Incidental Mutation 'IGL02225:Olfr1137'
ID285315
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1137
Ensembl Gene ENSMUSG00000075150
Gene Nameolfactory receptor 1137
SynonymsGA_x6K02T2Q125-49215724-49214792, MOR40-9P, MOR177-20
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL02225
Quality Score
Status
Chromosome2
Chromosomal Location87708873-87713179 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 87711399 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Tyrosine at position 169 (C169Y)
Ref Sequence ENSEMBL: ENSMUSP00000149311 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099850] [ENSMUST00000214209]
Predicted Effect possibly damaging
Transcript: ENSMUST00000099850
AA Change: C169Y

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000097437
Gene: ENSMUSG00000075150
AA Change: C169Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.3e-45 PFAM
Pfam:7tm_1 41 290 2.8e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214209
AA Change: C169Y

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp4 A G 7: 44,256,741 probably null Het
Adgrf4 C A 17: 42,663,378 probably null Het
Aqp9 A T 9: 71,130,547 probably benign Het
C1s1 A G 6: 124,541,334 W8R probably benign Het
Cfap43 A G 19: 47,812,177 I345T probably benign Het
Cwh43 T C 5: 73,421,567 Y306H probably damaging Het
Cyp4a32 A T 4: 115,610,503 H228L probably benign Het
Ddx24 A G 12: 103,417,371 L607P probably damaging Het
Dlg3 A G X: 100,807,188 K232R probably benign Het
Fgfr1op T G 17: 8,182,419 D257E probably damaging Het
Fig4 A G 10: 41,256,452 S453P probably benign Het
Frem1 A G 4: 82,940,506 L1556P probably damaging Het
Gjb2 T C 14: 57,100,188 K188E probably damaging Het
Gp1bb C A 16: 18,620,900 W148L possibly damaging Het
Grip1 C T 10: 120,049,453 T375M probably damaging Het
Hnf1b T C 11: 83,861,785 L82P probably damaging Het
Jakmip1 T C 5: 37,104,856 V333A probably damaging Het
Magi1 G T 6: 93,694,026 R1069S probably damaging Het
Myh15 A T 16: 49,091,163 E319D probably benign Het
Myl4 A G 11: 104,580,402 I42V probably benign Het
Obsl1 A T 1: 75,503,798 V394E probably damaging Het
Olfr376 T A 11: 73,375,078 F110I probably damaging Het
Olfr598 A T 7: 103,329,166 I227F probably damaging Het
Pcnt C T 10: 76,389,474 R1732K probably benign Het
Pkd1l3 T C 8: 109,638,678 Y1144H probably damaging Het
Pogz A G 3: 94,879,016 K972E probably damaging Het
Sccpdh A G 1: 179,679,699 T227A probably benign Het
Sec16b A G 1: 157,532,044 probably benign Het
Slain2 T A 5: 72,941,390 V163E probably damaging Het
Snx1 G A 9: 66,109,621 P56L probably benign Het
Snx14 G A 9: 88,413,524 T196I probably damaging Het
Sspo T C 6: 48,484,334 F3570L probably benign Het
Tbrg4 C A 11: 6,624,094 V43F probably damaging Het
Traf3ip3 A G 1: 193,195,100 I176T probably benign Het
Trbv20 T A 6: 41,188,307 probably benign Het
Ubc A T 5: 125,386,133 V710D probably benign Het
Ugt2b35 T C 5: 87,007,405 probably benign Het
Zbed5 C T 5: 129,902,133 probably null Het
Zc3hav1 T C 6: 38,340,341 Y108C probably damaging Het
Other mutations in Olfr1137
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Olfr1137 APN 2 87711133 missense possibly damaging 0.76
IGL02312:Olfr1137 APN 2 87711009 missense probably benign 0.00
IGL03326:Olfr1137 APN 2 87711695 missense probably damaging 1.00
R0432:Olfr1137 UTSW 2 87711430 missense probably benign 0.13
R1656:Olfr1137 UTSW 2 87711078 missense possibly damaging 0.94
R1852:Olfr1137 UTSW 2 87710973 splice site probably null
R1880:Olfr1137 UTSW 2 87711295 missense probably damaging 1.00
R2184:Olfr1137 UTSW 2 87711205 missense probably damaging 1.00
R2511:Olfr1137 UTSW 2 87711048 missense probably damaging 1.00
R4356:Olfr1137 UTSW 2 87711885 missense possibly damaging 0.95
R6184:Olfr1137 UTSW 2 87711844 missense probably benign
R6278:Olfr1137 UTSW 2 87711471 nonsense probably null
R6621:Olfr1137 UTSW 2 87711555 missense probably benign 0.10
R7549:Olfr1137 UTSW 2 87711771 missense probably damaging 1.00
Posted On2015-04-16