Ptprq	A	T	10: 107,522,180 (GRCm39)	D590E	probably benign	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rps6kc1	A	T	1: 190,604,033 (GRCm39)	S196R	possibly damaging	Het
Ryr3	A	G	2: 112,656,144 (GRCm39)	Y1951H	probably benign	Het
Sbno1	A	T	5: 124,538,258 (GRCm39)		probably null	Het
Sde2	T	G	1: 180,678,796 (GRCm39)	L20R	possibly damaging	Het
Slco1a5	A	T	6: 142,208,414 (GRCm39)	C81*	probably null	Het
Snx2	A	G	18: 53,332,857 (GRCm39)	E177G	possibly damaging	Het
Spg11	A	T	2: 121,927,783 (GRCm39)	V667D	probably damaging	Het
Tas2r115	T	C	6: 132,714,271 (GRCm39)	T227A	probably benign	Het
Tmed9	A	G	13: 55,741,108 (GRCm39)	H41R	possibly damaging	Het
Vmn1r35	T	G	6: 66,656,086 (GRCm39)	S28R	probably damaging	Het
Vmn2r110	A	C	17: 20,804,706 (GRCm39)		probably null	Het
Vstm2l	T	C	2: 157,777,337 (GRCm39)	Y72H	probably damaging	Het
Wdr38	A	T	2: 38,888,424 (GRCm39)	N7I	probably damaging	Het
Zbtb4	A	T	11: 69,667,255 (GRCm39)	R187*	probably null	Het
Zfp598	A	G	17: 24,896,517 (GRCm39)	D198G	probably damaging	Het
Zp2	G	T	7: 119,732,973 (GRCm39)	A629E	possibly damaging	Het

Other mutations in Crispld1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01432:Crispld1	APN	1	17,817,025 (GRCm39)	missense	probably benign	0.21
IGL01610:Crispld1	APN	1	17,816,949 (GRCm39)	splice site	probably null
IGL01991:Crispld1	APN	1	17,823,241 (GRCm39)	missense	probably benign
IGL02004:Crispld1	APN	1	17,817,744 (GRCm39)	missense	probably damaging	1.00
IGL02200:Crispld1	APN	1	17,820,557 (GRCm39)	unclassified	probably benign
IGL02251:Crispld1	APN	1	17,799,064 (GRCm39)	missense	probably benign	0.06
IGL02506:Crispld1	APN	1	17,826,529 (GRCm39)	missense	probably damaging	0.99
IGL02883:Crispld1	APN	1	17,817,013 (GRCm39)	missense	possibly damaging	0.87
IGL03310:Crispld1	APN	1	17,815,701 (GRCm39)	splice site	probably benign
milliliter	UTSW	1	17,821,025 (GRCm39)	missense	possibly damaging	0.81
Spoonful	UTSW	1	17,832,365 (GRCm39)	missense	probably damaging	1.00
R0068:Crispld1	UTSW	1	17,823,212 (GRCm39)	missense	possibly damaging	0.89
R0324:Crispld1	UTSW	1	17,819,815 (GRCm39)	missense	probably benign
R0542:Crispld1	UTSW	1	17,816,992 (GRCm39)	missense	possibly damaging	0.75
R1117:Crispld1	UTSW	1	17,819,846 (GRCm39)	missense	probably benign	0.03
R1157:Crispld1	UTSW	1	17,815,587 (GRCm39)	missense	possibly damaging	0.70
R1585:Crispld1	UTSW	1	17,821,024 (GRCm39)	missense	possibly damaging	0.68
R1630:Crispld1	UTSW	1	17,799,022 (GRCm39)	missense	probably benign
R2081:Crispld1	UTSW	1	17,832,403 (GRCm39)	missense	probably damaging	0.99
R2143:Crispld1	UTSW	1	17,819,860 (GRCm39)	missense	probably benign
R2472:Crispld1	UTSW	1	17,816,052 (GRCm39)	missense	probably null	0.12
R2520:Crispld1	UTSW	1	17,821,000 (GRCm39)	missense	probably damaging	1.00
R4476:Crispld1	UTSW	1	17,817,734 (GRCm39)	missense	probably damaging	1.00
R4486:Crispld1	UTSW	1	17,823,102 (GRCm39)	missense	probably benign	0.01
R4779:Crispld1	UTSW	1	17,819,831 (GRCm39)	missense	probably benign
R5508:Crispld1	UTSW	1	17,823,207 (GRCm39)	missense	probably damaging	1.00
R5568:Crispld1	UTSW	1	17,820,495 (GRCm39)	missense	probably benign	0.01
R6155:Crispld1	UTSW	1	17,823,241 (GRCm39)	missense	probably benign
R6252:Crispld1	UTSW	1	17,819,731 (GRCm39)	missense	probably benign	0.00
R6361:Crispld1	UTSW	1	17,832,455 (GRCm39)	missense	probably damaging	0.99
R6617:Crispld1	UTSW	1	17,798,886 (GRCm39)	missense	probably benign	0.02
R6760:Crispld1	UTSW	1	17,821,025 (GRCm39)	missense	possibly damaging	0.81
R6961:Crispld1	UTSW	1	17,832,365 (GRCm39)	missense	probably damaging	1.00
R7278:Crispld1	UTSW	1	17,823,102 (GRCm39)	missense	probably benign	0.01
R7403:Crispld1	UTSW	1	17,817,820 (GRCm39)	missense	probably damaging	1.00
R7592:Crispld1	UTSW	1	17,798,990 (GRCm39)	missense	possibly damaging	0.64
R7837:Crispld1	UTSW	1	17,798,954 (GRCm39)	missense	probably benign	0.42
R8906:Crispld1	UTSW	1	17,820,995 (GRCm39)	missense	possibly damaging	0.95
R9331:Crispld1	UTSW	1	17,832,454 (GRCm39)	missense	probably damaging	0.99
R9477:Crispld1	UTSW	1	17,816,956 (GRCm39)	missense	probably benign	0.44
Z1088:Crispld1	UTSW	1	17,834,300 (GRCm39)	missense	probably benign
Z1176:Crispld1	UTSW	1	17,823,075 (GRCm39)	missense	possibly damaging	0.60
Z1176:Crispld1	UTSW	1	17,798,837 (GRCm39)	start gained	probably benign
Z1177:Crispld1	UTSW	1	17,834,316 (GRCm39)	frame shift	probably null

Posted On

2015-04-16