Incidental Mutation 'IGL02171:Vmn1r173'
| ID |
283551 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r173
|
| Ensembl Gene |
ENSMUSG00000115021 |
| Gene Name |
vomeronasal 1 receptor 173 |
| Synonyms |
Gm5892 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.670)
|
| Stock # |
IGL02171
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23401767-23402708 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 23402321 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 185
(M185I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153884
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000174055]
[ENSMUST00000226233]
[ENSMUST00000227987]
|
| AlphaFold |
E9Q8V7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174055
AA Change: M185I
PolyPhen 2
Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: M185I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
13 |
35 |
N/A |
INTRINSIC |
|
Pfam:V1R
|
43 |
301 |
5.3e-20 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226233
AA Change: M185I
PolyPhen 2
Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227987
AA Change: M185I
PolyPhen 2
Score 0.040 (Sensitivity: 0.94; Specificity: 0.83)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930590J08Rik |
A |
G |
6: 91,921,237 (GRCm39) |
I772M |
probably benign |
Het |
| Abcg4 |
C |
A |
9: 44,186,306 (GRCm39) |
|
probably benign |
Het |
| Abo |
A |
G |
2: 26,738,969 (GRCm39) |
I18T |
probably benign |
Het |
| AI661453 |
C |
T |
17: 47,777,921 (GRCm39) |
|
probably benign |
Het |
| Apbb1 |
A |
G |
7: 105,208,333 (GRCm39) |
|
probably benign |
Het |
| Atp8a1 |
G |
A |
5: 67,895,808 (GRCm39) |
S557L |
probably damaging |
Het |
| Bora |
G |
T |
14: 99,284,758 (GRCm39) |
D3Y |
probably damaging |
Het |
| Cfap46 |
T |
C |
7: 139,246,972 (GRCm39) |
D323G |
possibly damaging |
Het |
| Dcdc2a |
T |
A |
13: 25,240,417 (GRCm39) |
V55E |
probably damaging |
Het |
| Dync1i1 |
G |
T |
6: 5,969,498 (GRCm39) |
R441L |
probably damaging |
Het |
| Ecd |
T |
A |
14: 20,370,895 (GRCm39) |
Y608F |
probably damaging |
Het |
| Eif4g3 |
A |
G |
4: 137,853,900 (GRCm39) |
T489A |
probably benign |
Het |
| Erlin1 |
A |
G |
19: 44,037,555 (GRCm39) |
|
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,883,040 (GRCm39) |
E2524G |
probably benign |
Het |
| Garem1 |
C |
T |
18: 21,262,298 (GRCm39) |
D839N |
probably damaging |
Het |
| Gdap1l1 |
T |
A |
2: 163,289,470 (GRCm39) |
V145E |
possibly damaging |
Het |
| Gvin3 |
G |
T |
7: 106,200,548 (GRCm39) |
|
noncoding transcript |
Het |
| Hydin |
A |
T |
8: 111,178,590 (GRCm39) |
K1062* |
probably null |
Het |
| Igkv4-92 |
T |
C |
6: 68,732,573 (GRCm39) |
D2G |
probably benign |
Het |
| Lemd3 |
T |
A |
10: 120,769,527 (GRCm39) |
|
probably benign |
Het |
| Mbl1 |
C |
T |
14: 40,876,455 (GRCm39) |
|
probably benign |
Het |
| Mdh1 |
T |
C |
11: 21,507,438 (GRCm39) |
|
probably benign |
Het |
| Mms19 |
A |
G |
19: 41,945,578 (GRCm39) |
|
probably null |
Het |
| Nrxn3 |
C |
A |
12: 89,159,933 (GRCm39) |
P20T |
probably damaging |
Het |
| Nudt1 |
A |
G |
5: 140,323,348 (GRCm39) |
E100G |
probably damaging |
Het |
| Or2y1e |
T |
A |
11: 49,218,862 (GRCm39) |
F208Y |
possibly damaging |
Het |
| Or9g4 |
T |
A |
2: 85,505,285 (GRCm39) |
D70V |
probably damaging |
Het |
| Palb2 |
A |
C |
7: 121,706,809 (GRCm39) |
S1083A |
probably damaging |
Het |
| Phc2 |
T |
G |
4: 128,604,858 (GRCm39) |
F198C |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,379,542 (GRCm39) |
D1056G |
possibly damaging |
Het |
| Psg17 |
A |
G |
7: 18,552,712 (GRCm39) |
Y188H |
probably damaging |
Het |
| Scn1a |
T |
A |
2: 66,103,543 (GRCm39) |
I1906F |
probably damaging |
Het |
| Sidt2 |
C |
A |
9: 45,864,068 (GRCm39) |
R150L |
possibly damaging |
Het |
| Slc39a10 |
G |
A |
1: 46,857,288 (GRCm39) |
A696V |
probably damaging |
Het |
| Supt3 |
T |
C |
17: 45,314,043 (GRCm39) |
I144T |
probably damaging |
Het |
| Trip4 |
A |
G |
9: 65,788,332 (GRCm39) |
S38P |
probably damaging |
Het |
| Vmn2r9 |
G |
A |
5: 108,991,502 (GRCm39) |
L620F |
probably damaging |
Het |
| Wdr72 |
A |
T |
9: 74,117,816 (GRCm39) |
M843L |
possibly damaging |
Het |
| Zfp595 |
T |
A |
13: 67,464,719 (GRCm39) |
N518Y |
possibly damaging |
Het |
|
| Other mutations in Vmn1r173 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01490:Vmn1r173
|
APN |
7 |
23,402,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01637:Vmn1r173
|
APN |
7 |
23,402,373 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01878:Vmn1r173
|
APN |
7 |
23,401,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02036:Vmn1r173
|
APN |
7 |
23,402,321 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02039:Vmn1r173
|
APN |
7 |
23,402,321 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02209:Vmn1r173
|
APN |
7 |
23,402,586 (GRCm39) |
missense |
probably benign |
0.25 |
|
PIT4515001:Vmn1r173
|
UTSW |
7 |
23,401,911 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Vmn1r173
|
UTSW |
7 |
23,401,822 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0226:Vmn1r173
|
UTSW |
7 |
23,402,508 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0482:Vmn1r173
|
UTSW |
7 |
23,402,216 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0792:Vmn1r173
|
UTSW |
7 |
23,402,160 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1242:Vmn1r173
|
UTSW |
7 |
23,402,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1390:Vmn1r173
|
UTSW |
7 |
23,402,323 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1641:Vmn1r173
|
UTSW |
7 |
23,402,533 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1867:Vmn1r173
|
UTSW |
7 |
23,402,660 (GRCm39) |
missense |
unknown |
|
|
R2325:Vmn1r173
|
UTSW |
7 |
23,402,537 (GRCm39) |
nonsense |
probably null |
|
|
R3863:Vmn1r173
|
UTSW |
7 |
23,401,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4407:Vmn1r173
|
UTSW |
7 |
23,402,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4717:Vmn1r173
|
UTSW |
7 |
23,402,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Vmn1r173
|
UTSW |
7 |
23,402,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Vmn1r173
|
UTSW |
7 |
23,402,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Vmn1r173
|
UTSW |
7 |
23,402,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6022:Vmn1r173
|
UTSW |
7 |
23,402,260 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6114:Vmn1r173
|
UTSW |
7 |
23,402,254 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6657:Vmn1r173
|
UTSW |
7 |
23,402,320 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7165:Vmn1r173
|
UTSW |
7 |
23,402,076 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn1r173
|
UTSW |
7 |
23,401,884 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7201:Vmn1r173
|
UTSW |
7 |
23,401,583 (GRCm39) |
start gained |
probably benign |
|
|
R7533:Vmn1r173
|
UTSW |
7 |
23,402,071 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7951:Vmn1r173
|
UTSW |
7 |
23,402,680 (GRCm39) |
missense |
unknown |
|
|
R8351:Vmn1r173
|
UTSW |
7 |
23,401,957 (GRCm39) |
nonsense |
probably null |
|
|
R8374:Vmn1r173
|
UTSW |
7 |
23,401,920 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8427:Vmn1r173
|
UTSW |
7 |
23,401,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8451:Vmn1r173
|
UTSW |
7 |
23,401,957 (GRCm39) |
nonsense |
probably null |
|
|
R8923:Vmn1r173
|
UTSW |
7 |
23,401,768 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9126:Vmn1r173
|
UTSW |
7 |
23,402,008 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9506:Vmn1r173
|
UTSW |
7 |
23,401,963 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9557:Vmn1r173
|
UTSW |
7 |
23,402,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Vmn1r173
|
UTSW |
7 |
23,402,012 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Posted On |
2015-04-16 |
Incidental Mutation