Incidental Mutation 'IGL02209:Vmn1r173'
ID284641
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r173
Ensembl Gene ENSMUSG00000115021
Gene Namevomeronasal 1 receptor 173
SynonymsGm5892
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.544) question?
Stock #IGL02209
Quality Score
Status
Chromosome7
Chromosomal Location23700703-23711009 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 23703161 bp
ZygosityHeterozygous
Amino Acid Change Valine to Isoleucine at position 274 (V274I)
Ref Sequence ENSEMBL: ENSMUSP00000153884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174055] [ENSMUST00000226233] [ENSMUST00000227987]
Predicted Effect probably benign
Transcript: ENSMUST00000174055
AA Change: V274I

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: V274I

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:V1R 43 301 5.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226233
AA Change: V274I

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000227987
AA Change: V274I

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf1 C T 17: 35,964,009 R82Q probably damaging Het
Acmsd A G 1: 127,759,755 Y258C probably damaging Het
Anapc5 A G 5: 122,800,613 I366T possibly damaging Het
Crkl C T 16: 17,469,234 T218I probably benign Het
Egf A T 3: 129,707,307 I213K possibly damaging Het
Fry A G 5: 150,437,026 T33A probably benign Het
Garnl3 T C 2: 33,085,930 D93G probably damaging Het
Hook3 C T 8: 26,070,265 D311N probably damaging Het
Iglv3 T C 16: 19,241,670 T4A probably benign Het
Kctd17 A G 15: 78,435,592 N70S probably damaging Het
Kmt2d T C 15: 98,854,567 probably benign Het
Lrif1 A C 3: 106,731,729 L18F probably damaging Het
Mfsd1 A G 3: 67,598,132 probably benign Het
Msh4 A G 3: 153,888,862 Y101H probably damaging Het
Mycbpap G A 11: 94,509,882 probably benign Het
Myt1 A G 2: 181,797,234 D183G probably benign Het
Nppc T C 1: 86,669,665 *127W probably null Het
Olfr119 G A 17: 37,700,992 M107I probably damaging Het
Olfr138 A G 17: 38,275,232 I154V probably benign Het
Olfr356 C T 2: 36,937,505 P129S probably damaging Het
Olfr641 T G 7: 104,040,456 L220R probably damaging Het
Olfr918 T C 9: 38,673,046 K146E possibly damaging Het
Pde5a A G 3: 122,825,015 probably benign Het
Pkd1l3 T C 8: 109,638,664 V1139A probably damaging Het
Pwwp2b G A 7: 139,255,105 R154Q probably damaging Het
Satb2 C T 1: 56,871,518 V264I probably damaging Het
Slc6a2 T A 8: 92,994,060 F435Y probably benign Het
Stmn2 T C 3: 8,560,261 probably benign Het
Synj1 A G 16: 90,987,419 I277T probably damaging Het
Trio C T 15: 27,744,053 A2598T probably damaging Het
Tshz2 G A 2: 169,884,764 V427M probably damaging Het
Utrn A G 10: 12,683,295 S1405P probably damaging Het
Vmn2r116 T C 17: 23,388,787 F443S probably damaging Het
Vps13d C A 4: 145,156,101 R974L probably damaging Het
Wapl T A 14: 34,677,261 S96T possibly damaging Het
Zfp516 A G 18: 82,994,497 D1125G probably benign Het
Zfp692 C T 11: 58,313,998 R395* probably null Het
Other mutations in Vmn1r173
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01490:Vmn1r173 APN 7 23702707 missense probably benign 0.01
IGL01637:Vmn1r173 APN 7 23702948 missense probably damaging 0.96
IGL01878:Vmn1r173 APN 7 23702452 missense probably damaging 1.00
IGL02036:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02039:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02171:Vmn1r173 APN 7 23702896 missense probably benign 0.04
R0157:Vmn1r173 UTSW 7 23702397 missense probably damaging 0.99
R0226:Vmn1r173 UTSW 7 23703083 missense possibly damaging 0.65
R0482:Vmn1r173 UTSW 7 23702791 missense probably damaging 0.99
R0792:Vmn1r173 UTSW 7 23702735 missense probably benign 0.01
R1242:Vmn1r173 UTSW 7 23703225 missense probably damaging 1.00
R1390:Vmn1r173 UTSW 7 23702898 missense possibly damaging 0.82
R1641:Vmn1r173 UTSW 7 23703108 missense probably benign 0.06
R1867:Vmn1r173 UTSW 7 23703235 missense unknown
R2325:Vmn1r173 UTSW 7 23703112 nonsense probably null
R3863:Vmn1r173 UTSW 7 23702552 missense probably damaging 1.00
R4407:Vmn1r173 UTSW 7 23703016 missense probably damaging 1.00
R4717:Vmn1r173 UTSW 7 23703212 missense probably damaging 1.00
R4841:Vmn1r173 UTSW 7 23702936 missense probably damaging 1.00
R4842:Vmn1r173 UTSW 7 23702936 missense probably damaging 1.00
R5966:Vmn1r173 UTSW 7 23702687 missense probably benign 0.00
R6022:Vmn1r173 UTSW 7 23702835 missense probably benign 0.07
R6114:Vmn1r173 UTSW 7 23702829 missense possibly damaging 0.53
R6657:Vmn1r173 UTSW 7 23702895 missense probably damaging 0.98
X0022:Vmn1r173 UTSW 7 23702587 missense probably benign 0.06
Posted On2015-04-16