Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02084:Actr10'

283460

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Actr10

Ensembl Gene

ENSMUSG00000021076

Gene Name

ARP10 actin-related protein 10

Synonyms

Arp11

Accession Numbers

Essential gene?

Probably essential (E-score: 0.963) question?

Stock #

IGL02084

Quality Score

Status

Chromosome

Chromosomal Location

70984631-71011492 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 71001423 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 210 (I210T)

Ref Sequence

ENSEMBL: ENSMUSP00000021479 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021479] [ENSMUST00000220582] [ENSMUST00000223549]

AlphaFold

Q9QZB7

Predicted Effect

probably damaging
Transcript: ENSMUST00000021479
AA Change: I210T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000021479
Gene: ENSMUSG00000021076
AA Change: I210T

Domain	Start	End	E-Value	Type
ACTIN	13	394	3e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220582

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220770

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221583

Predicted Effect

probably benign
Transcript: ENSMUST00000223549

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 110,021,423 (GRCm39)	F1096L	probably benign	Het
Abcd2	T	A	15: 91,062,530 (GRCm39)		probably null	Het
Apoa5	A	T	9: 46,181,950 (GRCm39)	D342V	probably damaging	Het
Bicra	G	A	7: 15,721,663 (GRCm39)	T618I	probably benign	Het
Birc6	C	A	17: 74,915,277 (GRCm39)	Q1642K	probably benign	Het
Cenpn	A	G	8: 117,667,634 (GRCm39)	Y331C	probably damaging	Het
Clcn7	T	A	17: 25,376,899 (GRCm39)	I624N	probably benign	Het
Eddm3b	A	T	14: 51,354,087 (GRCm39)	H25L	unknown	Het
Fam90a1a	A	G	8: 22,449,313 (GRCm39)	E19G	probably benign	Het
Fbh1	T	C	2: 11,768,938 (GRCm39)	D285G	probably benign	Het
Fbxo41	A	T	6: 85,457,747 (GRCm39)		probably null	Het
Frem3	A	G	8: 81,339,072 (GRCm39)	D455G	possibly damaging	Het
Gart	T	C	16: 91,418,488 (GRCm39)	Q86R	probably benign	Het
Gm45234	T	C	6: 124,724,658 (GRCm39)		probably benign	Het
Gm5431	C	T	11: 48,779,912 (GRCm39)	D337N	probably benign	Het
Gm6882	T	A	7: 21,161,512 (GRCm39)	I119F	probably damaging	Het
Kcns3	C	T	12: 11,142,195 (GRCm39)	R168Q	probably damaging	Het
Klra17	T	A	6: 129,808,556 (GRCm39)	N226Y	probably damaging	Het
Macf1	T	C	4: 123,326,396 (GRCm39)	N2915D	probably benign	Het
Macf1	T	C	4: 123,353,167 (GRCm39)	D1504G	probably damaging	Het
Mgat4d	C	T	8: 84,095,610 (GRCm39)	S295L	possibly damaging	Het
Mslnl	T	C	17: 25,965,125 (GRCm39)	V497A	probably benign	Het
Mtor	T	C	4: 148,555,137 (GRCm39)	S920P	probably damaging	Het
Mynn	C	A	3: 30,665,764 (GRCm39)	H465Q	probably damaging	Het
Myo16	A	G	8: 10,411,088 (GRCm39)	E182G	probably damaging	Het
Ncln	T	C	10: 81,324,430 (GRCm39)	I417V	probably benign	Het
Nlrp4f	A	T	13: 65,341,985 (GRCm39)	C553*	probably null	Het
Or5k14	G	A	16: 58,693,399 (GRCm39)	T38I	probably damaging	Het
Or8k37	T	A	2: 86,469,980 (GRCm39)	Q24L	possibly damaging	Het
Pkhd1	T	C	1: 20,447,623 (GRCm39)	I2257V	probably damaging	Het
Ppp4r4	T	A	12: 103,566,657 (GRCm39)	S35T	possibly damaging	Het
Qrfprl	T	C	6: 65,358,594 (GRCm39)	V106A	probably benign	Het
Rnf213	T	C	11: 119,336,499 (GRCm39)	V3291A	probably benign	Het
Runx2	C	T	17: 45,035,716 (GRCm39)	A173T	probably damaging	Het
Ryr2	A	T	13: 11,807,648 (GRCm39)	Y833*	probably null	Het
Setbp1	G	A	18: 78,900,625 (GRCm39)	A1014V	probably damaging	Het
Slc25a38	A	G	9: 119,949,512 (GRCm39)		probably benign	Het
Stk4	A	G	2: 163,928,527 (GRCm39)	T120A	probably benign	Het
Taf3	A	T	2: 10,047,330 (GRCm39)	V106D	probably benign	Het
Uchl5	A	G	1: 143,677,912 (GRCm39)	I139V	possibly damaging	Het
Ung	A	G	5: 114,268,637 (GRCm39)	E25G	probably benign	Het
Wrn	A	G	8: 33,775,207 (GRCm39)	V619A	probably benign	Het

