Incidental Mutation 'IGL02083:Fmo6'
| ID |
283441 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fmo6
|
| Ensembl Gene |
ENSMUSG00000095576 |
| Gene Name |
flavin containing monooxygenase 6 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
IGL02083
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
162744120-162765084 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 162748033 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 344
(K344*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136378
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000178465]
[ENSMUST00000195576]
|
| AlphaFold |
J3QMN6 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000178465
AA Change: K344*
|
| SMART Domains |
Protein: ENSMUSP00000136378
Gene: ENSMUSG00000095576
AA Change: K344*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FMO-like
|
2 |
532 |
3.2e-273 |
PFAM |
|
Pfam:Pyr_redox_2
|
3 |
226 |
2e-13 |
PFAM |
|
Pfam:Pyr_redox_3
|
6 |
220 |
4.6e-17 |
PFAM |
|
Pfam:K_oxygenase
|
79 |
223 |
1e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195576
|
| SMART Domains |
Protein: ENSMUSP00000144106
Gene: ENSMUSG00000095576
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:FMO-like
|
2 |
118 |
5.1e-58 |
PFAM |
|
Pfam:NAD_binding_8
|
7 |
84 |
2.2e-5 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acap1 |
A |
C |
11: 69,780,336 (GRCm39) |
L36V |
possibly damaging |
Het |
| Aoc1l1 |
G |
A |
6: 48,953,194 (GRCm39) |
G373D |
probably damaging |
Het |
| Atp13a3 |
T |
C |
16: 30,166,524 (GRCm39) |
T540A |
possibly damaging |
Het |
| Bend5 |
A |
C |
4: 111,316,964 (GRCm39) |
I376L |
probably benign |
Het |
| Ccdc138 |
T |
C |
10: 58,380,736 (GRCm39) |
|
probably benign |
Het |
| Cdh10 |
T |
A |
15: 18,986,975 (GRCm39) |
I402N |
possibly damaging |
Het |
| Cfap44 |
T |
C |
16: 44,257,525 (GRCm39) |
V1020A |
probably damaging |
Het |
| Chd2 |
A |
T |
7: 73,130,816 (GRCm39) |
S749T |
possibly damaging |
Het |
| Enpp3 |
T |
A |
10: 24,652,692 (GRCm39) |
D755V |
probably damaging |
Het |
| Gabbr1 |
A |
G |
17: 37,380,957 (GRCm39) |
T767A |
possibly damaging |
Het |
| Gjd3 |
A |
G |
11: 98,873,587 (GRCm39) |
S86P |
probably damaging |
Het |
| Grin1 |
A |
G |
2: 25,188,513 (GRCm39) |
V432A |
possibly damaging |
Het |
| Igf2r |
A |
T |
17: 12,912,079 (GRCm39) |
C1849* |
probably null |
Het |
| Jcad |
G |
T |
18: 4,680,266 (GRCm39) |
|
probably benign |
Het |
| Mrgpra4 |
A |
T |
7: 47,630,808 (GRCm39) |
C264* |
probably null |
Het |
| Naa80 |
G |
T |
9: 107,460,798 (GRCm39) |
R231L |
probably benign |
Het |
| Napepld |
T |
C |
5: 21,881,065 (GRCm39) |
Y110C |
probably damaging |
Het |
| Ncapd3 |
A |
G |
9: 26,963,117 (GRCm39) |
E474G |
probably damaging |
Het |
| Pkhd1 |
T |
A |
1: 20,271,451 (GRCm39) |
D3034V |
probably damaging |
Het |
| Plxnc1 |
T |
C |
10: 94,758,587 (GRCm39) |
T370A |
possibly damaging |
Het |
| Ptger4 |
C |
T |
15: 5,272,655 (GRCm39) |
R13H |
probably benign |
Het |
| Scg2 |
T |
A |
1: 79,413,941 (GRCm39) |
T261S |
probably benign |
Het |
| Sfswap |
T |
C |
5: 129,616,855 (GRCm39) |
V433A |
probably benign |
Het |
| Sipa1l3 |
A |
G |
7: 29,086,686 (GRCm39) |
Y635H |
probably damaging |
Het |
| Sp5 |
C |
A |
2: 70,306,758 (GRCm39) |
P148T |
possibly damaging |
Het |
| Tlr5 |
A |
G |
1: 182,801,449 (GRCm39) |
N251S |
possibly damaging |
Het |
| Tmem87a |
A |
T |
2: 120,227,861 (GRCm39) |
N95K |
probably damaging |
Het |
| Unc45b |
C |
T |
11: 82,813,745 (GRCm39) |
T384M |
probably damaging |
Het |
| Unc5c |
T |
C |
3: 141,420,408 (GRCm39) |
L117P |
probably damaging |
Het |
| Vcan |
T |
C |
13: 89,873,684 (GRCm39) |
N57D |
probably damaging |
Het |
| Zcchc8 |
G |
T |
5: 123,838,981 (GRCm39) |
T519K |
probably damaging |
Het |
| Zfp729b |
G |
A |
13: 67,743,349 (GRCm39) |
T72I |
probably benign |
Het |
|
| Other mutations in Fmo6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01392:Fmo6
|
APN |
1 |
162,757,580 (GRCm39) |
nonsense |
probably null |
|
|
adventure
|
UTSW |
1 |
162,750,379 (GRCm39) |
missense |
probably benign |
|
|
R0792:Fmo6
|
UTSW |
1 |
162,748,132 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0940:Fmo6
|
UTSW |
1 |
162,753,795 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1173:Fmo6
|
UTSW |
1 |
162,753,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1268:Fmo6
|
UTSW |
1 |
162,748,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1538:Fmo6
|
UTSW |
1 |
162,753,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1694:Fmo6
|
UTSW |
1 |
162,750,241 (GRCm39) |
missense |
probably benign |
|
|
R1717:Fmo6
|
UTSW |
1 |
162,753,821 (GRCm39) |
nonsense |
probably null |
|
|
R1837:Fmo6
|
UTSW |
1 |
162,750,379 (GRCm39) |
missense |
probably benign |
|
|
R2125:Fmo6
|
UTSW |
1 |
162,757,527 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R2434:Fmo6
|
UTSW |
1 |
162,744,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2894:Fmo6
|
UTSW |
1 |
162,750,293 (GRCm39) |
nonsense |
probably null |
|
|
R4864:Fmo6
|
UTSW |
1 |
162,751,964 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6414:Fmo6
|
UTSW |
1 |
162,748,014 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6576:Fmo6
|
UTSW |
1 |
162,750,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6883:Fmo6
|
UTSW |
1 |
162,757,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7013:Fmo6
|
UTSW |
1 |
162,745,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7014:Fmo6
|
UTSW |
1 |
162,753,877 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7657:Fmo6
|
UTSW |
1 |
162,750,285 (GRCm39) |
missense |
probably benign |
|
|
R8351:Fmo6
|
UTSW |
1 |
162,748,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8451:Fmo6
|
UTSW |
1 |
162,748,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8911:Fmo6
|
UTSW |
1 |
162,748,114 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9217:Fmo6
|
UTSW |
1 |
162,748,046 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9274:Fmo6
|
UTSW |
1 |
162,747,921 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0025:Fmo6
|
UTSW |
1 |
162,750,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0025:Fmo6
|
UTSW |
1 |
162,748,065 (GRCm39) |
missense |
probably benign |
0.29 |
|
Z1176:Fmo6
|
UTSW |
1 |
162,753,701 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation