Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02183:Vmn2r22'

284293

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r22

Ensembl Gene

ENSMUSG00000095486

Gene Name

vomeronasal 2, receptor 22

Synonyms

EG546913

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL02183

Quality Score

Status

Chromosome

Chromosomal Location

123586717-123627594 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123614963 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 209 (L209P)

Ref Sequence

ENSEMBL: ENSMUSP00000132043 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170808]

AlphaFold

E9Q7S8

Predicted Effect

probably damaging
Transcript: ENSMUST00000170808
AA Change: L209P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: L209P

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	473	1.4e-32	PFAM
Pfam:NCD3G	517	570	2.2e-23	PFAM
Pfam:7tm_3	601	838	1.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ace2	T	A	X: 162,960,465 (GRCm39)		probably benign	Het
Acsm4	A	T	7: 119,293,075 (GRCm39)		probably null	Het
Apcdd1	T	C	18: 63,084,925 (GRCm39)	M374T	probably damaging	Het
Arid4b	A	G	13: 14,344,575 (GRCm39)	E551G	possibly damaging	Het
Bag4	A	T	8: 26,258,058 (GRCm39)	L423Q	probably damaging	Het
Celf1	C	T	2: 90,831,831 (GRCm39)	P96S	probably damaging	Het
Cracdl	G	A	1: 37,664,459 (GRCm39)	P480S	possibly damaging	Het
Cry2	G	A	2: 92,243,384 (GRCm39)	R486W	probably damaging	Het
Csn1s1	G	A	5: 87,825,477 (GRCm39)	S228N	possibly damaging	Het
Ctnnd2	A	G	15: 31,020,886 (GRCm39)	Y1124C	probably damaging	Het
Cyp2j7	T	C	4: 96,118,384 (GRCm39)		probably benign	Het
Dock7	A	T	4: 98,847,228 (GRCm39)	C1695S	possibly damaging	Het
Elmo3	T	C	8: 106,034,955 (GRCm39)	L415P	probably benign	Het
Entpd5	A	G	12: 84,427,154 (GRCm39)		probably benign	Het
Gpatch11	T	C	17: 79,149,660 (GRCm39)		probably null	Het
Gprin3	C	A	6: 59,330,147 (GRCm39)	R720I	possibly damaging	Het
Gria4	T	G	9: 4,502,460 (GRCm39)	T358P	probably damaging	Het
Hcn2	T	C	10: 79,560,647 (GRCm39)		probably null	Het
Hivep3	A	G	4: 119,989,221 (GRCm39)	T1891A	probably benign	Het
Hmgcr	A	G	13: 96,799,635 (GRCm39)	V153A	probably damaging	Het
Ifnar1	T	C	16: 91,302,034 (GRCm39)	V503A	possibly damaging	Het
Igf2r	G	A	17: 12,917,403 (GRCm39)		probably benign	Het
Ighg2b	A	G	12: 113,271,449 (GRCm39)	S35P	unknown	Het
Jmy	T	C	13: 93,635,750 (GRCm39)	D22G	possibly damaging	Het
Kdm5b	T	C	1: 134,552,669 (GRCm39)	I1215T	probably benign	Het
Krt84	T	C	15: 101,440,791 (GRCm39)	I134V	unknown	Het
Magi3	T	A	3: 103,992,663 (GRCm39)	M270L	probably benign	Het
Maneal	G	A	4: 124,754,209 (GRCm39)	T198I	probably benign	Het
Map7d3	A	G	X: 55,867,591 (GRCm39)		probably benign	Het
Myh7	T	A	14: 55,212,188 (GRCm39)	T1519S	probably benign	Het
Myo5a	T	C	9: 75,074,518 (GRCm39)		probably benign	Het
Naip5	T	C	13: 100,358,150 (GRCm39)	S1029G	probably benign	Het
Or14j1	G	T	17: 38,146,304 (GRCm39)	C138F	probably damaging	Het
Or4c11c	A	T	2: 88,662,372 (GRCm39)	I304F	probably benign	Het
Or4g16	T	A	2: 111,136,763 (GRCm39)	V71E	probably damaging	Het
Or5d14	T	C	2: 87,880,333 (GRCm39)	T212A	possibly damaging	Het
Or5k15	T	A	16: 58,710,184 (GRCm39)	Q133L	probably benign	Het
Pald1	A	T	10: 61,182,920 (GRCm39)		probably benign	Het
Pan2	T	A	10: 128,144,944 (GRCm39)	H230Q	possibly damaging	Het
Pcdh9	T	C	14: 94,123,720 (GRCm39)	I817V	probably benign	Het
Piezo2	A	G	18: 63,153,705 (GRCm39)	S2547P	probably benign	Het
Ppargc1b	T	A	18: 61,442,167 (GRCm39)		probably null	Het
Prdm6	T	C	18: 53,597,749 (GRCm39)		probably benign	Het
Prr5l	A	T	2: 101,602,465 (GRCm39)		probably benign	Het
Rab3gap2	T	A	1: 185,003,665 (GRCm39)	L1020*	probably null	Het
Rhbdf1	T	C	11: 32,160,543 (GRCm39)	H669R	probably damaging	Het
Rnf150	A	T	8: 83,730,234 (GRCm39)	I255F	probably damaging	Het
Rnf17	T	A	14: 56,745,325 (GRCm39)	D1360E	probably null	Het
Sag	T	C	1: 87,756,197 (GRCm39)		probably null	Het
Scn2a	C	T	2: 65,501,947 (GRCm39)	T90I	probably benign	Het
Scn9a	T	A	2: 66,314,955 (GRCm39)		probably benign	Het
Serpinb13	T	C	1: 106,926,640 (GRCm39)	M212T	probably damaging	Het
Slc39a14	C	T	14: 70,544,134 (GRCm39)	G484E	possibly damaging	Het
Slco1a1	A	T	6: 141,867,669 (GRCm39)		probably benign	Het
Slitrk3	A	T	3: 72,957,312 (GRCm39)	Y487N	probably damaging	Het
Stkld1	T	C	2: 26,836,671 (GRCm39)	M279T	probably benign	Het
Tmem161b	T	C	13: 84,420,373 (GRCm39)	Y125H	probably damaging	Het
Tmem71	A	G	15: 66,426,874 (GRCm39)		probably benign	Het
Ubxn7	T	C	16: 32,188,201 (GRCm39)	F142L	probably damaging	Het
Wdr73	A	T	7: 80,543,508 (GRCm39)	W136R	probably damaging	Het
Wif1	C	T	10: 120,911,181 (GRCm39)	R107C	probably damaging	Het
Ythdf2	G	T	4: 131,932,885 (GRCm39)	L92M	probably benign	Het
Zfp53	T	A	17: 21,720,512 (GRCm39)	I34N	possibly damaging	Het
Zpld2	A	G	4: 133,929,291 (GRCm39)	L338S	probably benign	Het

