Incidental Mutation 'IGL02224:Zfp318'
ID 285278
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp318
Ensembl Gene ENSMUSG00000015597
Gene Name zinc finger protein 318
Synonyms 2610034E08Rik, TZF, D530032D06Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02224
Quality Score
Status
Chromosome 17
Chromosomal Location 46694657-46731846 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 46707736 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 265 (R265*)
Ref Sequence ENSEMBL: ENSMUSP00000116544 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113481] [ENSMUST00000138127] [ENSMUST00000152472]
AlphaFold Q99PP2
Predicted Effect probably null
Transcript: ENSMUST00000113481
AA Change: R265*
SMART Domains Protein: ENSMUSP00000109109
Gene: ENSMUSG00000015597
AA Change: R265*

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
low complexity region 30 127 N/A INTRINSIC
low complexity region 150 169 N/A INTRINSIC
low complexity region 208 221 N/A INTRINSIC
low complexity region 291 304 N/A INTRINSIC
coiled coil region 348 376 N/A INTRINSIC
SCOP:d1eq1a_ 916 995 2e-4 SMART
low complexity region 1018 1055 N/A INTRINSIC
ZnF_U1 1085 1119 5.99e-7 SMART
ZnF_C2H2 1088 1112 4.5e1 SMART
ZnF_U1 1155 1189 2.1e-11 SMART
ZnF_C2H2 1158 1180 4.62e1 SMART
low complexity region 1225 1238 N/A INTRINSIC
low complexity region 1358 1371 N/A INTRINSIC
low complexity region 1640 1651 N/A INTRINSIC
Blast:HNHc 1660 1710 3e-17 BLAST
low complexity region 2001 2013 N/A INTRINSIC
low complexity region 2110 2121 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000138127
AA Change: R265*
SMART Domains Protein: ENSMUSP00000116544
Gene: ENSMUSG00000015597
AA Change: R265*

DomainStartEndE-ValueType
low complexity region 3 15 N/A INTRINSIC
low complexity region 30 127 N/A INTRINSIC
low complexity region 150 169 N/A INTRINSIC
low complexity region 208 221 N/A INTRINSIC
low complexity region 291 304 N/A INTRINSIC
coiled coil region 348 376 N/A INTRINSIC
Blast:HOLI 854 1114 8e-19 BLAST
SCOP:d1eq1a_ 916 995 6e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152472
SMART Domains Protein: ENSMUSP00000116132
Gene: ENSMUSG00000015597

DomainStartEndE-ValueType
coiled coil region 3 30 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit reduced male fertility and altered IgM and IgD levels. Null mutants displayed normal level of circulating B cells with decreased IgD and increased IgM levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 T A 13: 4,329,289 (GRCm39) T23S probably damaging Het
Alpk3 G A 7: 80,726,616 (GRCm39) probably benign Het
Atp8b3 A G 10: 80,361,810 (GRCm39) probably benign Het
Atr C T 9: 95,760,682 (GRCm39) R1051C probably damaging Het
B4galt2 T C 4: 117,734,110 (GRCm39) D309G probably benign Het
C130026L21Rik A G 5: 111,730,291 (GRCm39) noncoding transcript Het
Cadm3 A G 1: 173,165,628 (GRCm39) I344T possibly damaging Het
Cd101 T C 3: 100,924,318 (GRCm39) T370A probably benign Het
Col6a5 A T 9: 105,741,534 (GRCm39) S2462T probably damaging Het
Csf3r A T 4: 125,937,332 (GRCm39) N739Y probably benign Het
Ensa T C 3: 95,535,990 (GRCm39) S108P probably benign Het
Fancd2 T A 6: 113,545,281 (GRCm39) probably null Het
Fbp1 T A 13: 63,035,821 (GRCm39) T13S probably damaging Het
Flrt2 C A 12: 95,746,802 (GRCm39) T380K possibly damaging Het
Gpatch11 T C 17: 79,148,522 (GRCm39) probably benign Het
Hagh A G 17: 25,071,861 (GRCm39) D29G probably damaging Het
Hmmr T C 11: 40,600,831 (GRCm39) Q513R unknown Het
Hoxb8 T C 11: 96,173,981 (GRCm39) S65P probably benign Het
Il4ra T C 7: 125,169,271 (GRCm39) probably benign Het
Lbp A G 2: 158,148,669 (GRCm39) N27S probably damaging Het
Msh4 G A 3: 153,595,822 (GRCm39) T76I possibly damaging Het
Nfat5 T C 8: 108,071,447 (GRCm39) V281A probably benign Het
Or10ag53 C T 2: 87,082,821 (GRCm39) S180F probably benign Het
Or13c25 A T 4: 52,911,392 (GRCm39) V134D probably damaging Het
Or4p20 C T 2: 88,254,052 (GRCm39) probably null Het
Or5b106 T A 19: 13,123,120 (GRCm39) K301M probably damaging Het
Or5w16 T A 2: 87,576,757 (GRCm39) C72* probably null Het
Phf11b A T 14: 59,563,515 (GRCm39) probably benign Het
Pik3c2a A G 7: 115,962,575 (GRCm39) probably benign Het
Prdx1 T A 4: 116,549,064 (GRCm39) F66L probably damaging Het
Prss39 A G 1: 34,538,459 (GRCm39) H108R probably damaging Het
Spta1 C A 1: 174,045,255 (GRCm39) probably benign Het
Tmem87b A G 2: 128,676,127 (GRCm39) I297V possibly damaging Het
Vmn1r191 T C 13: 22,363,068 (GRCm39) R229G probably damaging Het
Vmn2r113 A T 17: 23,174,960 (GRCm39) R524* probably null Het
Washc2 T A 6: 116,197,530 (GRCm39) D254E possibly damaging Het
Zfp773 T C 7: 7,135,975 (GRCm39) H207R probably benign Het
Other mutations in Zfp318
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00705:Zfp318 APN 17 46,723,398 (GRCm39) missense probably benign 0.01
IGL00978:Zfp318 APN 17 46,724,652 (GRCm39) missense possibly damaging 0.64
IGL01016:Zfp318 APN 17 46,711,003 (GRCm39) missense probably damaging 1.00
IGL01310:Zfp318 APN 17 46,724,153 (GRCm39) missense possibly damaging 0.81
IGL01453:Zfp318 APN 17 46,719,942 (GRCm39) splice site probably null
IGL01887:Zfp318 APN 17 46,710,094 (GRCm39) missense probably benign 0.07
IGL02025:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02026:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02070:Zfp318 APN 17 46,707,644 (GRCm39) missense probably damaging 1.00
IGL02182:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02187:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02188:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02189:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02190:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02191:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02192:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02203:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02230:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02231:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02232:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02233:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02234:Zfp318 APN 17 46,707,736 (GRCm39) nonsense probably null
