Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02219:Or9i1'

285042

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or9i1

Ensembl Gene

ENSMUSG00000056858

Gene Name

olfactory receptor family 9 subfamily I member 1

Synonyms

GA_x6K02T2RE5P-4193992-4194942, Olfr1502, MOR211-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.171) question?

Stock #

IGL02219

Quality Score

Status

Chromosome

Chromosomal Location

13839159-13840109 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 13839187 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Methionine at position 10 (T10M)

Ref Sequence

ENSEMBL: ENSMUSP00000073843 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074221]

AlphaFold

Q8VG66

Predicted Effect

probably damaging
Transcript: ENSMUST00000074221
AA Change: T10M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: T10M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	7.1e-43	PFAM
Pfam:7tm_1	41	290	1.6e-17	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A730013G03Rik	A	T	1: 192,515,691 (GRCm39)		noncoding transcript	Het
Abcb10	G	A	8: 124,681,166 (GRCm39)	H677Y	probably benign	Het
Ager	T	C	17: 34,819,094 (GRCm39)	V314A	probably damaging	Het
Asxl3	A	G	18: 22,586,683 (GRCm39)	M158V	possibly damaging	Het
Atp1a2	G	A	1: 172,107,298 (GRCm39)	Q741*	probably null	Het
Atp1a2	A	T	1: 172,107,285 (GRCm39)	M745K	probably damaging	Het
Begain	A	G	12: 108,999,656 (GRCm39)	S577P	probably benign	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Camk2b	A	G	11: 5,926,872 (GRCm39)	L497P	possibly damaging	Het
Cand2	T	A	6: 115,780,773 (GRCm39)	I1219N	probably damaging	Het
Cckbr	T	A	7: 105,083,255 (GRCm39)	Y153N	probably damaging	Het
Cep250	T	G	2: 155,833,514 (GRCm39)	V1812G	probably benign	Het
Cyp2c39	A	T	19: 39,556,643 (GRCm39)		probably benign	Het
Ddx43	T	A	9: 78,324,001 (GRCm39)	M444K	probably damaging	Het
Dnm1	A	T	2: 32,213,462 (GRCm39)	M506K	probably benign	Het
Duox2	A	T	2: 122,125,145 (GRCm39)	H352Q	probably benign	Het
Fcgbpl1	T	C	7: 27,854,060 (GRCm39)	Y1675H	probably damaging	Het
Fsip2	A	G	2: 82,808,174 (GRCm39)	T1498A	probably benign	Het
Gcn1	A	T	5: 115,751,826 (GRCm39)	Q2067L	possibly damaging	Het
Get4	G	T	5: 139,249,384 (GRCm39)		probably null	Het
Gm6370	G	A	5: 146,430,453 (GRCm39)	A213T	possibly damaging	Het
Gpr135	T	C	12: 72,117,047 (GRCm39)	Y240C	probably damaging	Het
Gstm5	T	A	3: 107,805,347 (GRCm39)	L145Q	probably damaging	Het
Hoxb3	T	C	11: 96,236,986 (GRCm39)	Y355H	probably damaging	Het
Hsf2	A	C	10: 57,372,370 (GRCm39)	K108Q	probably damaging	Het
Kdm3a	T	C	6: 71,577,718 (GRCm39)	N694S	probably benign	Het
Lrpap1	G	A	5: 35,253,411 (GRCm39)		probably benign	Het
Mapk8ip3	T	C	17: 25,118,532 (GRCm39)	T1162A	probably damaging	Het
Mettl14	T	C	3: 123,168,540 (GRCm39)		probably benign	Het
Mrgprx1	T	C	7: 47,671,477 (GRCm39)	Y90C	probably benign	Het
Mybpc3	A	T	2: 90,951,368 (GRCm39)		probably null	Het
Nup88	C	T	11: 70,860,518 (GRCm39)	G87D	probably benign	Het
Or5w20	A	G	2: 87,727,317 (GRCm39)	Y258C	possibly damaging	Het
Or7d9	A	T	9: 20,197,756 (GRCm39)	T254S	probably benign	Het
Pan2	G	A	10: 128,156,221 (GRCm39)	E1133K	probably benign	Het
Pcsk2	T	C	2: 143,635,045 (GRCm39)	S307P	probably damaging	Het
Pdgfa	C	T	5: 138,971,950 (GRCm39)	V150I	probably damaging	Het
Phf12	T	C	11: 77,875,022 (GRCm39)	C83R	probably damaging	Het
Pla2g2c	A	G	4: 138,463,319 (GRCm39)	Y71C	probably damaging	Het
Pou2f2	T	A	7: 24,797,107 (GRCm39)	Q218L	probably damaging	Het
Prl8a9	C	T	13: 27,743,353 (GRCm39)	V151I	possibly damaging	Het
Prop1	T	C	11: 50,842,911 (GRCm39)	D92G	probably damaging	Het
Rnf13	A	G	3: 57,703,644 (GRCm39)	Y116C	probably damaging	Het
Ro60	A	G	1: 143,637,013 (GRCm39)	C400R	possibly damaging	Het
Scrib	T	A	15: 75,936,885 (GRCm39)	K383*	probably null	Het
Slc44a5	T	C	3: 153,944,796 (GRCm39)	Y138H	possibly damaging	Het
Stra6	G	A	9: 58,047,752 (GRCm39)	V108M	probably benign	Het
Tspan10	G	T	11: 120,337,198 (GRCm39)	A323S	probably benign	Het
Ttc22	T	A	4: 106,495,687 (GRCm39)	V347D	probably damaging	Het
Ugt1a10	C	T	1: 87,983,780 (GRCm39)	L193F	probably benign	Het
Vps13d	G	T	4: 144,894,716 (GRCm39)	H457N	probably benign	Het
Vrtn	A	G	12: 84,695,607 (GRCm39)	Y119C	probably damaging	Het
Xpnpep3	T	C	15: 81,311,657 (GRCm39)	F121S	probably damaging	Het

