Incidental Mutation 'IGL02209:Vmn1r173'
| ID |
284641 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r173
|
| Ensembl Gene |
ENSMUSG00000115021 |
| Gene Name |
vomeronasal 1 receptor 173 |
| Synonyms |
Gm5892 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.621)
|
| Stock # |
IGL02209
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23401767-23402708 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 23402586 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 274
(V274I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153884
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000174055]
[ENSMUST00000226233]
[ENSMUST00000227987]
|
| AlphaFold |
E9Q8V7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174055
AA Change: V274I
PolyPhen 2
Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: V274I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
13 |
35 |
N/A |
INTRINSIC |
|
Pfam:V1R
|
43 |
301 |
5.3e-20 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226233
AA Change: V274I
PolyPhen 2
Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227987
AA Change: V274I
PolyPhen 2
Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcf1 |
C |
T |
17: 36,274,901 (GRCm39) |
R82Q |
probably damaging |
Het |
| Acmsd |
A |
G |
1: 127,687,492 (GRCm39) |
Y258C |
probably damaging |
Het |
| Anapc5 |
A |
G |
5: 122,938,676 (GRCm39) |
I366T |
possibly damaging |
Het |
| Crkl |
C |
T |
16: 17,287,098 (GRCm39) |
T218I |
probably benign |
Het |
| Egf |
A |
T |
3: 129,500,956 (GRCm39) |
I213K |
possibly damaging |
Het |
| Fry |
A |
G |
5: 150,360,491 (GRCm39) |
T33A |
probably benign |
Het |
| Garnl3 |
T |
C |
2: 32,975,942 (GRCm39) |
D93G |
probably damaging |
Het |
| Hook3 |
C |
T |
8: 26,560,293 (GRCm39) |
D311N |
probably damaging |
Het |
| Iglv3 |
T |
C |
16: 19,060,420 (GRCm39) |
T4A |
probably benign |
Het |
| Kctd17 |
A |
G |
15: 78,319,792 (GRCm39) |
N70S |
probably damaging |
Het |
| Kmt2d |
T |
C |
15: 98,752,448 (GRCm39) |
|
probably benign |
Het |
| Lrif1 |
A |
C |
3: 106,639,045 (GRCm39) |
L18F |
probably damaging |
Het |
| Mfsd1 |
A |
G |
3: 67,505,465 (GRCm39) |
|
probably benign |
Het |
| Msh4 |
A |
G |
3: 153,594,499 (GRCm39) |
Y101H |
probably damaging |
Het |
| Mycbpap |
G |
A |
11: 94,400,708 (GRCm39) |
|
probably benign |
Het |
| Myt1 |
A |
G |
2: 181,439,027 (GRCm39) |
D183G |
probably benign |
Het |
| Nppc |
T |
C |
1: 86,597,387 (GRCm39) |
*127W |
probably null |
Het |
| Or10al3 |
G |
A |
17: 38,011,883 (GRCm39) |
M107I |
probably damaging |
Het |
| Or1ak2 |
C |
T |
2: 36,827,517 (GRCm39) |
P129S |
probably damaging |
Het |
| Or2n1e |
A |
G |
17: 38,586,123 (GRCm39) |
I154V |
probably benign |
Het |
| Or51i2 |
T |
G |
7: 103,689,663 (GRCm39) |
L220R |
probably damaging |
Het |
| Or8b3b |
T |
C |
9: 38,584,342 (GRCm39) |
K146E |
possibly damaging |
Het |
| Pde5a |
A |
G |
3: 122,618,664 (GRCm39) |
|
probably benign |
Het |
| Pkd1l3 |
T |
C |
8: 110,365,296 (GRCm39) |
V1139A |
probably damaging |
Het |
| Pwwp2b |
G |
A |
7: 138,835,021 (GRCm39) |
R154Q |
probably damaging |
Het |
| Satb2 |
C |
T |
1: 56,910,677 (GRCm39) |
V264I |
probably damaging |
Het |
| Slc6a2 |
T |
A |
8: 93,720,688 (GRCm39) |
F435Y |
probably benign |
Het |
| Stmn2 |
T |
C |
3: 8,625,321 (GRCm39) |
|
probably benign |
Het |
| Synj1 |
A |
G |
16: 90,784,307 (GRCm39) |
I277T |
probably damaging |
Het |
| Trio |
C |
T |
15: 27,744,139 (GRCm39) |
A2598T |
probably damaging |
Het |
| Tshz2 |
G |
A |
2: 169,726,684 (GRCm39) |
V427M |
probably damaging |
Het |
| Utrn |
A |
G |
10: 12,559,039 (GRCm39) |
S1405P |
probably damaging |
Het |
| Vmn2r116 |
T |
C |
17: 23,607,761 (GRCm39) |
F443S |
probably damaging |
Het |
| Vps13d |
C |
A |
4: 144,882,671 (GRCm39) |
R974L |
probably damaging |
Het |
| Wapl |
