Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02085:Ifi44l'

283508

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi44l

Ensembl Gene

ENSMUSG00000039146

Gene Name

interferon-induced protein 44 like

Synonyms

H-28, NS1178, H28

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL02085

Quality Score

Status

Chromosome

Chromosomal Location

151464374-151468528 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 151468477 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 18 (S18P)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000046739
AA Change: S18P

SMART Domains

Protein: ENSMUSP00000044765
Gene: ENSMUSG00000039146
AA Change: S18P

Domain	Start	End	E-Value	Type
low complexity region	140	154	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a minor histocompatibility antigen that is involved in tissue graft rejection and is polymorphic in different mouse strains. The 5' region of this gene, including the translational start codon and the first 293 amino acids, is absent from the C57BL/6J genome. The encoded antigen is not thought to be expressed in C57BL/6J. [provided by RefSeq, Mar 2013]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg4	A	G	9: 44,192,854 (GRCm39)		probably null	Het
Akr1c14	T	A	13: 4,128,035 (GRCm39)	C145*	probably null	Het
Arhgef26	A	G	3: 62,367,145 (GRCm39)		probably benign	Het
Asb9	A	G	X: 163,318,452 (GRCm39)	M215V	probably benign	Het
Atoh8	C	A	6: 72,212,157 (GRCm39)		probably benign	Het
Atp6v1b1	T	A	6: 83,730,897 (GRCm39)		probably benign	Het
Cep97	T	C	16: 55,735,868 (GRCm39)	E310G	probably damaging	Het
Ctrc	C	T	4: 141,571,025 (GRCm39)	D72N	possibly damaging	Het
Dnah2	A	G	11: 69,349,011 (GRCm39)	I2492T	probably benign	Het
Emilin2	A	G	17: 71,582,144 (GRCm39)	V194A	probably damaging	Het
Epb41l5	T	C	1: 119,500,586 (GRCm39)	T524A	probably benign	Het
Fam91a1	A	G	15: 58,313,505 (GRCm39)	N497S	possibly damaging	Het
Gabpb1	A	T	2: 126,481,191 (GRCm39)	C319*	probably null	Het
Galnt10	A	G	11: 57,673,104 (GRCm39)	T487A	probably benign	Het
Hecw2	T	A	1: 53,981,961 (GRCm39)		probably null	Het
Hmg20a	C	T	9: 56,384,586 (GRCm39)	Q119*	probably null	Het
Immt	T	A	6: 71,828,820 (GRCm39)	V125E	probably benign	Het
Ints13	T	C	6: 146,451,437 (GRCm39)		probably benign	Het
Lrp1b	C	T	2: 40,779,321 (GRCm39)	G2574S	probably benign	Het
Myoc	T	C	1: 162,467,343 (GRCm39)	C171R	probably benign	Het
Ncbp1	C	T	4: 46,159,699 (GRCm39)	T404M	probably damaging	Het
Npy6r	A	G	18: 44,408,998 (GRCm39)	N140D	probably damaging	Het
Nrxn2	A	T	19: 6,542,898 (GRCm39)	M1041L	possibly damaging	Het
Nsmaf	G	A	4: 6,398,551 (GRCm39)	P851L	probably benign	Het
Nutm2	T	A	13: 50,627,829 (GRCm39)		probably null	Het
Or10ak8	A	G	4: 118,773,947 (GRCm39)	F239S	probably damaging	Het
Or2g25	A	G	17: 37,970,579 (GRCm39)	V215A	probably benign	Het
Or4f61	A	C	2: 111,922,869 (GRCm39)	M59R	probably damaging	Het
Padi2	T	G	4: 140,654,468 (GRCm39)	Y206*	probably null	Het
Pcdh19	A	T	X: 132,582,007 (GRCm39)	Y766*	probably null	Het
Pde12	A	G	14: 26,387,619 (GRCm39)		probably benign	Het
Ppl	C	T	16: 4,907,680 (GRCm39)	G872R	probably benign	Het
Prkag3	C	T	1: 74,787,971 (GRCm39)		probably benign	Het
Ptgfr	T	C	3: 151,541,437 (GRCm39)	T24A	probably benign	Het
Rpe65	T	C	3: 159,321,283 (GRCm39)	V365A	probably benign	Het
Shank3	T	C	15: 89,388,118 (GRCm39)		probably null	Het
Slco1a6	T	C	6: 142,032,200 (GRCm39)	T642A	probably benign	Het
Slco6d1	C	A	1: 98,371,468 (GRCm39)	P275T	probably damaging	Het
Smarca1	G	T	X: 46,964,109 (GRCm39)	Q343K	probably damaging	Het
Smoc2	A	G	17: 14,567,495 (GRCm39)	T180A	possibly damaging	Het
Tfrc	G	A	16: 32,440,004 (GRCm39)	V406I	probably benign	Het
Tigit	C	T	16: 43,469,473 (GRCm39)	G206D	probably benign	Het
Triobp	G	A	15: 78,858,497 (GRCm39)		probably benign	Het
Trmo	T	C	4: 46,380,217 (GRCm39)	Y384C	probably damaging	Het
Vmn1r89	T	A	7: 12,953,465 (GRCm39)	I67N	probably damaging	Het
Wdr17	C	A	8: 55,140,771 (GRCm39)	E194*	probably null	Het

Other mutations in Ifi44l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0638:Ifi44l	UTSW	3	151,468,396 (GRCm39)	missense	probably benign	0.13
R1729:Ifi44l	UTSW	3	151,468,456 (GRCm39)	missense	unknown
R3087:Ifi44l	UTSW	3	151,468,494 (GRCm39)	missense	unknown
R4229:Ifi44l	UTSW	3	151,468,514 (GRCm39)	nonsense	probably null
R4230:Ifi44l	UTSW	3	151,468,514 (GRCm39)	nonsense	probably null
R4812:Ifi44l	UTSW	3	151,465,336 (GRCm39)	missense	probably benign	0.00
R5547:Ifi44l	UTSW	3	151,467,142 (GRCm39)	missense	unknown
R6365:Ifi44l	UTSW	3	151,467,142 (GRCm39)	missense	unknown
R7065:Ifi44l	UTSW	3	151,465,429 (GRCm39)	missense
R9796:Ifi44l	UTSW	3	151,468,419 (GRCm39)	missense

Posted On

2015-04-16