Incidental Mutation 'IGL02078:Nadk'
ID 283369
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nadk
Ensembl Gene ENSMUSG00000029063
Gene Name NAD kinase
Synonyms 4432404C02Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.937) question?
Stock # IGL02078
Quality Score
Status
Chromosome 4
Chromosomal Location 155646838-155675458 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to C at 155663860 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117504 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030939] [ENSMUST00000105612] [ENSMUST00000105613] [ENSMUST00000135429] [ENSMUST00000143840] [ENSMUST00000146080]
AlphaFold P58058
Predicted Effect probably benign
Transcript: ENSMUST00000030939
SMART Domains Protein: ENSMUSP00000030939
Gene: ENSMUSG00000029063

DomainStartEndE-ValueType
Pfam:NAD_kinase 106 406 2.5e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105612
SMART Domains Protein: ENSMUSP00000101237
Gene: ENSMUSG00000029063

DomainStartEndE-ValueType
Pfam:NAD_kinase 30 330 7.6e-66 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105613
SMART Domains Protein: ENSMUSP00000101238
Gene: ENSMUSG00000029063

DomainStartEndE-ValueType
Pfam:NAD_kinase 106 406 1.4e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135429
Predicted Effect probably benign
Transcript: ENSMUST00000143840
Predicted Effect probably benign
Transcript: ENSMUST00000146080
SMART Domains Protein: ENSMUSP00000117504
Gene: ENSMUSG00000029063

DomainStartEndE-ValueType
PDB:3PFN|D 68 85 8e-7 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147062
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933412E24Rik T C 15: 59,888,179 (GRCm39) D87G probably benign Het
Acap1 C T 11: 69,786,112 (GRCm39) R18Q probably damaging Het
Atp1a1 A C 3: 101,499,179 (GRCm39) V140G probably damaging Het
Bmpr1b G A 3: 141,576,498 (GRCm39) P112S possibly damaging Het
Chst8 T A 7: 34,374,759 (GRCm39) N360I possibly damaging Het
Cldn23 A T 8: 36,293,359 (GRCm39) V43E possibly damaging Het
Clta T C 4: 44,030,232 (GRCm39) F168S probably damaging Het
Cyp2c40 T C 19: 39,755,926 (GRCm39) I463V probably benign Het
E2f2 A G 4: 135,920,323 (GRCm39) D436G probably damaging Het
Fbxo24 T G 5: 137,622,611 (GRCm39) T52P probably damaging Het
Gria4 G A 9: 4,793,878 (GRCm39) A60V probably damaging Het
Grm1 C T 10: 10,565,354 (GRCm39) V985M probably benign Het
Hexa A G 9: 59,464,586 (GRCm39) T159A probably benign Het
Inf2 T A 12: 112,568,048 (GRCm39) V200E probably damaging Het
Kif20b T A 19: 34,913,044 (GRCm39) V319E probably damaging Het
Klhl10 A G 11: 100,336,577 (GRCm39) D188G probably benign Het
Mobp G A 9: 119,996,980 (GRCm39) R37H probably damaging Het
Mybpc2 T A 7: 44,153,204 (GRCm39) D1086V probably damaging Het
Or7g33 T A 9: 19,448,749 (GRCm39) H159L probably benign Het
Per1 A G 11: 68,995,125 (GRCm39) E619G probably damaging Het
Rab3gap1 G A 1: 127,796,652 (GRCm39) probably benign Het
Rimkla A G 4: 119,325,344 (GRCm39) L355P probably damaging Het
Rnf139 A G 15: 58,771,880 (GRCm39) D635G possibly damaging Het
Sall1 T A 8: 89,757,003 (GRCm39) N1034Y probably damaging Het
Serpinb13 A T 1: 106,926,688 (GRCm39) Q228L probably damaging Het
Sin3b G T 8: 73,480,208 (GRCm39) M903I possibly damaging Het
Slco1a5 A T 6: 142,200,172 (GRCm39) M204K probably benign Het
Smo A G 6: 29,754,707 (GRCm39) D259G possibly damaging Het
Spata31g1 A C 4: 42,972,685 (GRCm39) K673Q possibly damaging Het
Sult2a4 T C 7: 13,723,469 (GRCm39) I15M probably benign Het
Ttn T A 2: 76,772,785 (GRCm39) probably null Het
Wdtc1 C A 4: 133,033,271 (GRCm39) D176Y probably damaging Het
Other mutations in Nadk
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01551:Nadk APN 4 155,673,157 (GRCm39) splice site probably benign
IGL02116:Nadk APN 4 155,663,763 (GRCm39) splice site probably benign
IGL02951:Nadk APN 4 155,671,933 (GRCm39) missense probably benign 0.00
IGL03059:Nadk APN 4 155,671,253 (GRCm39) missense probably benign 0.02
IGL03203:Nadk APN 4 155,669,708 (GRCm39) missense probably damaging 0.99
R0416:Nadk UTSW 4 155,672,256 (GRCm39) splice site probably benign
R1633:Nadk UTSW 4 155,661,642 (GRCm39) missense probably damaging 1.00
R2044:Nadk UTSW 4 155,669,898 (GRCm39) missense probably damaging 1.00
R2891:Nadk UTSW 4 155,671,817 (GRCm39) missense possibly damaging 0.46
R2892:Nadk UTSW 4 155,671,817 (GRCm39) missense possibly damaging 0.46
R2894:Nadk UTSW 4 155,671,817 (GRCm39) missense possibly damaging 0.46
R4275:Nadk UTSW 4 155,668,712 (GRCm39) missense probably benign 0.44
R4386:Nadk UTSW 4 155,667,032 (GRCm39) unclassified probably benign
R4416:Nadk UTSW 4 155,672,183 (GRCm39) nonsense probably null
R4703:Nadk UTSW 4 155,669,684 (GRCm39) missense probably benign 0.00
R4704:Nadk UTSW 4 155,669,684 (GRCm39) missense probably benign 0.00
R4705:Nadk UTSW 4 155,669,684 (GRCm39) missense probably benign 0.00
R5219:Nadk UTSW 4 155,668,711 (GRCm39) missense probably benign 0.00
R5610:Nadk UTSW 4 155,668,628 (GRCm39) missense probably damaging 1.00
R5673:Nadk UTSW 4 155,669,642 (GRCm39) missense possibly damaging 0.48
R6393:Nadk UTSW 4 155,673,808 (GRCm39) missense possibly damaging 0.60
R7091:Nadk UTSW 4 155,672,215 (GRCm39) missense probably benign 0.00
R7144:Nadk UTSW 4 155,673,793 (GRCm39) missense probably damaging 0.99
R7811:Nadk UTSW 4 155,661,332 (GRCm39) intron probably benign
R7951:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R7952:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8002:Nadk UTSW 4 155,661,655 (GRCm39) critical splice donor site probably null
R8039:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8041:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8042:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8066:Nadk UTSW 4 155,661,524 (GRCm39) missense probably benign 0.06
R8113:Nadk UTSW 4 155,655,127 (GRCm39) splice site probably null
R8558:Nadk UTSW 4 155,669,844 (GRCm39) missense probably benign 0.40
R9122:Nadk UTSW 4 155,671,275 (GRCm39) missense probably benign 0.00
Z1177:Nadk UTSW 4 155,672,157 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16