Incidental Mutation 'IGL00945:Olfr811'
ID28360
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr811
Ensembl Gene ENSMUSG00000063173
Gene Nameolfactory receptor 811
SynonymsMOR110-6, GA_x6K02T2PULF-11481207-11480248
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL00945
Quality Score
Status
Chromosome10
Chromosomal Location129800615-129804396 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 129801907 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 206 (V206E)
Ref Sequence ENSEMBL: ENSMUSP00000149970 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076437] [ENSMUST00000215058] [ENSMUST00000217571]
Predicted Effect possibly damaging
Transcript: ENSMUST00000076437
AA Change: V206E

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000075768
Gene: ENSMUSG00000063173
AA Change: V206E

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.1e-51 PFAM
Pfam:7tm_1 39 288 1.5e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215058
AA Change: V206E

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216283
Predicted Effect possibly damaging
Transcript: ENSMUST00000217571
AA Change: V206E

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim2 A G 5: 35,837,020 I101V probably damaging Het
Aldh5a1 A G 13: 24,926,158 probably benign Het
Arhgef28 A C 13: 97,967,399 L728R possibly damaging Het
Dct G A 14: 118,040,504 T218M probably damaging Het
Hcn2 C T 10: 79,733,803 R546* probably null Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Lap3 A G 5: 45,504,773 probably null Het
Mettl16 C T 11: 74,817,366 H464Y probably benign Het
Myh13 G A 11: 67,348,006 R725Q probably null Het
Nf1 T C 11: 79,469,803 F1436L probably damaging Het
Nod1 C T 6: 54,944,586 probably null Het
Pde5a T A 3: 122,835,642 probably null Het
Pja2 T C 17: 64,309,396 Y168C probably benign Het
Plod2 A G 9: 92,584,496 I170V probably benign Het
Pop5 A G 5: 115,240,559 probably benign Het
Sdk1 G T 5: 142,084,613 probably null Het
Sema3f G A 9: 107,685,522 S420L probably benign Het
Shtn1 C T 19: 59,018,952 E289K possibly damaging Het
Smarca1 A T X: 47,858,301 Y526* probably null Het
Sptan1 T C 2: 30,000,071 probably benign Het
St7l C A 3: 104,926,482 H486Q probably damaging Het
Tcte1 C A 17: 45,541,189 F449L probably benign Het
Tmem131 A G 1: 36,827,005 probably benign Het
Trim46 A G 3: 89,244,418 probably benign Het
Wwp1 A T 4: 19,640,193 probably null Het
Zc3h13 A G 14: 75,330,147 D960G probably damaging Het
Other mutations in Olfr811
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01957:Olfr811 APN 10 129802250 missense probably damaging 1.00
IGL02394:Olfr811 APN 10 129802313 missense possibly damaging 0.90
IGL02451:Olfr811 APN 10 129801833 nonsense probably null
IGL03111:Olfr811 APN 10 129802078 missense probably benign 0.00
IGL03369:Olfr811 APN 10 129802471 missense probably damaging 0.99
R0704:Olfr811 UTSW 10 129802303 missense probably benign 0.01
R1393:Olfr811 UTSW 10 129801932 missense probably benign 0.22
R1941:Olfr811 UTSW 10 129802412 missense probably benign 0.00
R1994:Olfr811 UTSW 10 129801661 missense probably damaging 1.00
R3427:Olfr811 UTSW 10 129801851 missense possibly damaging 0.85
R4296:Olfr811 UTSW 10 129802300 missense probably damaging 0.97
R4937:Olfr811 UTSW 10 129802063 missense probably benign 0.31
R5016:Olfr811 UTSW 10 129801793 missense probably benign 0.01
R5615:Olfr811 UTSW 10 129801767 missense probably damaging 1.00
R5662:Olfr811 UTSW 10 129802307 missense possibly damaging 0.83
R5750:Olfr811 UTSW 10 129801620 missense probably benign 0.01
R6109:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6109:Olfr811 UTSW 10 129801821 missense probably damaging 1.00
R6110:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6110:Olfr811 UTSW 10 129801821 missense probably damaging 1.00
R6117:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6117:Olfr811 UTSW 10 129801821 missense probably damaging 1.00
R6119:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6119:Olfr811 UTSW 10 129801821 missense probably damaging 1.00
R6120:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6120:Olfr811 UTSW 10 129801821 missense probably damaging 1.00
R6124:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6124:Olfr811 UTSW 10 129801821 missense probably damaging 1.00
R6395:Olfr811 UTSW 10 129802144 missense probably damaging 1.00
R6440:Olfr811 UTSW 10 129801968 missense probably damaging 1.00
R6559:Olfr811 UTSW 10 129801664 missense probably damaging 1.00
R6707:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6708:Olfr811 UTSW 10 129801820 missense probably damaging 1.00
R6868:Olfr811 UTSW 10 129802168 missense probably damaging 1.00
Posted On2013-04-17