Incidental Mutation 'IGL02191:Wdr93'
ID283868
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr93
Ensembl Gene ENSMUSG00000039099
Gene NameWD repeat domain 93
SynonymsEG626359
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL02191
Quality Score
Status
Chromosome7
Chromosomal Location79743163-79785950 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 79749220 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Arginine at position 34 (K34R)
Ref Sequence ENSEMBL: ENSMUSP00000037467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035622]
Predicted Effect probably damaging
Transcript: ENSMUST00000035622
AA Change: K34R

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000037467
Gene: ENSMUSG00000039099
AA Change: K34R

DomainStartEndE-ValueType
low complexity region 240 251 N/A INTRINSIC
low complexity region 265 274 N/A INTRINSIC
SCOP:d1jofa_ 389 607 7e-4 SMART
Blast:WD40 413 451 2e-11 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 T C 12: 80,174,109 I642V probably benign Het
Adam5 G A 8: 24,812,423 R185* probably null Het
C2 T C 17: 34,866,563 I122V probably damaging Het
Camsap1 A G 2: 25,929,880 I1531T probably damaging Het
Celsr1 T C 15: 85,979,004 T1276A possibly damaging Het
Cnot7 A T 8: 40,510,027 N35K probably benign Het
Cyp2a12 A G 7: 27,036,611 I482V probably benign Het
Cyp3a57 A G 5: 145,365,685 E97G probably damaging Het
Cyp51 C A 5: 4,100,147 R192I probably benign Het
Ddx59 T C 1: 136,417,158 L189P probably damaging Het
Dnah6 A G 6: 73,017,797 I4127T probably benign Het
Dock3 C T 9: 106,938,141 V1217I probably benign Het
Ergic2 T C 6: 148,204,821 D57G probably null Het
Flvcr2 A T 12: 85,786,192 K329* probably null Het
Foxp1 T C 6: 98,945,600 S327G probably damaging Het
Gen1 A C 12: 11,242,296 H562Q probably benign Het
Gjc2 A G 11: 59,177,560 V32A probably damaging Het
Grk4 C T 5: 34,755,189 H574Y probably benign Het
Kif15 T A 9: 122,975,679 C93S probably damaging Het
Lrtm1 A C 14: 29,021,949 I125L probably benign Het
Mrgprb8 A G 7: 48,388,779 Y66C probably damaging Het
Pfn1 G A 11: 70,654,383 A33V probably damaging Het
Scnn1b A C 7: 121,917,513 K492Q probably damaging Het
Slc22a29 G A 19: 8,218,681 probably benign Het
Spocd1 A G 4: 129,953,587 D523G probably damaging Het
Tmem144 A T 3: 79,826,852 D181E possibly damaging Het
Tmem220 G A 11: 67,031,107 C101Y probably damaging Het
Tmpo A G 10: 91,161,879 V682A probably benign Het
Zdhhc16 C A 19: 41,937,691 C8* probably null Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Other mutations in Wdr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00928:Wdr93 APN 7 79775553 missense probably damaging 1.00
IGL01910:Wdr93 APN 7 79771573 missense probably damaging 1.00
IGL01977:Wdr93 APN 7 79752505 missense probably damaging 1.00
IGL01979:Wdr93 APN 7 79776652 missense probably benign 0.03
R0008:Wdr93 UTSW 7 79758473 missense probably damaging 1.00
R0008:Wdr93 UTSW 7 79758473 missense probably damaging 1.00
R1136:Wdr93 UTSW 7 79773448 missense probably damaging 1.00
R1168:Wdr93 UTSW 7 79749174 missense probably damaging 0.99
R1586:Wdr93 UTSW 7 79768361 missense probably damaging 0.99
R1605:Wdr93 UTSW 7 79771509 splice site probably null
R1651:Wdr93 UTSW 7 79750082 missense probably benign 0.00
R3078:Wdr93 UTSW 7 79752493 missense possibly damaging 0.81
R3689:Wdr93 UTSW 7 79771585 missense possibly damaging 0.91
R4013:Wdr93 UTSW 7 79768411 missense possibly damaging 0.90
R4771:Wdr93 UTSW 7 79776763 missense probably damaging 0.99
R4824:Wdr93 UTSW 7 79750069 nonsense probably null
R4887:Wdr93 UTSW 7 79785774 missense probably damaging 1.00
R5172:Wdr93 UTSW 7 79752493 missense probably damaging 0.97
R5510:Wdr93 UTSW 7 79750031 missense probably damaging 1.00
R5625:Wdr93 UTSW 7 79771018 missense probably benign 0.00
R5648:Wdr93 UTSW 7 79777226 missense probably benign 0.04
R5950:Wdr93 UTSW 7 79773431 missense probably damaging 0.99
R6147:Wdr93 UTSW 7 79758497 missense probably benign
R6530:Wdr93 UTSW 7 79755993 missense probably damaging 1.00
R7056:Wdr93 UTSW 7 79749340 missense probably damaging 1.00
R7079:Wdr93 UTSW 7 79749292 missense probably damaging 1.00
R7309:Wdr93 UTSW 7 79773355 missense possibly damaging 0.86
R7397:Wdr93 UTSW 7 79766424 missense probably null 0.01
Posted On2015-04-16