Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02189:Ttc27'

283782

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttc27

Ensembl Gene

ENSMUSG00000024078

Gene Name

tetratricopeptide repeat domain 27

Synonyms

2610511O17Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.957) question?

Stock #

IGL02189

Quality Score

Status

Chromosome

Chromosomal Location

75024730-75170565 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 75036894 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 189 (T189M)

Ref Sequence

ENSEMBL: ENSMUSP00000024882 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024882]

AlphaFold

Q8CD92

Predicted Effect

probably damaging
Transcript: ENSMUST00000024882
AA Change: T189M

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000024882
Gene: ENSMUSG00000024078
AA Change: T189M

Domain	Start	End	E-Value	Type
TPR	531	564	7.34e-3	SMART
TPR	565	598	5.56e-3	SMART
TPR	599	632	3.81e-1	SMART
Blast:TPR	633	666	7e-15	BLAST
coiled coil region	817	847	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930111J21Rik1	A	T	11: 48,838,248 (GRCm39)	Y780N	probably benign	Het
Aadacl2	T	C	3: 59,932,609 (GRCm39)	S375P	probably damaging	Het
Abi1	A	C	2: 22,930,076 (GRCm39)	M1R	probably null	Het
Acss1	T	C	2: 150,471,788 (GRCm39)	D322G	probably damaging	Het
Adam22	G	A	5: 8,380,029 (GRCm39)	R90W	possibly damaging	Het
Agtpbp1	T	C	13: 59,648,275 (GRCm39)	H515R	probably benign	Het
C3	T	C	17: 57,527,113 (GRCm39)	K779E	probably benign	Het
Cfhr2	A	G	1: 139,749,497 (GRCm39)	Y162H	probably damaging	Het
Chchd5	T	C	2: 128,975,188 (GRCm39)		probably benign	Het
Csmd1	T	A	8: 16,321,620 (GRCm39)	I493F	probably damaging	Het
Daam1	A	T	12: 71,993,059 (GRCm39)	R349S	unknown	Het
Dnah11	T	C	12: 118,046,314 (GRCm39)	E1708G	probably benign	Het
Epg5	A	G	18: 78,056,085 (GRCm39)	D1753G	probably damaging	Het
Flt4	T	G	11: 49,516,830 (GRCm39)	C206G	probably damaging	Het
Fscn1	G	T	5: 142,946,375 (GRCm39)	A58S	possibly damaging	Het
Gapvd1	A	T	2: 34,618,556 (GRCm39)	N272K	probably damaging	Het
Gem	T	A	4: 11,706,121 (GRCm39)	S70T	possibly damaging	Het
H2-K2	A	G	17: 34,218,466 (GRCm39)	L150P	probably damaging	Het
Hsd3b3	T	A	3: 98,649,454 (GRCm39)	I290L	probably benign	Het
Iws1	A	G	18: 32,226,178 (GRCm39)	R689G	probably damaging	Het
Klk1b22	A	G	7: 43,765,630 (GRCm39)		probably null	Het
Klra4	T	A	6: 130,021,105 (GRCm39)	D230V	possibly damaging	Het
Krt26	C	T	11: 99,224,471 (GRCm39)	R349Q	probably benign	Het
Liat1	A	G	11: 75,891,056 (GRCm39)	K57E	probably damaging	Het
Lilra5	A	T	7: 4,240,968 (GRCm39)	M21L	probably benign	Het
Lrrc20	T	A	10: 61,362,887 (GRCm39)	V44D	possibly damaging	Het
Mtx1	T	G	3: 89,116,624 (GRCm39)	M426L	probably damaging	Het
Mylk2	C	T	2: 152,757,074 (GRCm39)	P283L	probably damaging	Het
Mynn	T	A	3: 30,667,693 (GRCm39)		probably benign	Het
Odr4	G	T	1: 150,247,784 (GRCm39)	N356K	possibly damaging	Het
Or4c1	A	C	2: 89,133,641 (GRCm39)	C98W	probably damaging	Het
Parl	T	A	16: 20,116,453 (GRCm39)	I116F	probably damaging	Het
Pdlim3	T	C	8: 46,338,630 (GRCm39)	V5A	probably damaging	Het
Pld1	G	A	3: 28,174,932 (GRCm39)	V857I	probably benign	Het
Ptprf	T	A	4: 118,070,839 (GRCm39)		probably benign	Het
Ptprn	A	G	1: 75,235,139 (GRCm39)	S170P	possibly damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rps27a	C	A	11: 29,496,772 (GRCm39)	Q40H	probably damaging	Het
Ryr3	A	T	2: 112,585,183 (GRCm39)		probably benign	Het
Scube3	G	T	17: 28,381,970 (GRCm39)	C332F	probably benign	Het
Sh3glb2	T	C	2: 30,235,351 (GRCm39)		probably null	Het
Sh3tc2	A	G	18: 62,123,693 (GRCm39)	E818G	probably benign	Het
Slc16a3	G	A	11: 120,847,597 (GRCm39)	V262I	probably benign	Het
Sptbn1	T	A	11: 30,067,871 (GRCm39)	D1781V	probably damaging	Het
Ssr1	C	T	13: 38,171,492 (GRCm39)		probably null	Het
Tep1	A	G	14: 51,064,283 (GRCm39)	L2442S	probably benign	Het
Tonsl	A	T	15: 76,507,378 (GRCm39)	V94D	possibly damaging	Het
Ttc22	A	T	4: 106,496,354 (GRCm39)	H468L	probably benign	Het
Ttn	T	C	2: 76,720,500 (GRCm39)		probably benign	Het
Ttn	T	G	2: 76,590,239 (GRCm39)	I21157L	probably damaging	Het
Vav3	T	A	3: 109,433,276 (GRCm39)		probably benign	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het

Other mutations in Ttc27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00422:Ttc27	APN	17	75,087,811 (GRCm39)	missense	probably damaging	1.00
IGL01508:Ttc27	APN	17	75,142,352 (GRCm39)	missense	probably damaging	0.98
IGL02010:Ttc27	APN	17	75,087,906 (GRCm39)	splice site	probably benign
IGL02487:Ttc27	APN	17	75,163,549 (GRCm39)	missense	probably damaging	1.00
IGL02745:Ttc27	APN	17	75,046,728 (GRCm39)	missense	probably benign	0.37
IGL02816:Ttc27	APN	17	75,054,769 (GRCm39)	splice site	probably benign
IGL03389:Ttc27	APN	17	75,165,028 (GRCm39)	missense	probably benign	0.00
R0024:Ttc27	UTSW	17	75,077,259 (GRCm39)	missense	possibly damaging	0.79
R0511:Ttc27	UTSW	17	75,025,710 (GRCm39)	missense	probably benign	0.22
R0518:Ttc27	UTSW	17	75,163,544 (GRCm39)	missense	possibly damaging	0.80
R0521:Ttc27	UTSW	17	75,163,544 (GRCm39)	missense	possibly damaging	0.80
R0633:Ttc27	UTSW	17	75,036,972 (GRCm39)	missense	probably benign	0.02
R1415:Ttc27	UTSW	17	75,046,667 (GRCm39)	missense	probably benign
R1597:Ttc27	UTSW	17	75,170,402 (GRCm39)	missense	possibly damaging	0.95
R1961:Ttc27	UTSW	17	75,087,851 (GRCm39)	missense	probably damaging	0.99
R2038:Ttc27	UTSW	17	75,163,497 (GRCm39)	missense	probably benign	0.00
R3012:Ttc27	UTSW	17	75,147,454 (GRCm39)	missense	probably benign	0.17
R3619:Ttc27	UTSW	17	75,058,123 (GRCm39)	splice site	probably null
R4155:Ttc27	UTSW	17	75,147,455 (GRCm39)	missense	probably benign	0.09
R4272:Ttc27	UTSW	17	75,147,355 (GRCm39)	missense	probably damaging	1.00
R4291:Ttc27	UTSW	17	75,163,474 (GRCm39)	missense	probably damaging	1.00
R4557:Ttc27	UTSW	17	75,136,544 (GRCm39)	missense	probably benign	0.00
R5068:Ttc27	UTSW	17	75,106,337 (GRCm39)	missense	probably damaging	1.00
R5069:Ttc27	UTSW	17	75,106,337 (GRCm39)	missense	probably damaging	1.00
R5070:Ttc27	UTSW	17	75,106,337 (GRCm39)	missense	probably damaging	1.00
R5074:Ttc27	UTSW	17	75,054,750 (GRCm39)	missense	probably damaging	1.00
R5169:Ttc27	UTSW	17	75,054,690 (GRCm39)	nonsense	probably null
R5203:Ttc27	UTSW	17	75,084,649 (GRCm39)	missense	probably damaging	1.00
R5272:Ttc27	UTSW	17	75,049,972 (GRCm39)	missense	probably damaging	1.00
R6260:Ttc27	UTSW	17	75,165,086 (GRCm39)	missense	probably damaging	0.99
R6797:Ttc27	UTSW	17	75,036,883 (GRCm39)	missense	probably benign	0.28
R6830:Ttc27	UTSW	17	75,163,550 (GRCm39)	nonsense	probably null
R6987:Ttc27	UTSW	17	75,084,736 (GRCm39)	critical splice donor site	probably null
R7121:Ttc27	UTSW	17	75,054,710 (GRCm39)	missense	probably benign	0.04
R7393:Ttc27	UTSW	17	75,077,259 (GRCm39)	missense	possibly damaging	0.79
R7543:Ttc27	UTSW	17	75,024,745 (GRCm39)	start gained	probably benign
R7635:Ttc27	UTSW	17	75,025,710 (GRCm39)	missense	probably benign	0.22
R8231:Ttc27	UTSW	17	75,024,959 (GRCm39)	missense	probably benign	0.19
R8365:Ttc27	UTSW	17	75,054,669 (GRCm39)	missense	probably damaging	1.00
R8464:Ttc27	UTSW	17	75,024,925 (GRCm39)	missense	probably benign
R8493:Ttc27	UTSW	17	75,050,047 (GRCm39)	critical splice donor site	probably null
R8687:Ttc27	UTSW	17	75,046,679 (GRCm39)	missense	probably benign	0.00
X0026:Ttc27	UTSW	17	75,163,432 (GRCm39)	missense	probably benign	0.19

Posted On

2015-04-16