T |
A |
14: 34,399,218 (GRCm39) |
S96T |
possibly damaging |
Het |
| Zfp516 |
A |
G |
18: 83,012,622 (GRCm39) |
D1125G |
probably benign |
Het |
| Zfp692 |
C |
T |
11: 58,204,824 (GRCm39) |
R395* |
probably null |
Het |
|
| Other mutations in Vmn1r173 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01490:Vmn1r173
|
APN |
7 |
23,402,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01637:Vmn1r173
|
APN |
7 |
23,402,373 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01878:Vmn1r173
|
APN |
7 |
23,401,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02036:Vmn1r173
|
APN |
7 |
23,402,321 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02039:Vmn1r173
|
APN |
7 |
23,402,321 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02171:Vmn1r173
|
APN |
7 |
23,402,321 (GRCm39) |
missense |
probably benign |
0.04 |
|
PIT4515001:Vmn1r173
|
UTSW |
7 |
23,401,911 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Vmn1r173
|
UTSW |
7 |
23,401,822 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0226:Vmn1r173
|
UTSW |
7 |
23,402,508 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0482:Vmn1r173
|
UTSW |
7 |
23,402,216 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0792:Vmn1r173
|
UTSW |
7 |
23,402,160 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1242:Vmn1r173
|
UTSW |
7 |
23,402,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1390:Vmn1r173
|
UTSW |
7 |
23,402,323 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1641:Vmn1r173
|
UTSW |
7 |
23,402,533 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1867:Vmn1r173
|
UTSW |
7 |
23,402,660 (GRCm39) |
missense |
unknown |
|
|
R2325:Vmn1r173
|
UTSW |
7 |
23,402,537 (GRCm39) |
nonsense |
probably null |
|
|
R3863:Vmn1r173
|
UTSW |
7 |
23,401,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4407:Vmn1r173
|
UTSW |
7 |
23,402,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4717:Vmn1r173
|
UTSW |
7 |
23,402,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Vmn1r173
|
UTSW |
7 |
23,402,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Vmn1r173
|
UTSW |
7 |
23,402,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Vmn1r173
|
UTSW |
7 |
23,402,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6022:Vmn1r173
|
UTSW |
7 |
23,402,260 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6114:Vmn1r173
|
UTSW |
7 |
23,402,254 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6657:Vmn1r173
|
UTSW |
7 |
23,402,320 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7165:Vmn1r173
|
UTSW |
7 |
23,402,076 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn1r173
|
UTSW |
7 |
23,401,884 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7201:Vmn1r173
|
UTSW |
7 |
23,401,583 (GRCm39) |
start gained |
probably benign |
|
|
R7533:Vmn1r173
|
UTSW |
7 |
23,402,071 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7951:Vmn1r173
|
UTSW |
7 |
23,402,680 (GRCm39) |
missense |
unknown |
|
|
R8351:Vmn1r173
|
UTSW |
7 |
23,401,957 (GRCm39) |
nonsense |
probably null |
|
|
R8374:Vmn1r173
|
UTSW |
7 |
23,401,920 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8427:Vmn1r173
|
UTSW |
7 |
23,401,959 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8451:Vmn1r173
|
UTSW |
7 |
23,401,957 (GRCm39) |
nonsense |
probably null |
|
|
R8923:Vmn1r173
|
UTSW |
7 |
23,401,768 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9126:Vmn1r173
|
UTSW |
7 |
23,402,008 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9506:Vmn1r173
|
UTSW |
7 |
23,401,963 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9557:Vmn1r173
|
UTSW |
7 |
23,402,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Vmn1r173
|
UTSW |
7 |
23,402,012 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Posted On |
2015-04-16 |
Incidental Mutation