Incidental Mutation 'IGL02212:Mup21'
ID285505
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mup21
Ensembl Gene ENSMUSG00000066153
Gene Namemajor urinary protein 21
SynonymsGm11208
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02212
Quality Score
Status
Chromosome4
Chromosomal Location62147932-62150863 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 62148592 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Alanine at position 137 (E137A)
Ref Sequence ENSEMBL: ENSMUSP00000076899 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077719]
Predicted Effect probably damaging
Transcript: ENSMUST00000077719
AA Change: E137A

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000076899
Gene: ENSMUSG00000066153
AA Change: E137A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Lipocalin 35 174 3.9e-37 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T A 2: 69,248,889 D1079V probably damaging Het
Adam18 T C 8: 24,637,179 H467R probably benign Het
Ambra1 T G 2: 91,917,361 D1056E probably damaging Het
Aoah A C 13: 21,002,901 N456T probably benign Het
Batf2 T A 19: 6,171,961 F267Y probably damaging Het
Bbs7 C T 3: 36,594,409 V397I probably benign Het
Bbs9 T A 9: 22,812,512 D824E probably benign Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Brip1 A T 11: 86,139,015 V601E possibly damaging Het
Bub1 A G 2: 127,805,351 F773L probably damaging Het
Cadps A T 14: 12,522,345 D606E possibly damaging Het
Cenps T G 4: 149,128,846 D54A probably damaging Het
Cep170 T A 1: 176,735,936 N1504I probably damaging Het
Cttnbp2 A G 6: 18,382,749 V1340A possibly damaging Het
D630003M21Rik A T 2: 158,210,171 S667T probably benign Het
Dgkb A G 12: 38,139,414 Y272C probably damaging Het
Dlx3 A G 11: 95,120,641 D107G probably benign Het
Drd3 A T 16: 43,762,312 N56I probably benign Het
Elavl4 T A 4: 110,206,412 I331F probably damaging Het
Fam167a T G 14: 63,462,629 S213A probably damaging Het
Fasn A T 11: 120,807,903 I2489N probably damaging Het
Fbxo43 T C 15: 36,151,811 K587E probably damaging Het
Fscn2 A G 11: 120,362,055 D116G probably damaging Het
Galm T C 17: 80,150,117 V194A probably benign Het
Gm14851 C T 8: 21,095,260 probably benign Het
Gpr180 T A 14: 118,160,176 F361I probably damaging Het
Gpx2 A T 12: 76,792,908 C105* probably null Het
Gsdmc2 A T 15: 63,828,062 probably benign Het
Hes2 T G 4: 152,160,525 S150R probably damaging Het
Ighv1-56 C T 12: 115,242,797 probably benign Het
Inhbb A T 1: 119,417,983 V192D probably benign Het
Itgal A T 7: 127,300,980 M137L probably benign Het
Jak2 A G 19: 29,287,982 N470D probably benign Het
Jph1 T C 1: 17,091,757 E227G probably damaging Het
Kcnj6 A T 16: 94,832,487 I237N probably damaging Het
Kctd8 G T 5: 69,340,688 P205Q probably benign Het
Klhdc1 A T 12: 69,250,766 N37I probably damaging Het
Lrp2 T A 2: 69,451,264 H3921L probably benign Het
Lrp8os2 T C 4: 107,807,048 probably benign Het
Man2a2 A C 7: 80,362,308 D700E probably benign Het
Mast1 A T 8: 84,921,397 L485Q probably damaging Het
Mmp3 A G 9: 7,450,165 D299G probably damaging Het
Mptx2 T A 1: 173,274,681 D147V possibly damaging Het
Mrpl9 T A 3: 94,443,817 probably null Het
Mutyh T A 4: 116,815,606 V52D probably damaging Het
Nalcn T A 14: 123,515,330 S340C probably damaging Het
Neb A G 2: 52,308,311 Y474H probably damaging Het
Nol8 A G 13: 49,662,150 E560G possibly damaging Het
Ntn4 A G 10: 93,644,849 D145G possibly damaging Het
Nup93 G A 8: 94,311,662 probably null Het
Olfr133 C A 17: 38,148,855 T89K probably benign Het
Olfr1384 A T 11: 49,513,910 I91F probably damaging Het
Olfr346 A G 2: 36,688,182 Y60C probably damaging Het
Olfr691 C T 7: 105,337,143 C191Y probably damaging Het
Pcdhb8 T A 18: 37,356,412 V40E possibly damaging Het
Peg3 C T 7: 6,711,416 R269H probably benign Het
Piwil1 T A 5: 128,750,270 F648I possibly damaging Het
Psd4 A T 2: 24,405,314 K827* probably null Het
Retsat T A 6: 72,601,710 L135* probably null Het
Rtp3 A G 9: 110,987,321 probably benign Het
Samd14 A G 11: 95,023,350 Y305C probably damaging Het
Satb1 T A 17: 51,775,291 Q445L possibly damaging Het
Shbg A G 11: 69,617,209 L110P probably damaging Het
Slc17a6 T A 7: 51,667,470 I413N possibly damaging Het
Slu7 A T 11: 43,440,642 Q201L probably benign Het
Spg11 T C 2: 122,108,157 T439A probably benign Het
Sstr5 A T 17: 25,491,673 L194Q possibly damaging Het
Tjp2 A T 19: 24,138,786 L13Q probably damaging Het
Tnk2 G A 16: 32,680,142 V758I probably damaging Het
Ttll8 C A 15: 88,917,247 V413L probably benign Het
Wiz T C 17: 32,368,135 D67G probably damaging Het
Other mutations in Mup21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03158:Mup21 APN 4 62150288 missense probably benign 0.08
FR4548:Mup21 UTSW 4 62149345 critical splice donor site probably benign
FR4548:Mup21 UTSW 4 62149346 critical splice donor site probably benign
FR4976:Mup21 UTSW 4 62149350 critical splice donor site probably benign
R0669:Mup21 UTSW 4 62150727 missense unknown
R0795:Mup21 UTSW 4 62148241 nonsense probably null
R0797:Mup21 UTSW 4 62148241 nonsense probably null
R0802:Mup21 UTSW 4 62148241 nonsense probably null
R0803:Mup21 UTSW 4 62148241 nonsense probably null
R0805:Mup21 UTSW 4 62148241 nonsense probably null
R0808:Mup21 UTSW 4 62148241 nonsense probably null
R0810:Mup21 UTSW 4 62148241 nonsense probably null
R0845:Mup21 UTSW 4 62150310 missense probably damaging 1.00
R1288:Mup21 UTSW 4 62150697 missense probably benign 0.03
R1876:Mup21 UTSW 4 62149426 missense probably benign 0.05
R4923:Mup21 UTSW 4 62147965 missense probably benign 0.00
R5713:Mup21 UTSW 4 62150274 missense probably damaging 0.99
R7312:Mup21 UTSW 4 62150231 missense probably benign 0.15
X0022:Mup21 UTSW 4 62150243 missense probably damaging 1.00
Posted On2015-04-16