Incidental Mutation 'IGL02216:Prl3a1'
ID284903
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl3a1
Ensembl Gene ENSMUSG00000038883
Gene Nameprolactin family 3, subfamily a, member 1
SynonymsPLP-I, 1600016E11Rik, Prlpi, Plpi, PLP-H
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.048) question?
Stock #IGL02216
Quality Score
Status
Chromosome13
Chromosomal Location27259436-27276667 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 27270144 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 35 (D35G)
Ref Sequence ENSEMBL: ENSMUSP00000046522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049463]
Predicted Effect probably benign
Transcript: ENSMUST00000049463
AA Change: D35G

PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000046522
Gene: ENSMUSG00000038883
AA Change: D35G

DomainStartEndE-ValueType
Pfam:Hormone_1 16 227 2.3e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223739
Meta Mutation Damage Score 0.0676 question?
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610009O20Rik A T 18: 38,252,860 I102F probably damaging Het
4930544D05Rik T C 11: 70,616,179 F48L possibly damaging Het
5830473C10Rik T C 5: 90,579,579 probably benign Het
Adamts12 A G 15: 11,241,485 N381S possibly damaging Het
Akp3 A T 1: 87,127,650 Q473L probably damaging Het
Ap5s1 T A 2: 131,212,967 probably benign Het
Atp10b T A 11: 43,259,789 L1438Q probably damaging Het
B3galt4 G A 17: 33,950,565 P233L probably damaging Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cc2d1a C A 8: 84,139,313 E393* probably null Het
Cd209a G T 8: 3,745,576 T165N probably damaging Het
Chid1 T C 7: 141,496,593 probably benign Het
Cln3 A T 7: 126,575,342 probably null Het
Cped1 A T 6: 22,059,945 R203S probably damaging Het
Dnttip2 G T 3: 122,276,261 W375L probably benign Het
Dync1h1 T C 12: 110,663,002 F4280S probably damaging Het
Ephb4 A G 5: 137,372,070 D844G possibly damaging Het
Fhl2 T A 1: 43,131,719 probably null Het
Gne T C 4: 44,044,761 K458E probably benign Het
Grid2 G T 6: 64,345,666 R550L probably damaging Het
Klhl1 T A 14: 96,123,222 T731S probably benign Het
Kng1 T A 16: 23,058,533 D30E probably damaging Het
Kyat1 A G 2: 30,187,252 V158A probably benign Het
Mcm8 G T 2: 132,839,529 V642F probably damaging Het
Mdn1 C T 4: 32,739,092 H3638Y probably benign Het
Neb T G 2: 52,226,490 probably null Het
Neo1 T C 9: 58,917,053 I697M probably damaging Het
Nfkb1 A T 3: 135,594,963 V614D probably damaging Het
Olfr860 G A 9: 19,846,565 S18L probably damaging Het
Otog T C 7: 46,301,468 S2555P probably damaging Het
Pkd1l1 T A 11: 8,834,897 R1962S probably damaging Het
Plxnb1 A G 9: 109,100,850 Y258C probably damaging Het
Pramef8 T A 4: 143,417,728 probably null Het
Rag1 A T 2: 101,643,381 V472D possibly damaging Het
Rbpj-ps3 G A 6: 46,529,707 Het
Rnf112 C T 11: 61,449,978 V472M probably damaging Het
Rps18 A G 17: 33,952,041 probably benign Het
Rptn T C 3: 93,395,773 S138P possibly damaging Het
Sbpl A C 17: 23,953,716 N76K probably benign Het
Sh3bp1 A T 15: 78,905,164 M241L probably benign Het
Slc22a17 T C 14: 54,907,976 *198W probably null Het
Smc3 C T 19: 53,621,844 R221C probably damaging Het
Snai1 A G 2: 167,538,848 E87G probably benign Het
Snx22 C A 9: 66,069,188 A49S probably benign Het
Tas2r143 A T 6: 42,400,334 R33* probably null Het
Try4 A G 6: 41,305,031 I184V probably benign Het
Ttn T A 2: 76,754,552 K20355* probably null Het
Ttn A G 2: 76,791,725 V15491A probably benign Het
Vmn1r170 A G 7: 23,606,490 T106A probably damaging Het
Vmn2r59 A T 7: 42,012,393 V666E probably damaging Het
Vsx1 T C 2: 150,684,575 N221S possibly damaging Het
Zcchc6 T C 13: 59,800,423 T293A probably benign Het
Zfp846 A G 9: 20,588,609 E45G probably damaging Het
Other mutations in Prl3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02648:Prl3a1 APN 13 27270235 missense probably benign 0.00
R1405:Prl3a1 UTSW 13 27275068 intron probably null
R1405:Prl3a1 UTSW 13 27275068 intron probably null
R1596:Prl3a1 UTSW 13 27259617 start gained probably benign
R1823:Prl3a1 UTSW 13 27270194 missense probably damaging 0.99
R1952:Prl3a1 UTSW 13 27270153 missense possibly damaging 0.91
R2059:Prl3a1 UTSW 13 27270144 missense probably benign 0.13
R5843:Prl3a1 UTSW 13 27270110 missense probably damaging 1.00
R6222:Prl3a1 UTSW 13 27276114 missense probably benign 0.05
R6664:Prl3a1 UTSW 13 27270211 nonsense probably null
Posted On2015-04-16