Incidental Mutation 'IGL02082:Gpr63'
| ID |
283410 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr63
|
| Ensembl Gene |
ENSMUSG00000040372 |
| Gene Name |
G protein-coupled receptor 63 |
| Synonyms |
PSP24beta |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02082
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
24966407-25009233 bp(+) (GRCm39) |
| Type of Mutation |
utr 3 prime |
| DNA Base Change (assembly) |
A to G
at 25008564 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000039312
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038920]
|
| AlphaFold |
Q9EQQ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000038920
|
| SMART Domains |
Protein: ENSMUSP00000039312
Gene: ENSMUSG00000040372
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srsx
|
98 |
392 |
1.3e-8 |
PFAM |
|
Pfam:7tm_1
|
104 |
377 |
1.9e-49 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124792
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151006
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp9b |
A |
C |
18: 80,935,145 (GRCm39) |
|
probably benign |
Het |
| Brinp3 |
T |
C |
1: 146,627,600 (GRCm39) |
C278R |
probably damaging |
Het |
| Cfap54 |
T |
C |
10: 92,917,320 (GRCm39) |
S47G |
unknown |
Het |
| Clec16a |
T |
C |
16: 10,432,432 (GRCm39) |
L484P |
probably damaging |
Het |
| Cnksr1 |
C |
A |
4: 133,963,363 (GRCm39) |
G71C |
probably damaging |
Het |
| Dnah12 |
A |
T |
14: 26,428,317 (GRCm39) |
N246I |
possibly damaging |
Het |
| Fbh1 |
T |
C |
2: 11,768,938 (GRCm39) |
D285G |
probably benign |
Het |
| Focad |
C |
T |
4: 88,148,815 (GRCm39) |
Q511* |
probably null |
Het |
| Iah1 |
C |
A |
12: 21,367,405 (GRCm39) |
S37* |
probably null |
Het |
| Inpp4a |
T |
A |
1: 37,405,708 (GRCm39) |
|
probably benign |
Het |
| Mcm2 |
A |
T |
6: 88,865,218 (GRCm39) |
Y486* |
probably null |
Het |
| Mtmr10 |
A |
G |
7: 63,983,238 (GRCm39) |
|
probably benign |
Het |
| Nbea |
A |
G |
3: 55,875,588 (GRCm39) |
L1694S |
possibly damaging |
Het |
| Pafah1b1 |
A |
G |
11: 74,590,159 (GRCm39) |
S4P |
probably benign |
Het |
| Rnase10 |
A |
T |
14: 51,246,856 (GRCm39) |
E41V |
probably damaging |
Het |
| Slc17a6 |
G |
T |
7: 51,318,777 (GRCm39) |
R473L |
probably benign |
Het |
| Spata31g1 |
A |
G |
4: 42,970,198 (GRCm39) |
T2A |
probably benign |
Het |
| Tbc1d9b |
A |
G |
11: 50,054,709 (GRCm39) |
D951G |
probably benign |
Het |
| Tk1 |
C |
A |
11: 117,716,553 (GRCm39) |
|
probably null |
Het |
| Trim46 |
C |
A |
3: 89,146,307 (GRCm39) |
A395S |
probably benign |
Het |
| Vmn1r113 |
C |
T |
7: 20,521,672 (GRCm39) |
H155Y |
probably benign |
Het |
| Vmn1r222 |
A |
G |
13: 23,416,499 (GRCm39) |
M238T |
probably damaging |
Het |
| Vmn2r72 |
A |
T |
7: 85,387,374 (GRCm39) |
V730E |
probably benign |
Het |
|
| Other mutations in Gpr63 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01576:Gpr63
|
APN |
4 |
25,008,445 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01673:Gpr63
|
APN |
4 |
25,008,014 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01861:Gpr63
|
APN |
4 |
25,008,545 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0003:Gpr63
|
UTSW |
4 |
25,007,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Gpr63
|
UTSW |
4 |
25,007,447 (GRCm39) |
missense |
probably benign |
|
|
R0729:Gpr63
|
UTSW |
4 |
25,007,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1506:Gpr63
|
UTSW |
4 |
25,008,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3103:Gpr63
|
UTSW |
4 |
25,007,353 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3694:Gpr63
|
UTSW |
4 |
25,007,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4021:Gpr63
|
UTSW |
4 |
25,008,470 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R4807:Gpr63
|
UTSW |
4 |
25,007,446 (GRCm39) |
missense |
probably benign |
|
|
R4967:Gpr63
|
UTSW |
4 |
25,008,368 (GRCm39) |
nonsense |
probably null |
|
|
R5047:Gpr63
|
UTSW |
4 |
25,008,202 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5325:Gpr63
|
UTSW |
4 |
25,007,294 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5382:Gpr63
|
UTSW |
4 |
25,007,952 (GRCm39) |
missense |
probably benign |
|
|
R7047:Gpr63
|
UTSW |
4 |
25,007,320 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7216:Gpr63
|
UTSW |
4 |
25,008,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Gpr63
|
UTSW |
4 |
25,008,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8387:Gpr63
|
UTSW |
4 |
25,008,301 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8989:Gpr63
|
UTSW |
4 |
25,007,357 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R9324:Gpr63
|
UTSW |
4 |
25,008,432 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
| Posted On |
2015-04-16 |
Incidental Mutation