IGL02412:Zfp318 APN 17 46,720,043 (GRCm39) nonsense probably null
IGL02792:Zfp318 APN 17 46,720,104 (GRCm39) missense probably damaging 1.00
IGL02826:Zfp318 APN 17 46,709,680 (GRCm39) missense probably damaging 1.00
Wonton UTSW 17 46,720,618 (GRCm39) missense possibly damaging 0.89
I0000:Zfp318 UTSW 17 46,710,485 (GRCm39) missense probably damaging 1.00
R0206:Zfp318 UTSW 17 46,709,945 (GRCm39) missense probably benign 0.07
R0240:Zfp318 UTSW 17 46,707,739 (GRCm39) missense probably benign 0.00
R0240:Zfp318 UTSW 17 46,707,739 (GRCm39) missense probably benign 0.00
R0281:Zfp318 UTSW 17 46,723,540 (GRCm39) missense probably benign 0.05
R0350:Zfp318 UTSW 17 46,724,124 (GRCm39) missense probably benign 0.00
R0383:Zfp318 UTSW 17 46,724,222 (GRCm39) missense probably damaging 0.99
R0453:Zfp318 UTSW 17 46,707,634 (GRCm39) missense probably damaging 0.96
R1014:Zfp318 UTSW 17 46,723,462 (GRCm39) nonsense probably null
R1166:Zfp318 UTSW 17 46,720,618 (GRCm39) missense possibly damaging 0.89
R1208:Zfp318 UTSW 17 46,723,446 (GRCm39) unclassified probably benign
R1208:Zfp318 UTSW 17 46,723,446 (GRCm39) unclassified probably benign
R1327:Zfp318 UTSW 17 46,724,189 (GRCm39) missense probably damaging 1.00
R1330:Zfp318 UTSW 17 46,724,684 (GRCm39) missense possibly damaging 0.90
R1737:Zfp318 UTSW 17 46,710,403 (GRCm39) missense probably benign 0.35
R1800:Zfp318 UTSW 17 46,722,980 (GRCm39) missense probably benign 0.00
R1846:Zfp318 UTSW 17 46,724,592 (GRCm39) missense probably benign 0.00
R1848:Zfp318 UTSW 17 46,716,981 (GRCm39) missense possibly damaging 0.92
R1861:Zfp318 UTSW 17 46,722,366 (GRCm39) missense possibly damaging 0.92
R1913:Zfp318 UTSW 17 46,723,450 (GRCm39) unclassified probably benign
R1913:Zfp318 UTSW 17 46,723,440 (GRCm39) unclassified probably benign
R2059:Zfp318 UTSW 17 46,707,950 (GRCm39) missense probably damaging 0.99
R2085:Zfp318 UTSW 17 46,720,590 (GRCm39) splice site probably null
R2122:Zfp318 UTSW 17 46,724,297 (GRCm39) missense probably benign 0.01
R2339:Zfp318 UTSW 17 46,710,389 (GRCm39) missense probably benign 0.01
R4526:Zfp318 UTSW 17 46,723,284 (GRCm39) missense probably benign 0.00
R4564:Zfp318 UTSW 17 46,723,741 (GRCm39) missense possibly damaging 0.77
R4689:Zfp318 UTSW 17 46,710,560 (GRCm39) missense probably damaging 0.99
R4795:Zfp318 UTSW 17 46,722,988 (GRCm39) missense probably benign 0.07
R5256:Zfp318 UTSW 17 46,722,995 (GRCm39) missense probably benign 0.19
R5317:Zfp318 UTSW 17 46,723,463 (GRCm39) unclassified probably benign
R5323:Zfp318 UTSW 17 46,697,662 (GRCm39) missense probably damaging 0.99
R5436:Zfp318 UTSW 17 46,723,975 (GRCm39) missense possibly damaging 0.95
R5485:Zfp318 UTSW 17 46,723,180 (GRCm39) missense possibly damaging 0.81
R5627:Zfp318 UTSW 17 46,724,062 (GRCm39) missense probably damaging 1.00
R5643:Zfp318 UTSW 17 46,720,170 (GRCm39) intron probably benign
R5782:Zfp318 UTSW 17 46,723,440 (GRCm39) unclassified probably benign
R5783:Zfp318 UTSW 17 46,723,440 (GRCm39) unclassified probably benign
R5820:Zfp318 UTSW 17 46,723,699 (GRCm39) missense probably benign