Other mutations in Vmn2r22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01024:Vmn2r22	APN	6	123,615,012 (GRCm39)	missense	probably damaging	1.00
IGL01764:Vmn2r22	APN	6	123,627,379 (GRCm39)	critical splice donor site	probably null
IGL02037:Vmn2r22	APN	6	123,626,026 (GRCm39)	missense	probably damaging	1.00
IGL02335:Vmn2r22	APN	6	123,615,051 (GRCm39)	missense	probably damaging	0.99
IGL02440:Vmn2r22	APN	6	123,614,364 (GRCm39)	missense	probably benign	0.00
IGL02663:Vmn2r22	APN	6	123,626,117 (GRCm39)	missense	probably benign	0.11
IGL03101:Vmn2r22	APN	6	123,614,295 (GRCm39)	missense	probably benign	0.09
R0266:Vmn2r22	UTSW	6	123,614,363 (GRCm39)	missense	probably damaging	0.99
R0348:Vmn2r22	UTSW	6	123,614,684 (GRCm39)	missense	probably damaging	1.00
R0780:Vmn2r22	UTSW	6	123,614,933 (GRCm39)	missense	probably damaging	1.00
R0849:Vmn2r22	UTSW	6	123,614,363 (GRCm39)	missense	probably damaging	0.99
R1074:Vmn2r22	UTSW	6	123,626,217 (GRCm39)	missense	probably benign	0.02
R1456:Vmn2r22	UTSW	6	123,614,624 (GRCm39)	missense	possibly damaging	0.86
R1719:Vmn2r22	UTSW	6	123,614,802 (GRCm39)	missense	possibly damaging	0.68
R1989:Vmn2r22	UTSW	6	123,614,500 (GRCm39)	missense	probably damaging	1.00
R2928:Vmn2r22	UTSW	6	123,614,402 (GRCm39)	missense	probably damaging	0.96
R2939:Vmn2r22	UTSW	6	123,614,594 (GRCm39)	missense	probably damaging	0.99
R3727:Vmn2r22	UTSW	6	123,627,584 (GRCm39)	missense	possibly damaging	0.70
R3782:Vmn2r22	UTSW	6	123,627,591 (GRCm39)	nonsense	probably null
R3873:Vmn2r22	UTSW	6	123,614,339 (GRCm39)	missense	possibly damaging	0.68
R4344:Vmn2r22	UTSW	6	123,614,756 (GRCm39)	missense	probably damaging	1.00
R4407:Vmn2r22	UTSW	6	123,614,913 (GRCm39)	missense	probably damaging	1.00
R4428:Vmn2r22	UTSW	6	123,614,817 (GRCm39)	missense	possibly damaging	0.47
R4430:Vmn2r22	UTSW	6	123,614,817 (GRCm39)	missense	possibly damaging	0.47
R4431:Vmn2r22	UTSW	6	123,614,817 (GRCm39)	missense	possibly damaging	0.47
R4701:Vmn2r22	UTSW	6	123,627,428 (GRCm39)	missense	probably benign	0.00
R5274:Vmn2r22	UTSW	6	123,627,593 (GRCm39)	start codon destroyed	probably null	0.93
R5668:Vmn2r22	UTSW	6	123,614,873 (GRCm39)	missense	probably benign	0.06
R5776:Vmn2r22	UTSW	6	123,614,673 (GRCm39)	missense	probably damaging	1.00
R6416:Vmn2r22	UTSW	6	123,614,697 (GRCm39)	missense	probably damaging	1.00
R7788:Vmn2r22	UTSW	6	123,614,559 (GRCm39)	missense	not run
R8208:Vmn2r22	UTSW	6	123,614,444 (GRCm39)	missense	probably damaging	1.00
R8267:Vmn2r22	UTSW	6	123,615,000 (GRCm39)	missense	possibly damaging	0.81
R8400:Vmn2r22	UTSW	6	123,614,486 (GRCm39)	nonsense	probably null
R8814:Vmn2r22	UTSW	6	123,614,789 (GRCm39)	missense	probably damaging	0.96
R8850:Vmn2r22	UTSW	6	123,614,454 (GRCm39)	missense	probably damaging	1.00
R9613:Vmn2r22	UTSW	6	123,615,075 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16