Incidental Mutation 'IGL02188:Or5b113'
| ID |
283730 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or5b113
|
| Ensembl Gene |
ENSMUSG00000049015 |
| Gene Name |
olfactory receptor family 5 subfamily B member 113 |
| Synonyms |
GA_x6K02T2RE5P-3695694-3696620, Olfr1467, MOR202-15 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.091)
|
| Stock # |
IGL02188
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
13341994-13342920 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 13342396 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 135
(M135L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149487
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054687]
[ENSMUST00000215096]
|
| AlphaFold |
Q8VFW1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054687
AA Change: M135L
PolyPhen 2
Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000061580
Gene: ENSMUSG00000049015
AA Change: M135L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
30 |
307 |
6.6e-48 |
PFAM |
|
Pfam:7tm_1
|
40 |
289 |
7.4e-20 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000215096
AA Change: M135L
PolyPhen 2
Score 0.391 (Sensitivity: 0.90; Specificity: 0.89)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afap1 |
A |
G |
5: 36,093,421 (GRCm39) |
N56S |
probably benign |
Het |
| Asb18 |
A |
G |
1: 89,924,021 (GRCm39) |
C81R |
probably benign |
Het |
| Ccl25 |
A |
C |
8: 4,398,552 (GRCm39) |
|
probably benign |
Het |
| Cdh13 |
A |
G |
8: 119,578,500 (GRCm39) |
T176A |
probably benign |
Het |
| Cnrip1 |
A |
G |
11: 17,028,398 (GRCm39) |
|
probably null |
Het |
| Dnmt1 |
A |
T |
9: 20,853,034 (GRCm39) |
C62* |
probably null |
Het |
| Eepd1 |
T |
C |
9: 25,493,188 (GRCm39) |
F311L |
probably benign |
Het |
| Extl3 |
A |
G |
14: 65,313,154 (GRCm39) |
L676P |
probably damaging |
Het |
| F13a1 |
A |
G |
13: 37,090,035 (GRCm39) |
|
probably benign |
Het |
| Galnt12 |
C |
T |
4: 47,122,521 (GRCm39) |
R267W |
probably damaging |
Het |
| Gm5150 |
T |
A |
3: 16,017,826 (GRCm39) |
K148N |
possibly damaging |
Het |
| Haus8 |
G |
T |
8: 71,710,059 (GRCm39) |
A51E |
probably damaging |
Het |
| Hyal5 |
T |
C |
6: 24,877,035 (GRCm39) |
Y303H |
probably damaging |
Het |
| Itga5 |
C |
T |
15: 103,256,144 (GRCm39) |
R936H |
probably benign |
Het |
| Itgb4 |
A |
G |
11: 115,894,213 (GRCm39) |
N1282S |
probably benign |
Het |
| Krt26 |
C |
T |
11: 99,224,471 (GRCm39) |
R349Q |
probably benign |
Het |
| Matn4 |
C |
T |
2: 164,242,786 (GRCm39) |
R104H |
probably benign |
Het |
| Mideas |
T |
C |
12: 84,209,100 (GRCm39) |
I667M |
probably benign |
Het |
| Myg1 |
T |
C |
15: 102,245,876 (GRCm39) |
I238T |
probably benign |
Het |
| Myo7a |
C |
T |
7: 97,740,234 (GRCm39) |
A598T |
probably damaging |
Het |
| Nbea |
T |
A |
3: 55,891,258 (GRCm39) |
I1604L |
probably benign |
Het |
| Nfx1 |
G |
A |
4: 40,993,827 (GRCm39) |
G547R |
probably damaging |
Het |
| Pelp1 |
T |
A |
11: 70,300,718 (GRCm39) |
I41F |
unknown |
Het |
| Pla2g2f |
T |
C |
4: 138,479,518 (GRCm39) |
|
probably benign |
Het |
| Rab19 |
T |
A |
6: 39,360,968 (GRCm39) |
S39T |
probably benign |
Het |
| Samd8 |
T |
C |
14: 21,833,866 (GRCm39) |
|
probably null |
Het |
| Sec16a |
T |
C |
2: 26,326,020 (GRCm39) |
D1219G |
probably damaging |
Het |
| Slc2a4 |
C |
T |
11: 69,837,156 (GRCm39) |
M1I |
probably null |
Het |
| Slc44a1 |
T |
C |
4: 53,541,361 (GRCm39) |
V273A |
probably benign |
Het |
| Spata31f1e |
T |
A |
4: 42,791,994 (GRCm39) |
|
probably null |
Het |
| Svep1 |
T |
C |
4: 58,068,382 (GRCm39) |
T3135A |
possibly damaging |
Het |
| Tnnc1 |
T |
C |
14: 30,932,617 (GRCm39) |
L100P |
possibly damaging |
Het |
| Ubr3 |
C |
T |
