Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02186:Or2f1b'

283618

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2f1b

Ensembl Gene

ENSMUSG00000095236

Gene Name

olfactory receptor family 2 subfamily F member 1B

Synonyms

18A, GA_x6K02T2P3E9-4797841-4796888, Olfr38, MOR257-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

IGL02186

Quality Score

Status

Chromosome

Chromosomal Location

42738988-42739941 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42739880 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 298 (K298R)

Ref Sequence

ENSEMBL: ENSMUSP00000093654 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074499] [ENSMUST00000215796]

AlphaFold

Q8VGP4

Predicted Effect

probably null
Transcript: ENSMUST00000074499
AA Change: K298R

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000093654
Gene: ENSMUSG00000095236
AA Change: K298R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.8e-52	PFAM
Pfam:7tm_1	41	290	5.4e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215796
AA Change: K298R

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130230L23Rik	A	G	5: 66,145,811 (GRCm39)	F100S	unknown	Het
Abca3	A	G	17: 24,596,714 (GRCm39)	Y389C	possibly damaging	Het
Acrbp	G	T	6: 125,031,773 (GRCm39)		probably null	Het
Adam21	G	A	12: 81,605,983 (GRCm39)	T593I	possibly damaging	Het
Adipor1	T	A	1: 134,353,698 (GRCm39)	M161K	probably benign	Het
Agrp	A	T	8: 106,293,821 (GRCm39)	N48K	probably benign	Het
Asprv1	A	T	6: 86,605,900 (GRCm39)	M249L	probably damaging	Het
Begain	A	G	12: 108,999,278 (GRCm39)	Y703H	probably damaging	Het
Bspry	T	A	4: 62,414,226 (GRCm39)		probably benign	Het
Cct8l1	T	G	5: 25,721,836 (GRCm39)	S184A	probably benign	Het
Cdk13	C	T	13: 17,947,112 (GRCm39)	V549I	probably benign	Het
Cdyl2	C	T	8: 117,306,025 (GRCm39)	R412Q	possibly damaging	Het
Celf6	T	C	9: 59,510,808 (GRCm39)	S205P	probably damaging	Het
Cltc	G	A	11: 86,595,811 (GRCm39)	A1263V	possibly damaging	Het
Cltc	C	A	11: 86,595,812 (GRCm39)	A1263S	possibly damaging	Het
Ctnnd2	T	A	15: 30,480,939 (GRCm39)	F62L	probably damaging	Het
Dlec1	T	A	9: 118,972,695 (GRCm39)	C1473S	probably benign	Het
Dmbt1	T	A	7: 130,694,986 (GRCm39)		probably benign	Het
Dnase1	G	A	16: 3,856,896 (GRCm39)	V176I	probably benign	Het
Dusp1	G	T	17: 26,726,032 (GRCm39)	Y220*	probably null	Het
Enpp3	A	C	10: 24,667,881 (GRCm39)		probably benign	Het
Exosc10	T	C	4: 148,649,755 (GRCm39)	L395P	probably damaging	Het
Fn1	T	C	1: 71,677,693 (GRCm39)	K533R	probably damaging	Het
Gcm2	T	A	13: 41,258,125 (GRCm39)	T168S	possibly damaging	Het
Gm9924	C	A	5: 31,252,491 (GRCm39)		probably benign	Het
Ifrd1	A	G	12: 40,264,092 (GRCm39)	V101A	probably benign	Het
Iqsec1	G	T	6: 90,653,859 (GRCm39)	Q629K	probably damaging	Het
Kcnma1	T	A	14: 23,576,881 (GRCm39)	M254L	probably benign	Het
Krit1	T	C	5: 3,859,733 (GRCm39)		probably benign	Het
Letm1	T	C	5: 33,902,391 (GRCm39)	K633E	probably benign	Het
Mfsd1	A	G	3: 67,503,928 (GRCm39)	I307V	probably benign	Het
Mtrr	T	C	13: 68,712,476 (GRCm39)	T637A	probably benign	Het
Naxe	C	A	3: 87,964,305 (GRCm39)	D212Y	probably damaging	Het
Nlk	A	T	11: 78,477,762 (GRCm39)	V327D	probably damaging	Het
Or5w11	A	T	2: 87,459,715 (GRCm39)	I187F	probably benign	Het
Pdzd8	C	T	19: 59,289,060 (GRCm39)	G780D	probably damaging	Het
Prune1	T	C	3: 95,166,548 (GRCm39)		probably benign	Het
Qser1	A	T	2: 104,618,606 (GRCm39)	H645Q	probably damaging	Het
Rd3l	A	G	12: 111,945,901 (GRCm39)	Y193H	probably benign	Het
Reln	A	G	5: 22,114,956 (GRCm39)	Y3119H	probably damaging	Het
Scel	C	T	14: 103,802,257 (GRCm39)	A219V	probably benign	Het
Skint11	A	T	4: 114,101,833 (GRCm39)	Q91L	possibly damaging	Het
Slc39a10	G	A	1: 46,857,288 (GRCm39)	A696V	probably damaging	Het
Slc5a5	C	A	8: 71,338,764 (GRCm39)	D516Y	possibly damaging	Het
Slc8b1	G	A	5: 120,665,928 (GRCm39)		probably null	Het
Slc9a3	A	G	13: 74,311,233 (GRCm39)	E576G	possibly damaging	Het
Slco1b2	A	T	6: 141,580,271 (GRCm39)		probably benign	Het
Smc5	A	G	19: 23,209,223 (GRCm39)	V647A	probably damaging	Het
Snph	T	C	2: 151,436,263 (GRCm39)	N222D	possibly damaging	Het
Srbd1	A	G	17: 86,416,659 (GRCm39)	F500L	probably benign	Het
Stxbp6	T	C	12: 44,948,806 (GRCm39)	D101G	probably damaging	Het
Taar7b	A	G	10: 23,875,879 (GRCm39)	I15V	probably benign	Het
Tdrd12	G	T	7: 35,200,826 (GRCm39)	N338K	probably damaging	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Tmem219	A	T	7: 126,495,988 (GRCm39)	D128E	probably benign	Het
Togaram2	A	G	17: 71,992,166 (GRCm39)	T3A	possibly damaging	Het
Ttn	C	T	2: 76,724,627 (GRCm39)		probably benign	Het
Uchl1	C	A	5: 66,834,382 (GRCm39)	C47*	probably null	Het
Unc79	T	G	12: 102,977,542 (GRCm39)	S182A	probably benign	Het
Vmn2r1	A	G	3: 63,989,138 (GRCm39)	T26A	probably benign	Het
Vmn2r9	G	A	5: 108,991,502 (GRCm39)	L620F	probably damaging	Het
Vps54	T	C	11: 21,256,947 (GRCm39)	V685A	probably damaging	Het
Zcchc7	T	G	4: 44,762,250 (GRCm39)	V126G	possibly damaging	Het
Zmym2	A	G	14: 57,180,808 (GRCm39)	T907A	probably benign	Het