Other mutations in Or9i1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Or9i1	APN	19	13,839,150 (GRCm39)	unclassified	probably benign
IGL01061:Or9i1	APN	19	13,840,069 (GRCm39)	missense	possibly damaging	0.94
IGL01534:Or9i1	APN	19	13,839,283 (GRCm39)	missense	probably damaging	1.00
IGL02017:Or9i1	APN	19	13,839,595 (GRCm39)	missense	possibly damaging	0.58
IGL02039:Or9i1	APN	19	13,840,083 (GRCm39)	nonsense	probably null
IGL02173:Or9i1	APN	19	13,839,378 (GRCm39)	missense	probably benign	0.00
IGL02475:Or9i1	APN	19	13,839,663 (GRCm39)	missense	probably damaging	1.00
IGL02604:Or9i1	APN	19	13,839,170 (GRCm39)	missense	probably benign	0.01
R0012:Or9i1	UTSW	19	13,839,187 (GRCm39)	missense	probably damaging	0.98
R0594:Or9i1	UTSW	19	13,839,643 (GRCm39)	missense	probably benign	0.04
R2184:Or9i1	UTSW	19	13,839,399 (GRCm39)	missense	probably benign	0.02
R2518:Or9i1	UTSW	19	13,839,673 (GRCm39)	missense	probably damaging	1.00
R5541:Or9i1	UTSW	19	13,839,328 (GRCm39)	missense	probably benign
R5587:Or9i1	UTSW	19	13,839,940 (GRCm39)	missense	probably damaging	1.00
R6211:Or9i1	UTSW	19	13,839,938 (GRCm39)	missense	probably benign	0.01
R6351:Or9i1	UTSW	19	13,839,186 (GRCm39)	missense	probably benign	0.04
R7575:Or9i1	UTSW	19	13,839,381 (GRCm39)	missense	probably damaging	1.00
R8425:Or9i1	UTSW	19	13,839,849 (GRCm39)	missense	probably benign	0.00
R9545:Or9i1	UTSW	19	13,839,217 (GRCm39)	missense	possibly damaging	0.94

Posted On

2015-04-16