Incidental Mutation 'IGL02229:Iglc2'
ID285426
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iglc2
Ensembl Gene ENSMUSG00000076937
Gene Nameimmunoglobulin lambda constant 2
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL02229
Quality Score
Status
Chromosome16
Chromosomal Location19198536-19198852 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 19198733 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 41 (A41T)
Ref Sequence ENSEMBL: ENSMUSP00000143153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103749] [ENSMUST00000198182]
Predicted Effect probably benign
Transcript: ENSMUST00000103749
AA Change: A40T

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000100464
Gene: ENSMUSG00000076937
AA Change: A40T

DomainStartEndE-ValueType
IGc1 22 95 4.47e-33 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000197046
Predicted Effect probably benign
Transcript: ENSMUST00000197969
Predicted Effect probably benign
Transcript: ENSMUST00000198182
AA Change: A41T

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000143153
Gene: ENSMUSG00000076937
AA Change: A41T

DomainStartEndE-ValueType
IGc1 23 96 1.8e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198313
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik A G 5: 63,898,353 D144G probably damaging Het
Adgrg1 G T 8: 95,003,511 D114Y probably damaging Het
Ago4 T A 4: 126,511,532 N416I probably benign Het
Aoc1 C T 6: 48,905,909 Q240* probably null Het
Atl1 G A 12: 69,926,025 V40I probably benign Het
Cdh2 T C 18: 16,624,753 I591V probably benign Het
Cic C A 7: 25,290,950 Q1959K probably damaging Het
Cmya5 C T 13: 93,092,686 E1965K possibly damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cspp1 T C 1: 10,083,556 S397P probably damaging Het
D130043K22Rik T C 13: 24,875,924 Y593H probably damaging Het
Dck A G 5: 88,774,105 Y142C probably damaging Het
Eea1 A T 10: 96,018,184 E568V probably damaging Het
Gabra3 A G X: 72,501,077 probably null Het
Gucy2f A G X: 142,179,988 S342P probably benign Het
Hbb-bh1 T A 7: 103,842,825 I61F possibly damaging Het
Hook1 T C 4: 96,001,251 S235P possibly damaging Het
Hoxd12 G A 2: 74,675,934 R230H probably damaging Het
Il1r1 A G 1: 40,313,358 K566E probably damaging Het
Kcns3 A T 12: 11,092,092 M202K probably damaging Het
Krt7 C A 15: 101,427,616 A442D probably benign Het
Ltk C T 2: 119,758,573 R200H probably benign Het
Macf1 G T 4: 123,509,826 D582E probably damaging Het
Mbnl3 A T X: 51,139,341 Y69N probably damaging Het
Mpp1 T C X: 75,121,428 probably benign Het
Myo18b A G 5: 112,878,110 S25P unknown Het
Nsd3 A G 8: 25,710,748 N1289S probably damaging Het
Olfr26 T A 9: 38,855,416 M118K possibly damaging Het
Pacs2 A G 12: 113,056,800 probably benign Het
Rab3gap2 A G 1: 185,259,383 K689E possibly damaging Het
Sva T A 6: 42,042,222 C109S probably damaging Het
Taf3 T C 2: 9,952,834 N174S probably damaging Het
Tbc1d5 A T 17: 50,852,600 M393K probably damaging Het
Tmem242 A T 17: 5,411,407 S129T probably benign Het
Ttn A T 2: 76,871,169 probably benign Het
Other mutations in Iglc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02125:Iglc2 APN 16 19198712 missense probably benign 0.03
IGL02264:Iglc2 APN 16 19198647 missense probably damaging 1.00
R0674:Iglc2 UTSW 16 19198841 missense probably benign 0.29
R5709:Iglc2 UTSW 16 19198634 missense probably benign 0.39
Posted On2015-04-16