Incidental Mutation 'IGL02179:Nol11'
ID 283229
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nol11
Ensembl Gene ENSMUSG00000018433
Gene Name nucleolar protein 11
Synonyms 1500002M01Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.933) question?
Stock # IGL02179
Quality Score
Status
Chromosome 11
Chromosomal Location 107057489-107080207 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to G at 107080082 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000102368 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018577] [ENSMUST00000106757]
AlphaFold Q8BJW5
Predicted Effect probably null
Transcript: ENSMUST00000018577
AA Change: M1T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000018577
Gene: ENSMUSG00000018433
AA Change: M1T

DomainStartEndE-ValueType
SCOP:d1jmxb_ 32 176 3e-3 SMART
Pfam:NUC205 200 243 3.7e-26 PFAM
low complexity region 619 629 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106757
AA Change: M1T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000102368
Gene: ENSMUSG00000018433
AA Change: M1T

DomainStartEndE-ValueType
SCOP:d1jmxb_ 32 176 3e-3 SMART
Pfam:NUC205 200 243 7.3e-29 PFAM
low complexity region 599 609 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119942
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136917
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139168
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 C A 2: 31,682,261 (GRCm39) A385D probably damaging Het
Ace A G 11: 105,860,615 (GRCm39) D174G probably benign Het
Aldh1l2 A G 10: 83,358,701 (GRCm39) V98A probably benign Het
AU040320 T A 4: 126,729,405 (GRCm39) F522L probably benign Het
Ccdc73 A G 2: 104,737,913 (GRCm39) D3G probably damaging Het
Cdk14 A C 5: 5,153,845 (GRCm39) L199V probably damaging Het
Cdk15 G T 1: 59,370,100 (GRCm39) A381S possibly damaging Het
Cyb5a A G 18: 84,891,280 (GRCm39) I68V probably benign Het
Dock5 G A 14: 68,043,945 (GRCm39) probably benign Het
Fbxw24 T A 9: 109,438,973 (GRCm39) K201* probably null Het
Gm5852 C T 3: 93,635,023 (GRCm39) noncoding transcript Het
Gsdma3 A G 11: 98,526,097 (GRCm39) K274E possibly damaging Het
Hoxa7 T A 6: 52,192,854 (GRCm39) Q178L probably damaging Het
Itgae G T 11: 73,024,844 (GRCm39) V992L probably benign Het
Klk1b26 A G 7: 43,665,736 (GRCm39) N183D probably benign Het
Krt39 A T 11: 99,411,667 (GRCm39) S140T probably damaging Het
Lama2 G A 10: 26,946,360 (GRCm39) T1953I probably benign Het
Mmp1a G A 9: 7,464,273 (GRCm39) R26Q probably benign Het
Myh7b A C 2: 155,456,411 (GRCm39) I175L probably benign Het
Nrxn1 T A 17: 90,937,511 (GRCm39) I641F probably damaging Het
Or51ag1 A C 7: 103,155,934 (GRCm39) L73R probably damaging Het
Or8k3 A T 2: 86,058,591 (GRCm39) C241* probably null Het
Or9i2 T C 19: 13,815,851 (GRCm39) T229A probably benign Het
Parn G T 16: 13,485,456 (GRCm39) H13Q probably benign Het
Pcnx1 T C 12: 81,980,493 (GRCm39) probably benign Het
Pdcd10 T C 3: 75,434,922 (GRCm39) D60G probably damaging Het
Phka2 G A X: 159,337,376 (GRCm39) probably null Het
Ppargc1a A T 5: 51,631,053 (GRCm39) D525E possibly damaging Het
Rad54l2 C A 9: 106,597,589 (GRCm39) R139L probably damaging Het
Rnf20 T C 4: 49,638,712 (GRCm39) V178A probably benign Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Sdccag8 C T 1: 176,705,622 (GRCm39) H479Y probably benign Het
Taf8 T C 17: 47,813,158 (GRCm39) T13A probably benign Het
Ttc8 T C 12: 98,930,796 (GRCm39) L270P possibly damaging Het
Ttn G A 2: 76,717,712 (GRCm39) Q365* probably null Het
Uchl1 A G 5: 66,833,637 (GRCm39) Q2R probably benign Het
Ufl1 A G 4: 25,254,896 (GRCm39) V440A probably damaging Het
Other mutations in Nol11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00646:Nol11 APN 11 107,064,286 (GRCm39) missense probably benign
IGL01656:Nol11 APN 11 107,079,998 (GRCm39) missense probably benign 0.00
IGL01687:Nol11 APN 11 107,077,695 (GRCm39) missense probably damaging 0.97
IGL02538:Nol11 APN 11 107,064,199 (GRCm39) missense probably benign 0.02
IGL03395:Nol11 APN 11 107,066,548 (GRCm39) missense probably benign 0.06
R0526:Nol11 UTSW 11 107,075,597 (GRCm39) nonsense probably null
R1734:Nol11 UTSW 11 107,066,449 (GRCm39) missense possibly damaging 0.80
R2143:Nol11 UTSW 11 107,071,881 (GRCm39) missense probably benign 0.03
R2385:Nol11 UTSW 11 107,080,032 (GRCm39) missense probably benign 0.40
R3036:Nol11 UTSW 11 107,064,070 (GRCm39) missense possibly damaging 0.87
R3522:Nol11 UTSW 11 107,064,454 (GRCm39) missense possibly damaging 0.94
R3895:Nol11 UTSW 11 107,059,173 (GRCm39) missense probably damaging 1.00
R4404:Nol11 UTSW 11 107,064,551 (GRCm39) missense probably damaging 1.00
R4664:Nol11 UTSW 11 107,071,826 (GRCm39) missense possibly damaging 0.89
R4705:Nol11 UTSW 11 107,075,544 (GRCm39) intron probably benign
R5704:Nol11 UTSW 11 107,064,195 (GRCm39) missense probably benign 0.43
R5991:Nol11 UTSW 11 107,061,971 (GRCm39) missense probably benign 0.02
R6221:Nol11 UTSW 11 107,062,442 (GRCm39) missense possibly damaging 0.50
R6222:Nol11 UTSW 11 107,062,442 (GRCm39) missense possibly damaging 0.50
R6223:Nol11 UTSW 11 107,062,442 (GRCm39) missense possibly damaging 0.50
R6285:Nol11 UTSW 11 107,071,860 (GRCm39) missense probably benign 0.01
R6467:Nol11 UTSW 11 107,071,912 (GRCm39) missense possibly damaging 0.95
R7080:Nol11 UTSW 11 107,070,878 (GRCm39) missense probably damaging 1.00
R7679:Nol11 UTSW 11 107,064,142 (GRCm39) missense probably benign 0.00
R7767:Nol11 UTSW 11 107,069,908 (GRCm39) missense possibly damaging 0.67
R8831:Nol11 UTSW 11 107,067,662 (GRCm39) missense probably benign
R9063:Nol11 UTSW 11 107,069,857 (GRCm39) missense possibly damaging 0.62
R9063:Nol11 UTSW 11 107,064,240 (GRCm39) missense probably benign 0.04
R9329:Nol11 UTSW 11 107,071,765 (GRCm39) missense probably damaging 1.00
R9378:Nol11 UTSW 11 107,064,505 (GRCm39) missense probably benign 0.29
R9473:Nol11 UTSW 11 107,075,581 (GRCm39) missense probably null 0.81
R9515:Nol11 UTSW 11 107,064,278 (GRCm39) missense possibly damaging 0.76
R9771:Nol11 UTSW 11 107,069,914 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16