Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02202:Zc3h6'

284371

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zc3h6

Ensembl Gene

ENSMUSG00000042851

Gene Name

zinc finger CCCH type containing 6

Synonyms

4631426G04Rik, 4833425H18Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.197) question?

Stock #

IGL02202

Quality Score

Status

Chromosome

Chromosomal Location

128809322-128860483 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 128858501 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 844 (L844P)

Ref Sequence

ENSEMBL: ENSMUSP00000105949 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110320]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000110320
AA Change: L844P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000105949
Gene: ENSMUSG00000042851
AA Change: L844P

Domain	Start	End	E-Value	Type
low complexity region	8	25	N/A	INTRINSIC
coiled coil region	30	71	N/A	INTRINSIC
low complexity region	74	88	N/A	INTRINSIC
low complexity region	177	192	N/A	INTRINSIC
ZnF_C3H1	271	296	1.72e-4	SMART
ZnF_C3H1	300	325	2.51e-6	SMART
ZnF_C3H1	326	349	5.24e0	SMART
coiled coil region	351	383	N/A	INTRINSIC
low complexity region	385	400	N/A	INTRINSIC
low complexity region	493	509	N/A	INTRINSIC
low complexity region	698	707	N/A	INTRINSIC
low complexity region	784	798	N/A	INTRINSIC
low complexity region	815	829	N/A	INTRINSIC
low complexity region	876	890	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135186

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	C	T	11: 9,238,529 (GRCm39)	T709I	possibly damaging	Het
Acte1	T	A	7: 143,447,910 (GRCm39)	M251K	possibly damaging	Het
Arhgef1	T	A	7: 24,612,854 (GRCm39)	Y185*	probably null	Het
Atxn7l1	T	C	12: 33,392,077 (GRCm39)	S218P	probably benign	Het
Cd200r2	T	A	16: 44,729,723 (GRCm39)	L126Q	probably damaging	Het
Cdc6	T	A	11: 98,811,641 (GRCm39)		probably null	Het
Cenph	T	C	13: 100,898,381 (GRCm39)	N174S	probably benign	Het
Cep192	A	G	18: 67,936,207 (GRCm39)	R49G	possibly damaging	Het
Edrf1	A	G	7: 133,258,699 (GRCm39)	T692A	probably benign	Het
Frem2	A	T	3: 53,562,220 (GRCm39)	H762Q	probably benign	Het
Gli2	T	C	1: 118,764,596 (GRCm39)	D1185G	probably damaging	Het
Hsd3b2	T	A	3: 98,619,183 (GRCm39)	Y254F	possibly damaging	Het
Itgal	C	A	7: 126,929,351 (GRCm39)	Y1089*	probably null	Het
Klf11	T	G	12: 24,703,631 (GRCm39)	V22G	probably benign	Het
Morc3	T	C	16: 93,667,749 (GRCm39)	V636A	probably benign	Het
Nin	T	A	12: 70,102,210 (GRCm39)	D330V	probably damaging	Het
Nlrp4a	G	T	7: 26,148,703 (GRCm39)	K103N	possibly damaging	Het
Ntsr2	T	A	12: 16,703,661 (GRCm39)	V54E	probably damaging	Het
Or7g27	C	A	9: 19,250,545 (GRCm39)	A263E	probably benign	Het
Pdha2	T	C	3: 140,916,412 (GRCm39)	I365M	probably benign	Het
Prr19	T	C	7: 25,003,462 (GRCm39)	S359P	probably damaging	Het
Ryr2	T	C	13: 11,745,274 (GRCm39)	K2040E	probably damaging	Het
Ryr2	C	A	13: 11,762,544 (GRCm39)		probably benign	Het
Sema4a	G	T	3: 88,357,050 (GRCm39)	A307E	probably damaging	Het
Setd5	T	A	6: 113,127,976 (GRCm39)	S1310T	probably benign	Het
Tph1	A	T	7: 46,303,185 (GRCm39)	D264E	probably benign	Het