R5895:Zfp318 UTSW 17 46,709,959 (GRCm39) missense probably damaging 1.00
R6189:Zfp318 UTSW 17 46,723,440 (GRCm39) unclassified probably benign
R6385:Zfp318 UTSW 17 46,721,932 (GRCm39) missense probably damaging 1.00
R6428:Zfp318 UTSW 17 46,710,262 (GRCm39) missense probably damaging 1.00
R6471:Zfp318 UTSW 17 46,710,431 (GRCm39) missense probably benign 0.05
R6666:Zfp318 UTSW 17 46,720,140 (GRCm39) missense probably benign 0.01
R6812:Zfp318 UTSW 17 46,723,468 (GRCm39) unclassified probably benign
R6852:Zfp318 UTSW 17 46,723,464 (GRCm39) unclassified probably benign
R6852:Zfp318 UTSW 17 46,723,459 (GRCm39) unclassified probably benign
R6852:Zfp318 UTSW 17 46,723,460 (GRCm39) unclassified probably benign
R6854:Zfp318 UTSW 17 46,723,468 (GRCm39) unclassified probably benign
R6980:Zfp318 UTSW 17 46,708,138 (GRCm39) missense probably damaging 1.00
R6999:Zfp318 UTSW 17 46,710,969 (GRCm39) missense probably damaging 1.00
R7164:Zfp318 UTSW 17 46,716,865 (GRCm39) missense probably damaging 1.00
R7164:Zfp318 UTSW 17 46,708,232 (GRCm39) critical splice donor site probably null
R7175:Zfp318 UTSW 17 46,697,774 (GRCm39) missense probably damaging 1.00
R7233:Zfp318 UTSW 17 46,716,978 (GRCm39) missense probably damaging 0.99
R7339:Zfp318 UTSW 17 46,722,173 (GRCm39) missense probably damaging 0.99
R7426:Zfp318 UTSW 17 46,710,995 (GRCm39) missense probably damaging 1.00
R7600:Zfp318 UTSW 17 46,695,210 (GRCm39) missense possibly damaging 0.86
R7608:Zfp318 UTSW 17 46,710,935 (GRCm39) missense probably damaging 0.96
R7779:Zfp318 UTSW 17 46,710,820 (GRCm39) missense probably benign 0.16
R8057:Zfp318 UTSW 17 46,710,692 (GRCm39) missense possibly damaging 0.72
R8273:Zfp318 UTSW 17 46,723,301 (GRCm39) missense probably damaging 1.00
R8274:Zfp318 UTSW 17 46,723,915 (GRCm39) missense probably benign
R8695:Zfp318 UTSW 17 46,723,576 (GRCm39) missense probably benign 0.01
R8822:Zfp318 UTSW 17 46,723,831 (GRCm39) missense probably benign 0.00
R8851:Zfp318 UTSW 17 46,710,761 (GRCm39) missense probably damaging 1.00
R8913:Zfp318 UTSW 17 46,722,699 (GRCm39) missense probably benign 0.07
R8953:Zfp318 UTSW 17 46,731,356 (GRCm39) missense probably benign 0.38
R9031:Zfp318 UTSW 17 46,723,433 (GRCm39) missense probably benign 0.15
R9327:Zfp318 UTSW 17 46,721,892 (GRCm39) missense probably damaging 1.00
R9329:Zfp318 UTSW 17 46,722,139 (GRCm39) missense probably damaging 1.00
R9352:Zfp318 UTSW 17 46,721,284 (GRCm39) missense probably damaging 1.00
R9633:Zfp318 UTSW 17 46,710,421 (GRCm39) missense probably damaging 0.99
R9662:Zfp318 UTSW 17 46,724,383 (GRCm39) missense probably damaging 1.00
R9728:Zfp318 UTSW 17 46,707,713 (GRCm39) missense probably benign 0.10
R9755:Zfp318 UTSW 17 46,722,055 (GRCm39) missense probably damaging 1.00
X0026:Zfp318 UTSW 17 46,721,564 (GRCm39) missense possibly damaging 0.89
X0054:Zfp318 UTSW 17 46,723,535 (GRCm39) missense possibly damaging 0.79
X0065:Zfp318 UTSW 17 46,721,915 (GRCm39) missense probably benign 0.01
Z1176:Zfp318 UTSW 17 46,716,904 (GRCm39) missense probably benign 0.03
Posted On 2015-04-16