Incidental Mutation 'IGL02218:Zfp804a'
ID284978
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp804a
Ensembl Gene ENSMUSG00000070866
Gene Namezinc finger protein 804A
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.211) question?
Stock #IGL02218
Quality Score
Status
Chromosome2
Chromosomal Location82053222-82259879 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 82259202 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Arginine at position 1125 (Q1125R)
Ref Sequence ENSEMBL: ENSMUSP00000041941 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047527]
Predicted Effect probably damaging
Transcript: ENSMUST00000047527
AA Change: Q1125R

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000041941
Gene: ENSMUSG00000070866
AA Change: Q1125R

DomainStartEndE-ValueType
ZnF_C2H2 57 81 7.29e0 SMART
low complexity region 588 595 N/A INTRINSIC
low complexity region 801 808 N/A INTRINSIC
low complexity region 1012 1029 N/A INTRINSIC
low complexity region 1061 1077 N/A INTRINSIC
low complexity region 1168 1191 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127187
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730409E04Rik A G 4: 126,612,045 D122G probably benign Het
Abcc8 T C 7: 46,120,436 D885G probably benign Het
Abcf1 T C 17: 35,958,338 K676R probably benign Het
Acsf2 A G 11: 94,601,763 V3A probably benign Het
Apba2 C T 7: 64,695,677 T205I probably benign Het
Bricd5 C A 17: 24,475,322 Y171* probably null Het
Camk2d T G 3: 126,840,153 N441K probably benign Het
Carm1 T C 9: 21,569,512 V94A probably damaging Het
Chd3 C T 11: 69,352,094 probably benign Het
Cipc A G 12: 86,961,928 N166S probably damaging Het
Cln5 A C 14: 103,075,840 probably null Het
Cnbd1 C A 4: 18,887,739 Q258H probably benign Het
Cyp8b1 A G 9: 121,915,117 L383P probably damaging Het
Dok3 A G 13: 55,523,786 L324P probably damaging Het
Eftud2 A T 11: 102,870,213 F102Y possibly damaging Het
Ewsr1 G A 11: 5,070,668 P551S unknown Het
Fam193a G T 5: 34,443,588 V346L possibly damaging Het
Fam46b C T 4: 133,486,151 A111V probably damaging Het
Golim4 A G 3: 75,878,054 S677P probably damaging Het
Gpr149 A G 3: 62,530,531 probably benign Het
Ins1 A T 19: 52,264,683 K20N probably benign Het
Itpr2 A T 6: 146,240,262 probably benign Het
Jup G A 11: 100,381,839 T249I probably damaging Het
Kctd20 T A 17: 28,957,903 N2K probably benign Het
Kif15 A G 9: 122,995,827 probably benign Het
Klrb1-ps1 T C 6: 129,129,306 noncoding transcript Het
Krtap29-1 T C 11: 99,979,058 probably null Het
Lamb3 A T 1: 193,328,633 probably null Het
Large1 A G 8: 72,912,122 W276R probably damaging Het
Lrp1b T C 2: 41,295,672 N603D probably benign Het
Lrrc37a A G 11: 103,500,381 V1406A probably benign Het
Lrrc74a A G 12: 86,749,048 D265G probably benign Het
Lrrfip2 G A 9: 111,219,725 C250Y probably benign Het
Mbtd1 A G 11: 93,931,803 probably benign Het
Msr1 A G 8: 39,589,316 V406A possibly damaging Het
Mtfr1l C T 4: 134,529,180 D225N probably benign Het
Nckap1l T A 15: 103,483,527 S796R possibly damaging Het
Oaf T A 9: 43,224,922 H119L probably benign Het
Olfr464 A T 11: 87,914,063 M281K probably damaging Het
Pik3c2g A T 6: 139,860,355 H516L probably damaging Het
Pkd1l3 A T 8: 109,660,802 I1793F possibly damaging Het
Ptpra A G 2: 130,552,335 probably benign Het
Slc25a27 C T 17: 43,664,073 probably null Het
Slc2a2 A T 3: 28,698,025 E3D possibly damaging Het
Slc35f5 T C 1: 125,584,555 F14S probably damaging Het
