Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02185:Vmn2r85'

283577

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r85

Ensembl Gene

ENSMUSG00000092048

Gene Name

vomeronasal 2, receptor 85

Synonyms

EG623734

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

IGL02185

Quality Score

Status

Chromosome

Chromosomal Location

130253658-130266615 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 130254561 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Isoleucine at position 708 (L708I)

Ref Sequence

ENSEMBL: ENSMUSP00000128792 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171811]

AlphaFold

G3UW56

Predicted Effect

probably benign
Transcript: ENSMUST00000171811
AA Change: L708I

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: L708I

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	77	425	9e-26	PFAM
Pfam:NCD3G	508	562	1.1e-18	PFAM
Pfam:7tm_3	595	831	3.7e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adh5	A	G	3: 138,156,815 (GRCm39)	D167G	probably benign	Het
C9orf72	A	T	4: 35,197,046 (GRCm39)	W340R	probably damaging	Het
Cand2	G	A	6: 115,766,471 (GRCm39)	A359T	probably benign	Het
Cnnm2	T	C	19: 46,751,434 (GRCm39)	V408A	probably benign	Het
Eloa	A	G	4: 135,740,290 (GRCm39)		probably benign	Het
Ern2	T	C	7: 121,772,598 (GRCm39)		probably benign	Het
Hs6st3	A	G	14: 120,106,296 (GRCm39)		probably null	Het
Hydin	A	T	8: 111,233,108 (GRCm39)	I1736F	possibly damaging	Het
Ifrd2	A	T	9: 107,468,290 (GRCm39)	I253F	probably benign	Het
Kctd7	G	A	5: 130,181,299 (GRCm39)	V241I	possibly damaging	Het
Lcp1	T	C	14: 75,466,740 (GRCm39)	F616L	possibly damaging	Het
Lyst	C	T	13: 13,835,678 (GRCm39)	Q1787*	probably null	Het
Mapkbp1	A	T	2: 119,845,144 (GRCm39)	T342S	possibly damaging	Het
Mcph1	A	G	8: 18,719,006 (GRCm39)		probably benign	Het
Mctp2	T	C	7: 71,730,571 (GRCm39)	H868R	probably benign	Het
Mefv	T	C	16: 3,533,714 (GRCm39)	T186A	probably benign	Het
Nol9	T	A	4: 152,142,368 (GRCm39)	I666N	probably damaging	Het
Or51t4	T	A	7: 102,597,721 (GRCm39)	N16K	probably damaging	Het
Or6c205	G	T	10: 129,086,904 (GRCm39)	C167F	possibly damaging	Het
Or8b8	A	C	9: 37,809,531 (GRCm39)	Y277S	probably damaging	Het
Pum2	T	C	12: 8,798,955 (GRCm39)		probably null	Het
Rpgrip1	A	C	14: 52,349,685 (GRCm39)	K24N	possibly damaging	Het
Ryr3	T	A	2: 112,797,548 (GRCm39)	T122S	probably damaging	Het
Sfn	A	G	4: 133,328,636 (GRCm39)	S149P	probably benign	Het
Slc27a2	T	A	2: 126,409,736 (GRCm39)	V306D	probably damaging	Het
Slc35a1	A	G	4: 34,675,584 (GRCm39)	V81A	probably benign	Het
Trav21-dv12	A	T	14: 54,113,955 (GRCm39)	D25V	probably benign	Het
Ttn	T	C	2: 76,598,878 (GRCm39)	H11018R	possibly damaging	Het
Txn1	A	T	4: 57,950,883 (GRCm39)	Y49N	probably benign	Het
Ulk2	C	T	11: 61,672,886 (GRCm39)	A903T	probably damaging	Het
Vmn2r77	G	A	7: 86,444,360 (GRCm39)	M4I	unknown	Het
Vmn2r9	G	A	5: 108,991,502 (GRCm39)	L620F	probably damaging	Het
Vrk2	T	A	11: 26,485,638 (GRCm39)	R117*	probably null	Het
Xpo6	A	T	7: 125,712,980 (GRCm39)		probably benign	Het
Zdhhc14	C	A	17: 5,803,157 (GRCm39)	T420K	probably benign	Het
Zfp334	G	T	2: 165,228,869 (GRCm39)		probably benign	Het
Zfp958	T	A	8: 4,678,990 (GRCm39)	C338*	probably null	Het