Other mutations in Zc3h6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01732:Zc3h6	APN	2	128,853,795 (GRCm39)	missense	probably damaging	1.00
IGL01880:Zc3h6	APN	2	128,859,298 (GRCm39)	missense	probably damaging	0.99
IGL02160:Zc3h6	APN	2	128,839,605 (GRCm39)	missense	probably benign	0.02
IGL02161:Zc3h6	APN	2	128,835,146 (GRCm39)	missense	possibly damaging	0.90
IGL02547:Zc3h6	APN	2	128,857,531 (GRCm39)	missense	probably benign	0.00
IGL02973:Zc3h6	APN	2	128,839,715 (GRCm39)	missense	probably damaging	0.98
BB001:Zc3h6	UTSW	2	128,857,400 (GRCm39)	missense	possibly damaging	0.52
BB011:Zc3h6	UTSW	2	128,857,400 (GRCm39)	missense	possibly damaging	0.52
R0336:Zc3h6	UTSW	2	128,857,332 (GRCm39)	missense	possibly damaging	0.81
R0420:Zc3h6	UTSW	2	128,856,747 (GRCm39)	missense	probably benign	0.00
R0538:Zc3h6	UTSW	2	128,859,143 (GRCm39)	missense	possibly damaging	0.75
R0944:Zc3h6	UTSW	2	128,848,736 (GRCm39)	missense	probably damaging	1.00
R1151:Zc3h6	UTSW	2	128,859,056 (GRCm39)	missense	probably benign	0.00
R1528:Zc3h6	UTSW	2	128,858,989 (GRCm39)	missense	probably benign	0.01
R1698:Zc3h6	UTSW	2	128,859,278 (GRCm39)	missense	probably benign
R1712:Zc3h6	UTSW	2	128,858,654 (GRCm39)	missense	probably damaging	1.00
R1913:Zc3h6	UTSW	2	128,858,540 (GRCm39)	missense	probably damaging	1.00
R1926:Zc3h6	UTSW	2	128,839,715 (GRCm39)	missense	probably damaging	0.98
R2030:Zc3h6	UTSW	2	128,848,006 (GRCm39)	missense	probably damaging	1.00
R2051:Zc3h6	UTSW	2	128,857,538 (GRCm39)	missense	possibly damaging	0.55
R2133:Zc3h6	UTSW	2	128,809,750 (GRCm39)	missense	possibly damaging	0.53
R2273:Zc3h6	UTSW	2	128,856,629 (GRCm39)	missense	probably benign	0.01
R2328:Zc3h6	UTSW	2	128,835,122 (GRCm39)	missense	possibly damaging	0.85
R2862:Zc3h6	UTSW	2	128,857,380 (GRCm39)	missense	probably benign	0.43
R2899:Zc3h6	UTSW	2	128,844,152 (GRCm39)	missense	probably benign	0.00
R3711:Zc3h6	UTSW	2	128,859,251 (GRCm39)	missense	probably benign	0.00
R3743:Zc3h6	UTSW	2	128,839,712 (GRCm39)	missense	probably damaging	1.00
R3893:Zc3h6	UTSW	2	128,858,060 (GRCm39)	missense	probably damaging	1.00
R4748:Zc3h6	UTSW	2	128,844,160 (GRCm39)	missense	probably damaging	1.00
R5025:Zc3h6	UTSW	2	128,852,353 (GRCm39)	missense	possibly damaging	0.87
R5026:Zc3h6	UTSW	2	128,859,229 (GRCm39)	missense	probably benign	0.00
R5125:Zc3h6	UTSW	2	128,856,399 (GRCm39)	missense	possibly damaging	0.93
R5373:Zc3h6	UTSW	2	128,844,076 (GRCm39)	missense	possibly damaging	0.75
R5374:Zc3h6	UTSW	2	128,844,076 (GRCm39)	missense	possibly damaging	0.75
R5703:Zc3h6	UTSW	2	128,835,372 (GRCm39)	intron	probably benign
R5802:Zc3h6	UTSW	2	128,857,479 (GRCm39)	missense	possibly damaging	0.56
R5876:Zc3h6	UTSW	2	128,835,197 (GRCm39)	missense	probably benign	0.29
R5879:Zc3h6	UTSW	2	128,839,696 (GRCm39)	splice site	probably null
R5950:Zc3h6	UTSW	2	128,839,710 (GRCm39)	nonsense	probably null
R6031:Zc3h6	UTSW	2	128,809,732 (GRCm39)	missense	possibly damaging	0.85
R6031:Zc3h6	UTSW	2	128,809,732 (GRCm39)	missense	possibly damaging	0.85
R6781:Zc3h6	UTSW	2	128,857,341 (GRCm39)	missense	probably damaging	0.99
R7323:Zc3h6	UTSW	2	128,835,331 (GRCm39)	missense	unknown
R7340:Zc3h6	UTSW	2	128,835,110 (GRCm39)	missense	possibly damaging	0.90
R7572:Zc3h6	UTSW	2	128,859,172 (GRCm39)	missense	probably benign	0.02
R7576:Zc3h6	UTSW	2	128,856,473 (GRCm39)	missense	probably damaging	1.00
R7797:Zc3h6	UTSW	2	128,857,555 (GRCm39)	critical splice donor site	probably null
R7924:Zc3h6	UTSW	2	128,857,400 (GRCm39)	missense	possibly damaging	0.52
R8048:Zc3h6	UTSW	2	128,858,934 (GRCm39)	missense	probably benign	0.30
R8877:Zc3h6	UTSW	2	128,856,319 (GRCm39)	nonsense	probably null
R9076:Zc3h6	UTSW	2	128,859,096 (GRCm39)	nonsense	probably null
R9577:Zc3h6	UTSW	2	128,858,102 (GRCm39)	missense
R9687:Zc3h6	UTSW	2	128,859,281 (GRCm39)	missense	probably damaging	1.00
R9745:Zc3h6	UTSW	2	128,859,155 (GRCm39)	missense	probably benign	0.08
Z1176:Zc3h6	UTSW	2	128,858,141 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16