Incidental Mutation 'IGL02209:Olfr641'
ID284617
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr641
Ensembl Gene ENSMUSG00000073932
Gene Nameolfactory receptor 641
SynonymsMOR13-3, GA_x6K02T2PBJ9-6773690-6774628
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.220) question?
Stock #IGL02209
Quality Score
Status
Chromosome7
Chromosomal Location104035445-104042072 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 104040456 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Arginine at position 220 (L220R)
Ref Sequence ENSEMBL: ENSMUSP00000149866 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098183] [ENSMUST00000138055] [ENSMUST00000213214]
Predicted Effect probably damaging
Transcript: ENSMUST00000098183
AA Change: L220R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000095785
Gene: ENSMUSG00000073932
AA Change: L220R

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 2.5e-118 PFAM
Pfam:7TM_GPCR_Srsx 35 307 7e-7 PFAM
Pfam:7tm_1 41 292 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000213214
AA Change: L220R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213904
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf1 C T 17: 35,964,009 R82Q probably damaging Het
Acmsd A G 1: 127,759,755 Y258C probably damaging Het
Anapc5 A G 5: 122,800,613 I366T possibly damaging Het
Crkl C T 16: 17,469,234 T218I probably benign Het
Egf A T 3: 129,707,307 I213K possibly damaging Het
Fry A G 5: 150,437,026 T33A probably benign Het
Garnl3 T C 2: 33,085,930 D93G probably damaging Het
Hook3 C T 8: 26,070,265 D311N probably damaging Het
Iglv3 T C 16: 19,241,670 T4A probably benign Het
Kctd17 A G 15: 78,435,592 N70S probably damaging Het
Kmt2d T C 15: 98,854,567 probably benign Het
Lrif1 A C 3: 106,731,729 L18F probably damaging Het
Mfsd1 A G 3: 67,598,132 probably benign Het
Msh4 A G 3: 153,888,862 Y101H probably damaging Het
Mycbpap G A 11: 94,509,882 probably benign Het
Myt1 A G 2: 181,797,234 D183G probably benign Het
Nppc T C 1: 86,669,665 *127W probably null Het
Olfr119 G A 17: 37,700,992 M107I probably damaging Het
Olfr138 A G 17: 38,275,232 I154V probably benign Het
Olfr356 C T 2: 36,937,505 P129S probably damaging Het
Olfr918 T C 9: 38,673,046 K146E possibly damaging Het
Pde5a A G 3: 122,825,015 probably benign Het
Pkd1l3 T C 8: 109,638,664 V1139A probably damaging Het
Pwwp2b G A 7: 139,255,105 R154Q probably damaging Het
Satb2 C T 1: 56,871,518 V264I probably damaging Het
Slc6a2 T A 8: 92,994,060 F435Y probably benign Het
Stmn2 T C 3: 8,560,261 probably benign Het
Synj1 A G 16: 90,987,419 I277T probably damaging Het
Trio C T 15: 27,744,053 A2598T probably damaging Het
Tshz2 G A 2: 169,884,764 V427M probably damaging Het
Utrn A G 10: 12,683,295 S1405P probably damaging Het
Vmn1r173 G A 7: 23,703,161 V274I probably benign Het
Vmn2r116 T C 17: 23,388,787 F443S probably damaging Het
Vps13d C A 4: 145,156,101 R974L probably damaging Het
Wapl T A 14: 34,677,261 S96T possibly damaging Het
Zfp516 A G 18: 82,994,497 D1125G probably benign Het
Zfp692 C T 11: 58,313,998 R395* probably null Het
Other mutations in Olfr641
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Olfr641 APN 7 104039844 missense probably damaging 1.00
IGL01515:Olfr641 APN 7 104039976 missense probably benign 0.03
IGL01940:Olfr641 APN 7 104039922 missense probably damaging 1.00
IGL02486:Olfr641 APN 7 104040410 missense probably damaging 1.00
R2075:Olfr641 UTSW 7 104039973 missense probably damaging 0.97
R4110:Olfr641 UTSW 7 104040402 missense probably damaging 1.00
Posted On2015-04-16