Incidental Mutation 'IGL02185:Zdhhc14'
ID283598
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zdhhc14
Ensembl Gene ENSMUSG00000034265
Gene Namezinc finger, DHHC domain containing 14
SynonymsNew1cp, B530001K09Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02185
Quality Score
Status
Chromosome17
Chromosomal Location5492557-5753811 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 5752882 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 420 (T420K)
Ref Sequence ENSEMBL: ENSMUSP00000086589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089185]
Predicted Effect probably benign
Transcript: ENSMUST00000089185
AA Change: T420K

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000086589
Gene: ENSMUSG00000034265
AA Change: T420K

DomainStartEndE-ValueType
transmembrane domain 62 81 N/A INTRINSIC
transmembrane domain 91 110 N/A INTRINSIC
Pfam:zf-DHHC 160 289 1.8e-38 PFAM
low complexity region 351 365 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110043O21Rik A T 4: 35,197,046 W340R probably damaging Het
Adh5 A G 3: 138,451,054 D167G probably benign Het
Cand2 G A 6: 115,789,510 A359T probably benign Het
Cnnm2 T C 19: 46,762,995 V408A probably benign Het
Eloa A G 4: 136,012,979 probably benign Het
Ern2 T C 7: 122,173,375 probably benign Het
Hs6st3 A G 14: 119,868,884 probably null Het
Hydin A T 8: 110,506,476 I1736F possibly damaging Het
Ifrd2 A T 9: 107,591,091 I253F probably benign Het
Kctd7 G A 5: 130,152,458 V241I possibly damaging Het
Lcp1 T C 14: 75,229,300 F616L possibly damaging Het
Lyst C T 13: 13,661,093 Q1787* probably null Het
Mapkbp1 A T 2: 120,014,663 T342S possibly damaging Het
Mcph1 A G 8: 18,668,990 probably benign Het
Mctp2 T C 7: 72,080,823 H868R probably benign Het
Mefv T C 16: 3,715,850 T186A probably benign Het
Nol9 T A 4: 152,057,911 I666N probably damaging Het
Olfr145 A C 9: 37,898,235 Y277S probably damaging Het
Olfr574 T A 7: 102,948,514 N16K probably damaging Het
Olfr775 G T 10: 129,251,035 C167F possibly damaging Het
Pum2 T C 12: 8,748,955 probably null Het
Rpgrip1 A C 14: 52,112,228 K24N possibly damaging Het
Ryr3 T A 2: 112,967,203 T122S probably damaging Het
Sfn A G 4: 133,601,325 S149P probably benign Het
Slc27a2 T A 2: 126,567,816 V306D probably damaging Het
Slc35a1 A G 4: 34,675,584 V81A probably benign Het
Trav21-dv12 A T 14: 53,876,498 D25V probably benign Het
Ttn T C 2: 76,768,534 H11018R possibly damaging Het
Txn1 A T 4: 57,950,883 Y49N probably benign Het
Ulk2 C T 11: 61,782,060 A903T probably damaging Het
Vmn2r77 G A 7: 86,795,152 M4I unknown Het
Vmn2r85 G T 10: 130,418,692 L708I probably benign Het
Vmn2r9 G A 5: 108,843,636 L620F probably damaging Het
Vrk2 T A 11: 26,535,638 R117* probably null Het
Xpo6 A T 7: 126,113,808 probably benign Het
Zfp334 G T 2: 165,386,949 probably benign Het
Zfp958 T A 8: 4,628,990 C338* probably null Het
Other mutations in Zdhhc14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00419:Zdhhc14 APN 17 5752684 splice site probably benign
IGL00909:Zdhhc14 APN 17 5752792 missense probably benign
IGL00964:Zdhhc14 APN 17 5712481 missense probably damaging 1.00
IGL01398:Zdhhc14 APN 17 5712463 missense possibly damaging 0.90
IGL01483:Zdhhc14 APN 17 5712458 missense probably benign 0.01
IGL02801:Zdhhc14 APN 17 5726819 splice site probably null
R0189:Zdhhc14 UTSW 17 5725264 missense possibly damaging 0.90
R0304:Zdhhc14 UTSW 17 5725336 splice site probably benign
R0648:Zdhhc14 UTSW 17 5493602 missense probably benign 0.01
R1017:Zdhhc14 UTSW 17 5493649 missense probably damaging 0.99
R1595:Zdhhc14 UTSW 17 5493556 missense probably benign 0.00
R2416:Zdhhc14 UTSW 17 5753008 missense probably benign
R3420:Zdhhc14 UTSW 17 5753091 makesense probably null
R3421:Zdhhc14 UTSW 17 5753091 makesense probably null
R4063:Zdhhc14 UTSW 17 5752708 missense probably damaging 1.00
R4088:Zdhhc14 UTSW 17 5726856 missense probably benign 0.01
R5359:Zdhhc14 UTSW 17 5493546 missense probably benign
R6236:Zdhhc14 UTSW 17 5493643 missense probably damaging 1.00
R7029:Zdhhc14 UTSW 17 5647911 missense probably damaging 0.97
Posted On2015-04-16