Other mutations in Vmn2r85

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01160:Vmn2r85	APN	10	130,254,690 (GRCm39)	missense	probably benign	0.22
IGL01298:Vmn2r85	APN	10	130,254,690 (GRCm39)	missense	probably benign	0.22
IGL01361:Vmn2r85	APN	10	130,254,690 (GRCm39)	missense	probably benign	0.22
IGL02505:Vmn2r85	APN	10	130,261,449 (GRCm39)	missense	probably damaging	1.00
IGL02607:Vmn2r85	APN	10	130,262,290 (GRCm39)	missense	possibly damaging	0.89
IGL02755:Vmn2r85	APN	10	130,261,381 (GRCm39)	missense	probably damaging	0.98
IGL03188:Vmn2r85	APN	10	130,254,612 (GRCm39)	missense	probably benign	0.16
IGL03366:Vmn2r85	APN	10	130,262,328 (GRCm39)	missense	probably benign	0.00
IGL03397:Vmn2r85	APN	10	130,261,263 (GRCm39)	missense	probably damaging	1.00
PIT4445001:Vmn2r85	UTSW	10	130,261,572 (GRCm39)	missense	probably benign	0.00
R0066:Vmn2r85	UTSW	10	130,261,770 (GRCm39)	missense	probably damaging	1.00
R0128:Vmn2r85	UTSW	10	130,255,054 (GRCm39)	splice site	probably benign
R0130:Vmn2r85	UTSW	10	130,255,054 (GRCm39)	splice site	probably benign
R0503:Vmn2r85	UTSW	10	130,258,609 (GRCm39)	missense	probably damaging	1.00
R0827:Vmn2r85	UTSW	10	130,265,387 (GRCm39)	missense	possibly damaging	0.89
R1432:Vmn2r85	UTSW	10	130,261,155 (GRCm39)	missense	possibly damaging	0.74
R1521:Vmn2r85	UTSW	10	130,261,788 (GRCm39)	missense	probably damaging	0.99
R2029:Vmn2r85	UTSW	10	130,261,443 (GRCm39)	nonsense	probably null
R2034:Vmn2r85	UTSW	10	130,262,242 (GRCm39)	splice site	probably benign
R2852:Vmn2r85	UTSW	10	130,255,035 (GRCm39)	missense	probably benign	0.03
R2853:Vmn2r85	UTSW	10	130,255,035 (GRCm39)	missense	probably benign	0.03
R3084:Vmn2r85	UTSW	10	130,261,081 (GRCm39)	missense	probably benign	0.00
R3085:Vmn2r85	UTSW	10	130,261,081 (GRCm39)	missense	probably benign	0.00
R3430:Vmn2r85	UTSW	10	130,254,758 (GRCm39)	missense	probably damaging	0.97
R3694:Vmn2r85	UTSW	10	130,254,171 (GRCm39)	missense	probably damaging	0.99
R3932:Vmn2r85	UTSW	10	130,254,336 (GRCm39)	missense	probably damaging	1.00
R4207:Vmn2r85	UTSW	10	130,254,574 (GRCm39)	missense	probably damaging	1.00
R4628:Vmn2r85	UTSW	10	130,261,235 (GRCm39)	missense	probably benign	0.00
R4814:Vmn2r85	UTSW	10	130,254,567 (GRCm39)	missense	probably benign	0.12
R4948:Vmn2r85	UTSW	10	130,254,990 (GRCm39)	missense	probably damaging	1.00
R4951:Vmn2r85	UTSW	10	130,261,113 (GRCm39)	missense	probably damaging	1.00
R4959:Vmn2r85	UTSW	10	130,257,302 (GRCm39)	missense	probably damaging	1.00
R5336:Vmn2r85	UTSW	10	130,258,574 (GRCm39)	missense	possibly damaging	0.63
