Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02209:Iglv3'

284635

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Iglv3

Ensembl Gene

ENSMUSG00000076939

Gene Name

immunoglobulin lambda variable 3

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL02209

Quality Score

Status

Chromosome

Chromosomal Location

19059958-19060429 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19060420 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 4 (T4A)

Ref Sequence

ENSEMBL: ENSMUSP00000100465 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103751]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000103751
AA Change: T4A

PolyPhen 2 Score 0.049 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000100465
Gene: ENSMUSG00000076939
AA Change: T4A

Domain	Start	End	E-Value	Type
IGv	36	113	8.97e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000197818

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199551

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcf1	C	T	17: 36,274,901 (GRCm39)	R82Q	probably damaging	Het
Acmsd	A	G	1: 127,687,492 (GRCm39)	Y258C	probably damaging	Het
Anapc5	A	G	5: 122,938,676 (GRCm39)	I366T	possibly damaging	Het
Crkl	C	T	16: 17,287,098 (GRCm39)	T218I	probably benign	Het
Egf	A	T	3: 129,500,956 (GRCm39)	I213K	possibly damaging	Het
Fry	A	G	5: 150,360,491 (GRCm39)	T33A	probably benign	Het
Garnl3	T	C	2: 32,975,942 (GRCm39)	D93G	probably damaging	Het
Hook3	C	T	8: 26,560,293 (GRCm39)	D311N	probably damaging	Het
Kctd17	A	G	15: 78,319,792 (GRCm39)	N70S	probably damaging	Het
Kmt2d	T	C	15: 98,752,448 (GRCm39)		probably benign	Het
Lrif1	A	C	3: 106,639,045 (GRCm39)	L18F	probably damaging	Het
Mfsd1	A	G	3: 67,505,465 (GRCm39)		probably benign	Het
Msh4	A	G	3: 153,594,499 (GRCm39)	Y101H	probably damaging	Het
Mycbpap	G	A	11: 94,400,708 (GRCm39)		probably benign	Het
Myt1	A	G	2: 181,439,027 (GRCm39)	D183G	probably benign	Het
Nppc	T	C	1: 86,597,387 (GRCm39)	*127W	probably null	Het
Or10al3	G	A	17: 38,011,883 (GRCm39)	M107I	probably damaging	Het
Or1ak2	C	T	2: 36,827,517 (GRCm39)	P129S	probably damaging	Het
Or2n1e	A	G	17: 38,586,123 (GRCm39)	I154V	probably benign	Het
Or51i2	T	G	7: 103,689,663 (GRCm39)	L220R	probably damaging	Het
Or8b3b	T	C	9: 38,584,342 (GRCm39)	K146E	possibly damaging	Het
Pde5a	A	G	3: 122,618,664 (GRCm39)		probably benign	Het
Pkd1l3	T	C	8: 110,365,296 (GRCm39)	V1139A	probably damaging	Het
Pwwp2b	G	A	7: 138,835,021 (GRCm39)	R154Q	probably damaging	Het
Satb2	C	T	1: 56,910,677 (GRCm39)	V264I	probably damaging	Het
Slc6a2	T	A	8: 93,720,688 (GRCm39)	F435Y	probably benign	Het
Stmn2	T	C	3: 8,625,321 (GRCm39)		probably benign	Het
Synj1	A	G	16: 90,784,307 (GRCm39)	I277T	probably damaging	Het
Trio	C	T	15: 27,744,139 (GRCm39)	A2598T	probably damaging	Het
Tshz2	G	A	2: 169,726,684 (GRCm39)	V427M	probably damaging	Het
Utrn	A	G	10: 12,559,039 (GRCm39)	S1405P	probably damaging	Het
Vmn1r173	G	A	7: 23,402,586 (GRCm39)	V274I	probably benign	Het
Vmn2r116	T	C	17: 23,607,761 (GRCm39)	F443S	probably damaging	Het
Vps13d	C	A	4: 144,882,671 (GRCm39)	R974L	probably damaging	Het
Wapl	T	A	14: 34,399,218 (GRCm39)	S96T	possibly damaging	Het
Zfp516	A	G	18: 83,012,622 (GRCm39)	D1125G	probably benign	Het
Zfp692	C	T	11: 58,204,824 (GRCm39)	R395*	probably null	Het

Other mutations in Iglv3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02140:Iglv3	APN	16	19,060,160 (GRCm39)	missense	probably damaging	1.00
R6241:Iglv3	UTSW	16	19,059,968 (GRCm39)	missense	possibly damaging	0.81
R6814:Iglv3	UTSW	16	19,060,034 (GRCm39)	missense	probably damaging	1.00
R6872:Iglv3	UTSW	16	19,060,034 (GRCm39)	missense	probably damaging	1.00
R8838:Iglv3	UTSW	16	19,060,132 (GRCm39)	nonsense	probably null
R9158:Iglv3	UTSW	16	19,060,012 (GRCm39)	missense	probably damaging	0.99
R9585:Iglv3	UTSW	16	19,059,960 (GRCm39)	makesense	probably null
R9609:Iglv3	UTSW	16	19,060,221 (GRCm39)	missense	probably damaging	1.00
Z1177:Iglv3	UTSW	16	19,060,202 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16