Incidental Mutation 'IGL00898:Sectm1b'
ID28473
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sectm1b
Ensembl Gene ENSMUSG00000039364
Gene Namesecreted and transmembrane 1B
SynonymsK12, Sectm1, 1810003C24Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.039) question?
Stock #IGL00898
Quality Score
Status
Chromosome11
Chromosomal Location121053458-121063569 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 121056249 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 17 (W17R)
Ref Sequence ENSEMBL: ENSMUSP00000116010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039309] [ENSMUST00000081499] [ENSMUST00000130786] [ENSMUST00000168459] [ENSMUST00000170381]
Predicted Effect probably damaging
Transcript: ENSMUST00000039309
AA Change: W17R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000045748
Gene: ENSMUSG00000039364
AA Change: W17R

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000081499
AA Change: W17R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000080217
Gene: ENSMUSG00000039364
AA Change: W17R

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000130786
AA Change: W17R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000116010
Gene: ENSMUSG00000039364
AA Change: W17R

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 160 182 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132117
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136500
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150577
Predicted Effect probably damaging
Transcript: ENSMUST00000168459
AA Change: W17R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125965
Gene: ENSMUSG00000039364
AA Change: W17R

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000170381
AA Change: W17R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000126486
Gene: ENSMUSG00000039364
AA Change: W17R

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
IG 40 134 1.81e-1 SMART
transmembrane domain 161 183 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a G A 5: 8,733,690 G956S probably damaging Het
Alpk2 G T 18: 65,350,573 D121E probably benign Het
Apc A G 18: 34,317,094 T2314A probably damaging Het
Arhgef11 T C 3: 87,729,503 L990P probably damaging Het
Ccar1 T A 10: 62,753,234 K823N unknown Het
Celsr2 C T 3: 108,413,879 R539H possibly damaging Het
Clca3b A G 3: 144,844,628 probably benign Het
Cpxcr1 T C X: 116,477,710 L106S possibly damaging Het
Edc4 T A 8: 105,881,123 L16Q probably damaging Het
Emc1 A G 4: 139,371,630 E808G probably damaging Het
Epha6 A T 16: 59,775,541 probably null Het
Epha7 G A 4: 28,938,693 R516Q probably damaging Het
Fancm T C 12: 65,106,000 S1077P probably benign Het
Gm4952 C T 19: 12,618,408 T54I probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Il1b T C 2: 129,367,333 R126G possibly damaging Het
Kin G A 2: 10,080,704 R25H probably damaging Het
Kin T C 2: 10,080,706 W26R probably damaging Het
Lamb3 A T 1: 193,338,883 T923S possibly damaging Het
Lrp6 C T 6: 134,479,739 S854N probably damaging Het
Ltv1 A G 10: 13,182,287 F258L probably damaging Het
Mcm3ap T C 10: 76,470,325 S91P probably benign Het
Msra A G 14: 64,123,325 I125T probably damaging Het
Nr0b1 A T X: 86,192,471 Q224L probably benign Het
Nr2e1 T A 10: 42,568,453 D220V probably damaging Het
Nup160 C A 2: 90,693,106 H351Q probably damaging Het
Olfr1446 T A 19: 12,889,918 M220L probably benign Het
Pcdh12 C A 18: 38,281,457 V872L probably benign Het
Pcnx2 T A 8: 125,887,585 S376C probably damaging Het
Pkd2 A G 5: 104,483,135 E475G probably damaging Het
Psg22 A G 7: 18,724,467 Y322C probably damaging Het
Rgl2 T C 17: 33,933,418 I363T possibly damaging Het
Rimklb G T 6: 122,456,631 Q187K possibly damaging Het
Snu13 C A 15: 82,042,315 A60S probably benign Het
Sox30 T A 11: 45,991,900 F586I possibly damaging Het
Tnfsfm13 C A 11: 69,684,301 V220L probably benign Het
Ttn A T 2: 76,762,773 V20711E probably damaging Het
Vmn2r116 A G 17: 23,385,995 N94S possibly damaging Het
Yipf2 T C 9: 21,592,524 probably null Het
Zzef1 T C 11: 72,875,173 S1509P probably benign Het
Other mutations in Sectm1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Sectm1b APN 11 121055973 missense probably benign 0.02
IGL02071:Sectm1b APN 11 121055935 missense probably damaging 0.96
R0243:Sectm1b UTSW 11 121055785 missense probably damaging 1.00
R1483:Sectm1b UTSW 11 121055826 missense probably benign 0.14
R1862:Sectm1b UTSW 11 121054942 missense possibly damaging 0.92
R4647:Sectm1b UTSW 11 121055934 missense probably damaging 1.00
R5927:Sectm1b UTSW 11 121055674 missense probably benign
R6011:Sectm1b UTSW 11 121055878 missense possibly damaging 0.66
Posted On2013-04-17