Incidental Mutation 'IGL02188:Rab19'
ID283743
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rab19
Ensembl Gene ENSMUSG00000029923
Gene NameRAB19, member RAS oncogene family
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.266) question?
Stock #IGL02188
Quality Score
Status
Chromosome6
Chromosomal Location39381175-39390380 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 39384034 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 39 (S39T)
Ref Sequence ENSEMBL: ENSMUSP00000031986 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031986]
Predicted Effect probably benign
Transcript: ENSMUST00000031986
AA Change: S39T

PolyPhen 2 Score 0.105 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000031986
Gene: ENSMUSG00000029923
AA Change: S39T

DomainStartEndE-ValueType
RAB 18 182 3.39e-99 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1 A G 5: 35,936,077 N56S probably benign Het
Asb18 A G 1: 89,996,299 C81R probably benign Het
Ccl25 A C 8: 4,348,552 probably benign Het
Cdh13 A G 8: 118,851,761 T176A probably benign Het
Cnrip1 A G 11: 17,078,398 probably null Het
Dnmt1 A T 9: 20,941,738 C62* probably null Het
Eepd1 T C 9: 25,581,892 F311L probably benign Het
Elmsan1 T C 12: 84,162,326 I667M probably benign Het
Extl3 A G 14: 65,075,705 L676P probably damaging Het
F13a1 A G 13: 36,906,061 probably benign Het
Galnt12 C T 4: 47,122,521 R267W probably damaging Het
Gm12394 T A 4: 42,791,994 probably null Het
Gm5150 T A 3: 15,963,662 K148N possibly damaging Het
Haus8 G T 8: 71,257,415 A51E probably damaging Het
Hyal5 T C 6: 24,877,036 Y303H probably damaging Het
Itga5 C T 15: 103,347,717 R936H probably benign Het
Itgb4 A G 11: 116,003,387 N1282S probably benign Het
Krt26 C T 11: 99,333,645 R349Q probably benign Het
Matn4 C T 2: 164,400,866 R104H probably benign Het
Myg1 T C 15: 102,337,441 I238T probably benign Het
Myo7a C T 7: 98,091,027 A598T probably damaging Het
Nbea T A 3: 55,983,837 I1604L probably benign Het
Nfx1 G A 4: 40,993,827 G547R probably damaging Het
Olfr1467 A T 19: 13,365,032 M135L probably benign Het
Olfr1467 A T 19: 13,365,279 Y217F probably damaging Het
Pelp1 T A 11: 70,409,892 I41F unknown Het
Pla2g2f T C 4: 138,752,207 probably benign Het
Samd8 T C 14: 21,783,798 probably null Het
Sec16a T C 2: 26,436,008 D1219G probably damaging Het
Slc2a4 C T 11: 69,946,330 M1I probably null Het
Slc44a1 T C 4: 53,541,361 V273A probably benign Het
Svep1 T C 4: 58,068,382 T3135A possibly damaging Het
Tnnc1 T C 14: 31,210,660 L100P possibly damaging Het
Ubr3 C T 2: 69,959,611 R870* probably null Het
Usp28 T C 9: 49,024,009 S87P probably benign Het
Xylt1 T A 7: 117,634,737 V497E probably damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Other mutations in Rab19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Rab19 APN 6 39388198 splice site probably benign
IGL02452:Rab19 APN 6 39389798 missense probably benign
IGL03027:Rab19 APN 6 39383993 missense probably damaging 1.00
R0009:Rab19 UTSW 6 39389687 missense probably damaging 1.00
R0312:Rab19 UTSW 6 39384089 missense probably benign 0.02
R0726:Rab19 UTSW 6 39383959 missense probably benign 0.00
R1727:Rab19 UTSW 6 39388161 nonsense probably null
R1954:Rab19 UTSW 6 39384082 missense probably benign 0.06
R2169:Rab19 UTSW 6 39384041 missense possibly damaging 0.49
R3796:Rab19 UTSW 6 39384041 missense probably benign 0.01
R4465:Rab19 UTSW 6 39388126 missense probably damaging 1.00
R5977:Rab19 UTSW 6 39383926 missense probably benign 0.07
R6619:Rab19 UTSW 6 39388126 missense probably damaging 0.99
Posted On2015-04-16