R5643:Vmn2r85	UTSW	10	130,262,343 (GRCm39)	missense	probably damaging	1.00
R6061:Vmn2r85	UTSW	10	130,261,531 (GRCm39)	missense	probably benign	0.09
R6115:Vmn2r85	UTSW	10	130,258,672 (GRCm39)	missense	probably damaging	1.00
R6190:Vmn2r85	UTSW	10	130,261,330 (GRCm39)	missense	possibly damaging	0.88
R6518:Vmn2r85	UTSW	10	130,265,281 (GRCm39)	missense	probably benign	0.00
R6533:Vmn2r85	UTSW	10	130,262,529 (GRCm39)	missense	probably benign	0.00
R6610:Vmn2r85	UTSW	10	130,261,838 (GRCm39)	missense	probably damaging	0.97
R6809:Vmn2r85	UTSW	10	130,261,795 (GRCm39)	missense	probably benign
R6962:Vmn2r85	UTSW	10	130,261,452 (GRCm39)	missense	probably damaging	0.99
R7075:Vmn2r85	UTSW	10	130,258,557 (GRCm39)	missense	probably benign	0.06
R7104:Vmn2r85	UTSW	10	130,262,376 (GRCm39)	missense	probably benign
R7424:Vmn2r85	UTSW	10	130,254,849 (GRCm39)	missense	probably damaging	1.00
R7516:Vmn2r85	UTSW	10	130,254,852 (GRCm39)	missense	probably damaging	1.00
R7537:Vmn2r85	UTSW	10	130,258,735 (GRCm39)	missense	probably benign	0.01
R7768:Vmn2r85	UTSW	10	130,254,562 (GRCm39)	missense	probably damaging	1.00
R7810:Vmn2r85	UTSW	10	130,261,081 (GRCm39)	missense	probably benign	0.00
R8078:Vmn2r85	UTSW	10	130,265,364 (GRCm39)	nonsense	probably null
R8115:Vmn2r85	UTSW	10	130,261,820 (GRCm39)	missense	probably benign	0.06
R8262:Vmn2r85	UTSW	10	130,254,738 (GRCm39)	missense	probably damaging	0.98
R8395:Vmn2r85	UTSW	10	130,261,797 (GRCm39)	missense	probably damaging	0.99
R8409:Vmn2r85	UTSW	10	130,261,257 (GRCm39)	missense	probably benign	0.16
R8547:Vmn2r85	UTSW	10	130,261,311 (GRCm39)	missense	probably damaging	1.00
R8875:Vmn2r85	UTSW	10	130,254,171 (GRCm39)	missense	probably damaging	0.99
R9035:Vmn2r85	UTSW	10	130,261,479 (GRCm39)	missense	probably benign
R9040:Vmn2r85	UTSW	10	130,254,311 (GRCm39)	missense	probably damaging	1.00
R9115:Vmn2r85	UTSW	10	130,254,153 (GRCm39)	missense	probably benign	0.00
R9182:Vmn2r85	UTSW	10	130,265,350 (GRCm39)	missense	probably benign	0.00
R9245:Vmn2r85	UTSW	10	130,261,534 (GRCm39)	missense	probably damaging	1.00
R9245:Vmn2r85	UTSW	10	130,255,033 (GRCm39)	missense	possibly damaging	0.92
R9405:Vmn2r85	UTSW	10	130,261,215 (GRCm39)	missense	probably damaging	0.99
R9502:Vmn2r85	UTSW	10	130,261,387 (GRCm39)	missense	probably damaging	0.99
R9520:Vmn2r85	UTSW	10	130,254,993 (GRCm39)	missense	probably benign
R9653:Vmn2r85	UTSW	10	130,261,694 (GRCm39)	missense	probably damaging	0.99
Z1176:Vmn2r85	UTSW	10	130,261,713 (GRCm39)	missense	probably damaging	0.99
Z1177:Vmn2r85	UTSW	10	130,254,776 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16