Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02184:Eif1ad15'

284244

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Eif1ad15

Ensembl Gene

ENSMUSG00000093847

Gene Name

eukaryotic translation initiation factor 1A domain containing 15

Synonyms

Gm5039

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.411) question?

Stock #

IGL02184

Quality Score

Status

Chromosome

Chromosomal Location

88286892-88288532 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88287951 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 101 (R101G)

Ref Sequence

ENSEMBL: ENSMUSP00000151971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000177747] [ENSMUST00000218054]

AlphaFold

J3QNT6

Predicted Effect

probably benign
Transcript: ENSMUST00000177747
AA Change: R101G

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000136949
Gene: ENSMUSG00000093847
AA Change: R101G

Domain	Start	End	E-Value	Type
low complexity region	3	25	N/A	INTRINSIC
eIF1a	28	110	4.9e-47	SMART
low complexity region	125	144	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000218054
AA Change: R101G

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222722

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam15	C	T	3: 89,253,241 (GRCm39)		probably benign	Het
Antxr2	A	C	5: 98,125,454 (GRCm39)		probably null	Het
Aopep	T	G	13: 63,215,925 (GRCm39)	I399S	possibly damaging	Het
Atp8b3	A	C	10: 80,363,067 (GRCm39)		probably benign	Het
Brwd1	A	T	16: 95,815,029 (GRCm39)	M1417K	probably damaging	Het
Camk2d	A	T	3: 126,591,422 (GRCm39)	R297S	probably damaging	Het
Cntnap1	A	T	11: 101,069,191 (GRCm39)	H215L	probably damaging	Het
Cytip	T	C	2: 58,023,750 (GRCm39)	S357G	probably damaging	Het
Fancg	A	G	4: 43,006,872 (GRCm39)	Y273H	possibly damaging	Het
Fbxo36	A	G	1: 84,858,885 (GRCm39)	S57G	probably benign	Het
Fgf8	A	T	19: 45,725,655 (GRCm39)	L141Q	probably damaging	Het
Grm5	C	T	7: 87,675,650 (GRCm39)	T388M	probably damaging	Het
Hipk1	A	G	3: 103,666,066 (GRCm39)	L589P	possibly damaging	Het
Kiz	T	C	2: 146,731,520 (GRCm39)	S337P	probably benign	Het
Lrrc37a	A	T	11: 103,388,435 (GRCm39)	I2330K	unknown	Het
Mdfic	T	A	6: 15,770,366 (GRCm39)	I124K	possibly damaging	Het
Mdfic2	T	C	6: 98,225,059 (GRCm39)	S75G	possibly damaging	Het
Mttp	A	G	3: 137,821,761 (GRCm39)		probably null	Het
Myom1	G	A	17: 71,379,132 (GRCm39)	S632N	possibly damaging	Het
Nlrp12	T	C	7: 3,289,094 (GRCm39)	K473E	probably damaging	Het
Nrp2	C	A	1: 62,758,099 (GRCm39)	C28*	probably null	Het
Nwd2	G	T	5: 63,963,020 (GRCm39)	G868V	probably damaging	Het
Or4a73	G	A	2: 89,420,637 (GRCm39)	T274I	probably damaging	Het
Or4c58	G	A	2: 89,674,729 (GRCm39)	A196V	probably damaging	Het
Or5w1	A	G	2: 87,487,136 (GRCm39)	L43P	probably damaging	Het
Pappa	A	T	4: 65,258,928 (GRCm39)	M1559L	possibly damaging	Het
Pmm2	T	A	16: 8,455,668 (GRCm39)	D10E	possibly damaging	Het
Polm	T	C	11: 5,780,137 (GRCm39)	Q300R	probably benign	Het
Prrc2b	T	A	2: 32,111,467 (GRCm39)	N1208K	probably benign	Het
Serpinb3c	T	C	1: 107,199,648 (GRCm39)	D291G	probably damaging	Het
Skic3	A	G	13: 76,259,810 (GRCm39)	K37E	probably damaging	Het
Slc1a2	T	C	2: 102,578,889 (GRCm39)	F268S	probably damaging	Het
Slc26a4	A	G	12: 31,599,948 (GRCm39)	Y127H	probably damaging	Het
Slc29a4	A	G	5: 142,703,506 (GRCm39)	Y260C	probably damaging	Het
Sorbs3	C	T	14: 70,421,455 (GRCm39)		probably null	Het
Spen	T	C	4: 141,214,917 (GRCm39)	Y534C	unknown	Het
Tmem237	T	C	1: 59,159,270 (GRCm39)		probably null	Het
Tnfrsf21	A	T	17: 43,396,354 (GRCm39)	N546I	probably benign	Het
Tpgs2	T	A	18: 25,273,630 (GRCm39)	D177V	probably damaging	Het
Tpx2	C	T	2: 152,724,240 (GRCm39)	R339*	probably null	Het
Trim12c	T	C	7: 103,997,430 (GRCm39)	Y42C	probably benign	Het
Trip10	A	T	17: 57,564,272 (GRCm39)	E341V	probably damaging	Het
Trpm8	A	T	1: 88,258,416 (GRCm39)		probably null	Het
Ubr1	T	A	2: 120,730,989 (GRCm39)	I1221F	probably benign	Het
Ucp2	C	T	7: 100,148,529 (GRCm39)	A301V	probably benign	Het
Zfyve1	T	C	12: 83,605,467 (GRCm39)	I411V	probably benign	Het

Other mutations in Eif1ad15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01368:Eif1ad15	APN	12	88,287,858 (GRCm39)	missense	unknown
R2029:Eif1ad15	UTSW	12	88,288,191 (GRCm39)	missense	unknown
R2943:Eif1ad15	UTSW	12	88,288,004 (GRCm39)	missense	probably benign	0.04
R5022:Eif1ad15	UTSW	12	88,288,071 (GRCm39)	missense	probably benign	0.08
R5054:Eif1ad15	UTSW	12	88,288,071 (GRCm39)	missense	probably benign	0.08
R5988:Eif1ad15	UTSW	12	88,288,202 (GRCm39)	missense	unknown
R6275:Eif1ad15	UTSW	12	88,287,995 (GRCm39)	missense	possibly damaging	0.95
R6596:Eif1ad15	UTSW	12	88,288,057 (GRCm39)	missense	possibly damaging	0.92
R6863:Eif1ad15	UTSW	12	88,287,968 (GRCm39)	missense	probably damaging	1.00
R8550:Eif1ad15	UTSW	12	88,290,652 (GRCm39)	start gained	probably benign
R8993:Eif1ad15	UTSW	12	88,288,170 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16