Incidental Mutation 'IGL02217:Gm765'
ID284940
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm765
Ensembl Gene ENSMUSG00000090667
Gene Namepredicted gene 765
SynonymsLOC330390
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL02217
Quality Score
Status
Chromosome6
Chromosomal Location98235708-98342754 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 98248072 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 83 (E83D)
Ref Sequence ENSEMBL: ENSMUSP00000127120 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164491]
Predicted Effect possibly damaging
Transcript: ENSMUST00000164491
AA Change: E83D

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127120
Gene: ENSMUSG00000090667
AA Change: E83D

DomainStartEndE-ValueType
Pfam:MDFI 13 189 1.8e-49 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205146
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik C A 18: 24,470,898 probably benign Het
Actn1 G A 12: 80,174,094 Q647* probably null Het
Adamts6 T A 13: 104,462,365 probably benign Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cabin1 G A 10: 75,700,047 T1389I possibly damaging Het
Cenpc1 A G 5: 86,029,200 probably benign Het
Clca4a T A 3: 144,961,996 T405S possibly damaging Het
Cntln G A 4: 85,100,258 V1168M probably damaging Het
Col18a1 A G 10: 77,053,298 S1494P probably damaging Het
Cps1 A T 1: 67,174,382 T758S probably benign Het
Cul3 A T 1: 80,283,767 M247K probably damaging Het
Cyp3a57 A G 5: 145,369,143 probably null Het
Dennd4c T A 4: 86,813,799 C917S probably benign Het
Dhrs11 A T 11: 84,822,395 Y166* probably null Het
Dtl A G 1: 191,568,314 V146A probably damaging Het
Exosc9 A G 3: 36,552,744 E20G probably damaging Het
Fer A G 17: 64,138,965 K437R probably benign Het
Fkbp6 A T 5: 135,337,630 V284E probably benign Het
Foxq1 A T 13: 31,559,169 S85C probably damaging Het
Galnt12 T A 4: 47,113,832 S83R probably damaging Het
Gm5244 A T 19: 12,846,863 noncoding transcript Het
Gm884 T C 11: 103,612,871 probably benign Het
Gpr156 A G 16: 38,005,311 D630G probably benign Het
Hace1 A T 10: 45,590,375 probably null Het
Hemgn G T 4: 46,396,420 T272K probably damaging Het
Ifi213 T G 1: 173,595,032 E89A possibly damaging Het
Jarid2 A G 13: 44,913,201 E954G probably damaging Het
Kcnu1 A G 8: 25,858,184 D126G probably damaging Het
Lbh A T 17: 72,921,252 I31F possibly damaging Het
Muc6 T C 7: 141,649,624 E490G probably damaging Het
Ncoa3 T C 2: 166,055,346 S686P probably damaging Het
Nme4 A G 17: 26,093,860 M108T probably damaging Het
Nod1 A C 6: 54,943,419 V638G possibly damaging Het
Nrip2 A G 6: 128,406,539 N70S probably damaging Het
Olfr1111 A G 2: 87,149,887 M258T probably benign Het
Olfr1344 T A 7: 6,440,245 I115N probably damaging Het
Pitrm1 G A 13: 6,567,341 probably benign Het
Proser1 A G 3: 53,471,491 K115E probably damaging Het
Ptov1 C T 7: 44,867,476 G70R probably damaging Het
Qtrt1 T G 9: 21,417,389 probably null Het
Rbbp8nl A G 2: 180,278,188 probably benign Het
Rtn3 G A 19: 7,435,084 T794I probably damaging Het
Setd4 A G 16: 93,593,295 L82P probably damaging Het
Shank2 C T 7: 144,285,047 L27F possibly damaging Het
Srpk2 A C 5: 23,545,570 V45G probably damaging Het
Utrn A G 10: 12,751,559 F57S probably damaging Het
Vcan T G 13: 89,703,077 T1255P probably damaging Het
Vmn2r16 A C 5: 109,339,810 H183P probably damaging Het
Wdr48 T C 9: 119,909,535 I286T probably benign Het
Other mutations in Gm765
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02184:Gm765 APN 6 98248098 missense possibly damaging 0.81
R0508:Gm765 UTSW 6 98238044 utr 3 prime probably benign
R1375:Gm765 UTSW 6 98238299 missense possibly damaging 0.77
R1694:Gm765 UTSW 6 98238139 missense probably damaging 0.98
R1944:Gm765 UTSW 6 98248190 missense probably benign 0.01
R4906:Gm765 UTSW 6 98238119 missense probably damaging 1.00
R5472:Gm765 UTSW 6 98238276 missense probably damaging 1.00
R5680:Gm765 UTSW 6 98248226 missense probably damaging 0.99
R6285:Gm765 UTSW 6 98238173 missense probably damaging 1.00
R6692:Gm765 UTSW 6 98248208 missense possibly damaging 0.94
Posted On2015-04-16