Other mutations in Or2f1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01551:Or2f1b	APN	6	42,739,046 (GRCm39)	missense	probably damaging	0.99
IGL01567:Or2f1b	APN	6	42,739,661 (GRCm39)	missense	probably benign	0.07
IGL02097:Or2f1b	APN	6	42,739,394 (GRCm39)	missense	probably damaging	0.98
IGL02473:Or2f1b	APN	6	42,739,640 (GRCm39)	missense	probably damaging	1.00
R0541:Or2f1b	UTSW	6	42,739,154 (GRCm39)	missense	probably damaging	1.00
R1210:Or2f1b	UTSW	6	42,739,601 (GRCm39)	missense	possibly damaging	0.79
R1368:Or2f1b	UTSW	6	42,739,613 (GRCm39)	missense	possibly damaging	0.91
R2383:Or2f1b	UTSW	6	42,739,393 (GRCm39)	missense	probably benign	0.44
R4614:Or2f1b	UTSW	6	42,739,352 (GRCm39)	missense	probably benign	0.07
R4616:Or2f1b	UTSW	6	42,739,352 (GRCm39)	missense	probably benign	0.07
R4844:Or2f1b	UTSW	6	42,739,394 (GRCm39)	missense	probably damaging	0.98
R5121:Or2f1b	UTSW	6	42,739,931 (GRCm39)	nonsense	probably null
R5951:Or2f1b	UTSW	6	42,739,493 (GRCm39)	missense	probably damaging	1.00
R6061:Or2f1b	UTSW	6	42,739,899 (GRCm39)	missense	probably damaging	0.99
R6336:Or2f1b	UTSW	6	42,739,591 (GRCm39)	missense	probably damaging	1.00
R7414:Or2f1b	UTSW	6	42,739,762 (GRCm39)	missense	probably damaging	1.00
R8344:Or2f1b	UTSW	6	42,739,499 (GRCm39)	missense	probably benign	0.03
R9603:Or2f1b	UTSW	6	42,739,672 (GRCm39)	nonsense	probably null
X0018:Or2f1b	UTSW	6	42,739,869 (GRCm39)	missense	probably damaging	0.99
Z1177:Or2f1b	UTSW	6	42,739,141 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16