Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00915:Fstl4'

28512

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fstl4

Ensembl Gene

ENSMUSG00000036264

Gene Name

follistatin-like 4

Synonyms

SPIG1, B230374F23Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.137) question?

Stock #

IGL00915

Quality Score

Status

Chromosome

Chromosomal Location

52655461-53079365 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 53067825 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 563 (M563L)

Ref Sequence

ENSEMBL: ENSMUSP00000042007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036796]

AlphaFold

Q5STE3

Predicted Effect

probably benign
Transcript: ENSMUST00000036796
AA Change: M563L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000042007
Gene: ENSMUSG00000036264
AA Change: M563L

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
KAZAL	87	132	4.7e-13	SMART
Blast:IG_like	215	241	6e-7	BLAST
IGc2	260	327	1.9e-6	SMART
IGc2	352	419	1e-14	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice were born at expected Mendelian ratio and healthy, fertile, apparently normal with normal retinal laminar structure. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	T	A	17: 24,593,220 (GRCm39)	Y206N	probably damaging	Het
Aebp2	A	G	6: 140,587,980 (GRCm39)	N350S	probably benign	Het
Cerkl	A	G	2: 79,171,843 (GRCm39)	S367P	probably benign	Het
Ddx60	T	G	8: 62,440,465 (GRCm39)	V1039G	possibly damaging	Het
Fzd9	C	T	5: 135,278,323 (GRCm39)	V521M	probably damaging	Het
Gorab	C	T	1: 163,224,426 (GRCm39)	R125Q	probably benign	Het
Macc1	G	A	12: 119,410,749 (GRCm39)	D506N	probably benign	Het
Mettl17	C	A	14: 52,124,746 (GRCm39)	F119L	probably benign	Het
Nbas	C	A	12: 13,424,753 (GRCm39)	C997*	probably null	Het
Neil1	A	G	9: 57,051,261 (GRCm39)		probably null	Het
Or2r11	A	G	6: 42,437,884 (GRCm39)	I23T	probably benign	Het
Prune2	A	G	19: 16,993,617 (GRCm39)	E185G	probably damaging	Het
Ralgapa2	A	G	2: 146,184,442 (GRCm39)	S1522P	probably damaging	Het
Scd1	A	G	19: 44,388,796 (GRCm39)	L218P	possibly damaging	Het
Setdb1	A	T	3: 95,254,099 (GRCm39)	F234L	probably damaging	Het
Sos1	A	G	17: 80,741,367 (GRCm39)	S473P	probably benign	Het
Spata31d1a	T	C	13: 59,849,999 (GRCm39)	S710G	probably benign	Het
Srp72	C	A	5: 77,126,460 (GRCm39)	C87*	probably null	Het
Tas2r126	T	A	6: 42,412,283 (GRCm39)	I272K	possibly damaging	Het
Trim38	A	T	13: 23,975,015 (GRCm39)	Y318F	possibly damaging	Het
Trnt1	A	G	6: 106,756,387 (GRCm39)	K433E	probably benign	Het
Umodl1	A	G	17: 31,227,724 (GRCm39)		probably benign	Het
Urb1	A	G	16: 90,575,986 (GRCm39)	F857L	possibly damaging	Het
Vps45	A	G	3: 95,953,662 (GRCm39)		probably null	Het
Zfhx4	A	T	3: 5,310,583 (GRCm39)	I989F	probably damaging	Het

Other mutations in Fstl4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00093:Fstl4	APN	11	53,077,102 (GRCm39)	missense	probably benign	0.01
IGL00885:Fstl4	APN	11	53,039,809 (GRCm39)	missense	possibly damaging	0.90
IGL00933:Fstl4	APN	11	53,077,588 (GRCm39)	missense	possibly damaging	0.80
IGL01022:Fstl4	APN	11	53,077,568 (GRCm39)	missense	probably benign	0.18
IGL01121:Fstl4	APN	11	52,705,464 (GRCm39)	missense	probably benign	0.00
IGL01656:Fstl4	APN	11	52,891,201 (GRCm39)	missense	probably damaging	1.00
IGL01805:Fstl4	APN	11	53,077,184 (GRCm39)	missense	probably damaging	1.00
IGL01997:Fstl4	APN	11	53,053,881 (GRCm39)	nonsense	probably null
IGL02386:Fstl4	APN	11	52,664,698 (GRCm39)	missense	probably benign	0.21
IGL02536:Fstl4	APN	11	53,024,851 (GRCm39)	splice site	probably benign
IGL02807:Fstl4	APN	11	53,077,501 (GRCm39)	missense	probably benign	0.03
IGL03037:Fstl4	APN	11	53,059,050 (GRCm39)	missense	possibly damaging	0.83
R0462:Fstl4	UTSW	11	53,077,229 (GRCm39)	missense	probably benign	0.09
R1190:Fstl4	UTSW	11	52,959,373 (GRCm39)	missense	probably benign
R1300:Fstl4	UTSW	11	52,959,454 (GRCm39)	missense	probably benign
R1626:Fstl4	UTSW	11	52,891,117 (GRCm39)	nonsense	probably null
R1695:Fstl4	UTSW	11	53,056,705 (GRCm39)	splice site	probably null
R1699:Fstl4	UTSW	11	53,059,005 (GRCm39)	missense	possibly damaging	0.81
R1727:Fstl4	UTSW	11	52,959,478 (GRCm39)	missense	probably damaging	1.00
R1752:Fstl4	UTSW	11	53,077,622 (GRCm39)	missense	probably benign	0.09
R1866:Fstl4	UTSW	11	53,077,225 (GRCm39)	missense	probably benign	0.00
R4689:Fstl4	UTSW	11	52,959,477 (GRCm39)	nonsense	probably null
R5126:Fstl4	UTSW	11	53,077,388 (GRCm39)	missense	possibly damaging	0.71
R5129:Fstl4	UTSW	11	53,077,266 (GRCm39)	missense	probably damaging	1.00
R5499:Fstl4	UTSW	11	52,959,374 (GRCm39)	missense	probably benign	0.01
R5578:Fstl4	UTSW	11	53,056,608 (GRCm39)	missense	probably damaging	1.00
R5715:Fstl4	UTSW	11	52,891,243 (GRCm39)	missense	possibly damaging	0.53
R6125:Fstl4	UTSW	11	53,077,130 (GRCm39)	missense	probably benign
R6177:Fstl4	UTSW	11	53,059,031 (GRCm39)	missense	probably benign	0.00
R6236:Fstl4	UTSW	11	53,077,162 (GRCm39)	missense	probably benign	0.00
R6311:Fstl4	UTSW	11	53,067,804 (GRCm39)	missense	probably damaging	1.00
R6611:Fstl4	UTSW	11	53,077,552 (GRCm39)	missense	probably benign	0.01
R6886:Fstl4	UTSW	11	53,077,277 (GRCm39)	missense	probably damaging	1.00
R7404:Fstl4	UTSW	11	53,024,898 (GRCm39)	missense	probably benign	0.03
R7423:Fstl4	UTSW	11	52,959,382 (GRCm39)	missense	possibly damaging	0.54
R7586:Fstl4	UTSW	11	52,963,256 (GRCm39)	missense	probably benign	0.00
R7756:Fstl4	UTSW	11	53,059,123 (GRCm39)	missense	possibly damaging	0.69
R7758:Fstl4	UTSW	11	53,059,123 (GRCm39)	missense	possibly damaging	0.69
R7775:Fstl4	UTSW	11	53,067,798 (GRCm39)	nonsense	probably null
R7953:Fstl4	UTSW	11	52,891,050 (GRCm39)	missense	probably benign	0.01
R8026:Fstl4	UTSW	11	52,959,496 (GRCm39)	missense	probably damaging	0.99
R8043:Fstl4	UTSW	11	52,891,050 (GRCm39)	missense	probably benign	0.01
R8375:Fstl4	UTSW	11	53,053,502 (GRCm39)	missense	possibly damaging	0.63
R8866:Fstl4	UTSW	11	52,963,233 (GRCm39)	missense	possibly damaging	0.54
R9103:Fstl4	UTSW	11	52,664,696 (GRCm39)	missense	probably benign	0.21
R9182:Fstl4	UTSW	11	53,024,905 (GRCm39)	missense	probably damaging	0.98
R9297:Fstl4	UTSW	11	53,024,973 (GRCm39)	missense	possibly damaging	0.50
R9390:Fstl4	UTSW	11	52,891,102 (GRCm39)	missense	probably benign
R9396:Fstl4	UTSW	11	52,664,778 (GRCm39)	missense	probably benign
R9447:Fstl4	UTSW	11	53,077,166 (GRCm39)	missense	probably damaging	1.00
R9506:Fstl4	UTSW	11	53,024,950 (GRCm39)	missense	probably benign	0.18
R9518:Fstl4	UTSW	11	53,056,647 (GRCm39)	missense	possibly damaging	0.71
R9523:Fstl4	UTSW	11	53,075,466 (GRCm39)	missense	probably benign	0.04
R9586:Fstl4	UTSW	11	53,077,729 (GRCm39)	missense	probably benign	0.02
R9594:Fstl4	UTSW	11	52,664,694 (GRCm39)	missense	probably benign
X0013:Fstl4	UTSW	11	53,053,446 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-04-17