2: 69,789,955 (GRCm39) |
R870* |
probably null |
Het |
| Usp28 |
T |
C |
9: 48,935,309 (GRCm39) |
S87P |
probably benign |
Het |
| Xylt1 |
T |
A |
7: 117,233,964 (GRCm39) |
V497E |
probably damaging |
Het |
| Zfp318 |
C |
T |
17: 46,707,736 (GRCm39) |
R265* |
probably null |
Het |
|
| Other mutations in Or5b113 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00936:Or5b113
|
APN |
19 |
13,341,988 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL01109:Or5b113
|
APN |
19 |
13,342,063 (GRCm39) |
missense |
probably benign |
|
|
IGL01939:Or5b113
|
APN |
19 |
13,342,807 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02188:Or5b113
|
APN |
19 |
13,342,643 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03223:Or5b113
|
APN |
19 |
13,342,645 (GRCm39) |
missense |
probably benign |
|
|
R0456:Or5b113
|
UTSW |
19 |
13,342,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1066:Or5b113
|
UTSW |
19 |
13,342,451 (GRCm39) |
missense |
probably benign |
|
|
R1189:Or5b113
|
UTSW |
19 |
13,342,543 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1668:Or5b113
|
UTSW |
19 |
13,342,234 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1754:Or5b113
|
UTSW |
19 |
13,342,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1860:Or5b113
|
UTSW |
19 |
13,342,705 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1861:Or5b113
|
UTSW |
19 |
13,342,705 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2181:Or5b113
|
UTSW |
19 |
13,342,438 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2219:Or5b113
|
UTSW |
19 |
13,342,901 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2516:Or5b113
|
UTSW |
19 |
13,342,557 (GRCm39) |
nonsense |
probably null |
|
|
R4757:Or5b113
|
UTSW |
19 |
13,342,810 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5206:Or5b113
|
UTSW |
19 |
13,342,429 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5376:Or5b113
|
UTSW |
19 |
13,342,762 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5647:Or5b113
|
UTSW |
19 |
13,342,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Or5b113
|
UTSW |
19 |
13,342,515 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5741:Or5b113
|
UTSW |
19 |
13,342,847 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5906:Or5b113
|
UTSW |
19 |
13,342,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6636:Or5b113
|
UTSW |
19 |
13,342,589 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6637:Or5b113
|
UTSW |
19 |
13,342,589 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7000:Or5b113
|
UTSW |
19 |
13,341,987 (GRCm39) |
start gained |
probably benign |
|
|
R7254:Or5b113
|
UTSW |
19 |
13,342,475 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7325:Or5b113
|
UTSW |
19 |
13,342,001 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7773:Or5b113
|
UTSW |
19 |
13,342,598 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7828:Or5b113
|
UTSW |
19 |
13,342,510 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9081:Or5b113
|
UTSW |
19 |
13,342,019 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9135:Or5b113
|
UTSW |
19 |
13,342,755 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9151:Or5b113
|
UTSW |
19 |
13,342,222 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9470:Or5b113
|
UTSW |
19 |
13,342,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9792:Or5b113
|
UTSW |
19 |
13,342,514 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9793:Or5b113
|
UTSW |
19 |
13,342,514 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Or5b113
|
UTSW |
19 |
13,342,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Or5b113
|
UTSW |
19 |
13,342,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation