Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02085:Ptgfr'

283517

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ptgfr

Ensembl Gene

ENSMUSG00000028036

Gene Name

prostaglandin F receptor

Synonyms

FP, PGF

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

IGL02085

Quality Score

Status

Chromosome

Chromosomal Location

151504247-151543165 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 151541437 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 24 (T24A)

Ref Sequence

ENSEMBL: ENSMUSP00000101732 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029670] [ENSMUST00000106126]

AlphaFold

P43117

Predicted Effect

probably benign
Transcript: ENSMUST00000029670
AA Change: T24A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000029670
Gene: ENSMUSG00000028036
AA Change: T24A

Domain	Start	End	E-Value	Type
Pfam:7tm_1	23	304	6.8e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106126
AA Change: T24A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000101732
Gene: ENSMUSG00000028036
AA Change: T24A

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	304	7.6e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128349

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197392

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Pregnant females homozygous for a targeted null mutation are unable to deliver their offspring due to lack of induction of the oxytocin receptor and fail to show the normal decline of serum progesterone levels preceding parturition. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg4	A	G	9: 44,192,854 (GRCm39)		probably null	Het
Akr1c14	T	A	13: 4,128,035 (GRCm39)	C145*	probably null	Het
Arhgef26	A	G	3: 62,367,145 (GRCm39)		probably benign	Het
Asb9	A	G	X: 163,318,452 (GRCm39)	M215V	probably benign	Het
Atoh8	C	A	6: 72,212,157 (GRCm39)		probably benign	Het
Atp6v1b1	T	A	6: 83,730,897 (GRCm39)		probably benign	Het
Cep97	T	C	16: 55,735,868 (GRCm39)	E310G	probably damaging	Het
Ctrc	C	T	4: 141,571,025 (GRCm39)	D72N	possibly damaging	Het
Dnah2	A	G	11: 69,349,011 (GRCm39)	I2492T	probably benign	Het
Emilin2	A	G	17: 71,582,144 (GRCm39)	V194A	probably damaging	Het
Epb41l5	T	C	1: 119,500,586 (GRCm39)	T524A	probably benign	Het
Fam91a1	A	G	15: 58,313,505 (GRCm39)	N497S	possibly damaging	Het
Gabpb1	A	T	2: 126,481,191 (GRCm39)	C319*	probably null	Het
Galnt10	A	G	11: 57,673,104 (GRCm39)	T487A	probably benign	Het
Hecw2	T	A	1: 53,981,961 (GRCm39)		probably null	Het
Hmg20a	C	T	9: 56,384,586 (GRCm39)	Q119*	probably null	Het
Ifi44l	A	G	3: 151,468,477 (GRCm39)	S18P	unknown	Het
Immt	T	A	6: 71,828,820 (GRCm39)	V125E	probably benign	Het
Ints13	T	C	6: 146,451,437 (GRCm39)		probably benign	Het
Lrp1b	C	T	2: 40,779,321 (GRCm39)	G2574S	probably benign	Het
Myoc	T	C	1: 162,467,343 (GRCm39)	C171R	probably benign	Het
Ncbp1	C	T	4: 46,159,699 (GRCm39)	T404M	probably damaging	Het
Npy6r	A	G	18: 44,408,998 (GRCm39)	N140D	probably damaging	Het
Nrxn2	A	T	19: 6,542,898 (GRCm39)	M1041L	possibly damaging	Het
Nsmaf	G	A	4: 6,398,551 (GRCm39)	P851L	probably benign	Het
Nutm2	T	A	13: 50,627,829 (GRCm39)		probably null	Het
Or10ak8	A	G	4: 118,773,947 (GRCm39)	F239S	probably damaging	Het
Or2g25	A	G	17: 37,970,579 (GRCm39)	V215A	probably benign	Het
Or4f61	A	C	2: 111,922,869 (GRCm39)	M59R	probably damaging	Het
Padi2	T	G	4: 140,654,468 (GRCm39)	Y206*	probably null	Het
Pcdh19	A	T	X: 132,582,007 (GRCm39)	Y766*	probably null	Het
Pde12	A	G	14: 26,387,619 (GRCm39)		probably benign	Het
Ppl	C	T	16: 4,907,680 (GRCm39)	G872R	probably benign	Het
Prkag3	C	T	1: 74,787,971 (GRCm39)		probably benign	Het
Rpe65	T	C	3: 159,321,283 (GRCm39)	V365A	probably benign	Het
Shank3	T	C	15: 89,388,118 (GRCm39)		probably null	Het
Slco1a6	T	C	6: 142,032,200 (GRCm39)	T642A	probably benign	Het
Slco6d1	C	A	1: 98,371,468 (GRCm39)	P275T	probably damaging	Het
Smarca1	G	T	X: 46,964,109 (GRCm39)	Q343K	probably damaging	Het
Smoc2	A	G	17: 14,567,495 (GRCm39)	T180A	possibly damaging	Het
Tfrc	G	A	16: 32,440,004 (GRCm39)	V406I	probably benign	Het
Tigit	C	T	16: 43,469,473 (GRCm39)	G206D	probably benign	Het
Triobp	G	A	15: 78,858,497 (GRCm39)		probably benign	Het
Trmo	T	C	4: 46,380,217 (GRCm39)	Y384C	probably damaging	Het
Vmn1r89	T	A	7: 12,953,465 (GRCm39)	I67N	probably damaging	Het
Wdr17	C	A	8: 55,140,771 (GRCm39)	E194*	probably null	Het

Other mutations in Ptgfr

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01322:Ptgfr	APN	3	151,541,323 (GRCm39)	missense	probably benign	0.43
IGL02110:Ptgfr	APN	3	151,541,097 (GRCm39)	missense	probably damaging	0.97
IGL02971:Ptgfr	APN	3	151,540,963 (GRCm39)	missense	probably benign	0.00
IGL03263:Ptgfr	APN	3	151,541,500 (GRCm39)	missense	probably benign	0.00
R0048:Ptgfr	UTSW	3	151,540,728 (GRCm39)	missense	possibly damaging	0.51
R0048:Ptgfr	UTSW	3	151,540,728 (GRCm39)	missense	possibly damaging	0.51
R0602:Ptgfr	UTSW	3	151,540,839 (GRCm39)	missense	probably damaging	1.00
R0624:Ptgfr	UTSW	3	151,540,839 (GRCm39)	missense	probably damaging	1.00
R0633:Ptgfr	UTSW	3	151,507,400 (GRCm39)	missense	probably benign	0.00
R1614:Ptgfr	UTSW	3	151,507,416 (GRCm39)	missense	probably benign	0.44
R1930:Ptgfr	UTSW	3	151,540,831 (GRCm39)	missense	probably benign	0.16
R1931:Ptgfr	UTSW	3	151,540,831 (GRCm39)	missense	probably benign	0.16
R1989:Ptgfr	UTSW	3	151,540,976 (GRCm39)	nonsense	probably null
R4596:Ptgfr	UTSW	3	151,507,430 (GRCm39)	missense	probably damaging	1.00
R5899:Ptgfr	UTSW	3	151,540,738 (GRCm39)	missense	probably damaging	0.96
R6295:Ptgfr	UTSW	3	151,540,926 (GRCm39)	missense	probably benign	0.00
R6907:Ptgfr	UTSW	3	151,540,938 (GRCm39)	missense	possibly damaging	0.95
R7047:Ptgfr	UTSW	3	151,541,178 (GRCm39)	missense	possibly damaging	0.74
R7320:Ptgfr	UTSW	3	151,541,034 (GRCm39)	missense	probably benign	0.22
R8205:Ptgfr	UTSW	3	151,541,418 (GRCm39)	missense	probably benign	0.04
R8420:Ptgfr	UTSW	3	151,541,053 (GRCm39)	missense	possibly damaging	0.49
R9049:Ptgfr	UTSW	3	151,541,404 (GRCm39)	missense	probably benign	0.24
R9352:Ptgfr	UTSW	3	151,541,160 (GRCm39)	missense	probably damaging	1.00
R9537:Ptgfr	UTSW	3	151,541,445 (GRCm39)	missense	possibly damaging	0.91
Z1176:Ptgfr	UTSW	3	151,541,278 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16