Sspn T C 6: 145,961,386 V105A probably damaging Het
Syvn1 T C 19: 6,050,199 I263T probably damaging Het
Tek A C 4: 94,855,337 D863A probably damaging Het
Tm9sf4 G T 2: 153,204,616 V592F probably benign Het
Tmem259 A G 10: 79,978,317 M354T possibly damaging Het
Ttf2 T C 3: 100,964,093 E84G possibly damaging Het
Ttyh3 T C 5: 140,626,491 E487G probably damaging Het
Ubtf C A 11: 102,306,700 E709* probably null Het
Vmn1r119 T C 7: 21,011,636 R274G probably benign Het
Wdr78 A G 4: 103,096,774 V76A probably damaging Het
Other mutations in Zfp804a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00466:Zfp804a APN 2 82053875 missense probably benign 0.30
IGL02011:Zfp804a APN 2 82256691 missense probably damaging 1.00
IGL02645:Zfp804a APN 2 82053876 missense possibly damaging 0.94
PIT4431001:Zfp804a UTSW 2 82259192 missense probably benign 0.04
R0027:Zfp804a UTSW 2 82257200 missense probably damaging 1.00
R0167:Zfp804a UTSW 2 82256516 missense probably damaging 1.00
R0437:Zfp804a UTSW 2 82053791 start codon destroyed probably null 0.08
R0521:Zfp804a UTSW 2 82259417 nonsense probably null
R0546:Zfp804a UTSW 2 82258920 missense possibly damaging 0.91
R0609:Zfp804a UTSW 2 82257588 missense probably damaging 1.00
R0694:Zfp804a UTSW 2 82053804 missense probably damaging 1.00
R0837:Zfp804a UTSW 2 82259162 missense probably damaging 1.00
R0947:Zfp804a UTSW 2 82258718 missense possibly damaging 0.58
R1103:Zfp804a UTSW 2 82257500 missense probably damaging 0.99
R1168:Zfp804a UTSW 2 82256697 missense probably benign 0.43
R1365:Zfp804a UTSW 2 82257246 missense probably benign 0.00
R1377:Zfp804a UTSW 2 82258497 missense probably benign 0.39
R1501:Zfp804a UTSW 2 82235799 missense probably damaging 1.00
R1526:Zfp804a UTSW 2 82258188 missense probably benign
R1585:Zfp804a UTSW 2 82053751 start gained probably benign
R1674:Zfp804a UTSW 2 82258824 missense probably benign 0.35
R2058:Zfp804a UTSW 2 82257366 missense probably benign 0.00
R2146:Zfp804a UTSW 2 82258664 missense probably benign 0.02
R2149:Zfp804a UTSW 2 82258664 missense probably benign 0.02
R2171:Zfp804a UTSW 2 82257183 missense possibly damaging 0.77
R2307:Zfp804a UTSW 2 82256857 missense probably benign 0.04
R2398:Zfp804a UTSW 2 82258669 missense possibly damaging 0.95
R2496:Zfp804a UTSW 2 82235844 missense probably damaging 1.00
R2504:Zfp804a UTSW 2 82257519 missense probably benign 0.00
R2919:Zfp804a UTSW 2 82235816 missense probably damaging 1.00
R2943:Zfp804a UTSW 2 82235879 missense probably damaging 1.00
R3116:Zfp804a UTSW 2 82259417 missense probably damaging 1.00
R4170:Zfp804a UTSW 2 82253488 missense probably damaging 1.00
R4393:Zfp804a UTSW 2 82256921 missense probably benign 0.43
R4701:Zfp804a UTSW 2 82256582 missense probably damaging 1.00
R4771:Zfp804a UTSW 2 82257942 missense probably benign 0.01
R4793:Zfp804a UTSW 2 82235842 missense probably damaging 1.00
R5523:Zfp804a UTSW 2 82258995 missense probably damaging 1.00
R5526:Zfp804a UTSW 2 82258590 missense probably benign 0.00
R5961:Zfp804a UTSW 2 82258002 missense probably benign
R6181:Zfp804a UTSW 2 82257142 missense probably damaging 1.00
R6209:Zfp804a UTSW 2 82258118 missense probably damaging 1.00
R6325:Zfp804a UTSW 2 82257038 missense possibly damaging 0.80
R7147:Zfp804a UTSW 2 82258187 missense probably benign 0.00
R7229:Zfp804a UTSW 2 82258625 missense probably benign 0.04
X0064:Zfp804a UTSW 2 82235823 missense probably damaging 1.00
Posted On2015-04-16