Other mutations in Actr10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02232:Actr10	APN	12	70,990,289 (GRCm39)	missense	probably benign	0.05
IGL02628:Actr10	APN	12	71,001,430 (GRCm39)	critical splice donor site	probably null
IGL03202:Actr10	APN	12	70,987,605 (GRCm39)	missense	probably damaging	0.99
IGL03266:Actr10	APN	12	71,003,440 (GRCm39)	missense	probably benign	0.00
R0505:Actr10	UTSW	12	71,006,738 (GRCm39)	missense	probably damaging	1.00
R1734:Actr10	UTSW	12	71,008,770 (GRCm39)	missense	probably benign	0.23
R1919:Actr10	UTSW	12	70,989,104 (GRCm39)	missense	probably benign	0.00
R2151:Actr10	UTSW	12	70,987,575 (GRCm39)	nonsense	probably null
R2201:Actr10	UTSW	12	71,006,795 (GRCm39)	missense	probably damaging	0.97
R4259:Actr10	UTSW	12	70,999,759 (GRCm39)	missense	probably benign	0.02
R4261:Actr10	UTSW	12	70,999,759 (GRCm39)	missense	probably benign	0.02
R5138:Actr10	UTSW	12	71,008,653 (GRCm39)	missense	probably damaging	1.00
R5326:Actr10	UTSW	12	71,001,430 (GRCm39)	unclassified	probably benign
R5542:Actr10	UTSW	12	71,001,430 (GRCm39)	unclassified	probably benign
R6248:Actr10	UTSW	12	70,999,733 (GRCm39)	missense	probably benign	0.00
R6882:Actr10	UTSW	12	71,003,125 (GRCm39)	missense	probably benign	0.00
R7102:Actr10	UTSW	12	70,999,805 (GRCm39)	critical splice donor site	probably null
R7758:Actr10	UTSW	12	70,989,100 (GRCm39)	missense	probably damaging	1.00
R7800:Actr10	UTSW	12	70,990,283 (GRCm39)	missense	probably benign	0.26
R8766:Actr10	UTSW	12	71,001,430 (GRCm39)	critical splice donor site	probably null
R8850:Actr10	UTSW	12	70,989,032 (GRCm39)	critical splice acceptor site	probably null
R9011:Actr10	UTSW	12	70,999,734 (GRCm39)	missense	probably benign	0.01
R9068:Actr10	UTSW	12	70,989,073 (GRCm39)	missense	probably damaging	1.00
R9229:Actr10	UTSW	12	70,990,259 (GRCm39)	missense	probably damaging	1.00
R9452:Actr10	UTSW	12	71,006,818 (GRCm39)	critical splice donor site	probably null
X0012:Actr10	UTSW	12	70,987,639 (GRCm39)	missense	probably benign	0.04
X0027:Actr10	UTSW	12	71,006,733 (GRCm39)	missense	possibly damaging	0.94
Z1176:Actr10	UTSW	12	71,008,803 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16