Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02227:Or5p1'

285607

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p1

Ensembl Gene

ENSMUSG00000094612

Gene Name

olfactory receptor family 5 subfamily P member 1

Synonyms

MOR204-11, GA_x6K02T2PBJ9-10646917-10647849, Olfr491

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

IGL02227

Quality Score

Status

Chromosome

Chromosomal Location

107916103-107917035 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 107916408 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 102 (C102*)

Ref Sequence

ENSEMBL: ENSMUSP00000150694 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053179] [ENSMUST00000209545] [ENSMUST00000214605]

AlphaFold

Q8VG06

Predicted Effect

probably null
Transcript: ENSMUST00000053179
AA Change: C102*

SMART Domains

Protein: ENSMUSP00000061188
Gene: ENSMUSG00000094612
AA Change: C102*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	3.4e-50	PFAM
Pfam:7tm_1	41	290	5.4e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000209545
AA Change: C102*

Predicted Effect

probably null
Transcript: ENSMUST00000214605
AA Change: C102*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl1	A	G	8: 46,987,402 (GRCm39)	E662G	probably benign	Het
Acss3	A	G	10: 106,881,196 (GRCm39)	S262P	probably benign	Het
Agap1	T	C	1: 89,591,497 (GRCm39)	V263A	probably damaging	Het
Ap3b2	A	G	7: 81,123,152 (GRCm39)	L454P	probably damaging	Het
Arrdc1	A	T	2: 24,816,164 (GRCm39)	F280I	possibly damaging	Het
Atp8b1	G	T	18: 64,695,261 (GRCm39)	H485N	probably benign	Het
Atrip	A	G	9: 108,890,732 (GRCm39)	S91P	possibly damaging	Het
Bcorl1	T	C	X: 47,458,237 (GRCm39)	V590A	probably benign	Het
Brf1	C	A	12: 112,925,394 (GRCm39)	R590S	probably damaging	Het
Ccdc18	A	T	5: 108,296,788 (GRCm39)	D197V	possibly damaging	Het
Ccr6	T	C	17: 8,475,284 (GRCm39)	V163A	probably damaging	Het
Cct6b	T	C	11: 82,632,217 (GRCm39)	E257G	probably damaging	Het
Cdc42bpa	A	G	1: 179,921,989 (GRCm39)	D564G	possibly damaging	Het
Cdh2	C	T	18: 16,762,643 (GRCm39)	V434I	probably benign	Het
Cfap410	A	G	10: 77,818,784 (GRCm39)	N152D	possibly damaging	Het
Cltc	C	T	11: 86,588,166 (GRCm39)	V1610M	possibly damaging	Het
Cnot4	A	G	6: 35,028,198 (GRCm39)	F473L	probably benign	Het
Dock3	T	C	9: 106,939,254 (GRCm39)	K165E	probably damaging	Het
Duox2	A	T	2: 122,115,634 (GRCm39)		probably benign	Het
Epha7	A	G	4: 28,821,587 (GRCm39)	S251G	possibly damaging	Het
Epn1	T	A	7: 5,098,035 (GRCm39)	V282E	probably benign	Het
Fat1	T	C	8: 45,476,696 (GRCm39)	L1914P	probably damaging	Het
Fbln2	T	C	6: 91,233,349 (GRCm39)	I611T	possibly damaging	Het
Fgd6	G	T	10: 93,969,946 (GRCm39)	M1198I	probably damaging	Het
Frmpd4	T	A	X: 166,275,931 (GRCm39)	I379F	probably damaging	Het
Grk4	T	A	5: 34,852,126 (GRCm39)	D123E	probably benign	Het
Hc	T	G	2: 34,899,923 (GRCm39)		probably benign	Het
Hephl1	T	C	9: 14,981,089 (GRCm39)	Y781C	probably damaging	Het
Hfe	T	C	13: 23,890,926 (GRCm39)	E71G	probably benign	Het
Hk1	A	G	10: 62,116,919 (GRCm39)		probably benign	Het
Ifnk	G	A	4: 35,152,642 (GRCm39)		probably benign	Het
Kcnv1	C	A	15: 44,977,670 (GRCm39)	G123C	probably damaging	Het
Klhl38	A	T	15: 58,186,633 (GRCm39)	I32N	possibly damaging	Het
Lpl	T	C	8: 69,348,452 (GRCm39)	V227A	probably damaging	Het
Lurap1l	A	T	4: 80,872,094 (GRCm39)	S196C	probably damaging	Het
Mta1	T	C	12: 113,084,528 (GRCm39)	L91P	possibly damaging	Het
Nelfe	C	A	17: 35,073,330 (GRCm39)	D288E	probably benign	Het
Otof	T	C	5: 30,528,128 (GRCm39)	E1905G	probably damaging	Het
Pck2	T	C	14: 55,781,323 (GRCm39)	I148T	probably benign	Het
Plcl2	G	T	17: 50,913,425 (GRCm39)	V145F	probably damaging	Het
Plec	A	G	15: 76,056,474 (GRCm39)	S4510P	probably damaging	Het
Plxna2	A	G	1: 194,434,397 (GRCm39)	E641G	probably damaging	Het
Poglut3	T	C	9: 53,299,779 (GRCm39)	L96S	probably damaging	Het
Ppp1r12a	C	T	10: 108,105,185 (GRCm39)	T434M	probably damaging	Het
Ppp6r3	A	T	19: 3,568,245 (GRCm39)	N184K	possibly damaging	Het
Prkar1a	G	A	11: 109,551,001 (GRCm39)		probably benign	Het
Psmb1	A	T	17: 15,710,546 (GRCm39)	M1K	probably null	Het
Pwwp2a	T	C	11: 43,596,448 (GRCm39)	S538P	possibly damaging	Het
Rbm25	C	T	12: 83,719,527 (GRCm39)	R516W	probably damaging	Het
Rnf103	A	G	6: 71,487,172 (GRCm39)	D601G	probably benign	Het
Senp3	A	G	11: 69,565,356 (GRCm39)	V467A	possibly damaging	Het
Slc8a3	T	G	12: 81,362,457 (GRCm39)	T121P	probably damaging	Het
Slco1a8	A	T	6: 141,939,401 (GRCm39)	C197*	probably null	Het
Srrt	G	A	5: 137,294,536 (GRCm39)	T790M	probably damaging	Het
Ssc5d	T	C	7: 4,936,453 (GRCm39)		probably null	Het
Tas2r129	G	A	6: 132,928,357 (GRCm39)	W98*	probably null	Het
Thoc5	A	C	11: 4,876,217 (GRCm39)	M609L	probably benign	Het
Tnip1	G	A	11: 54,827,297 (GRCm39)	T155M	possibly damaging	Het
Ttn	A	G	2: 76,618,672 (GRCm39)	V14458A	probably benign	Het
Unc5cl	A	G	17: 48,766,809 (GRCm39)	E61G	probably benign	Het
Usp32	T	C	11: 84,877,307 (GRCm39)	K151E	probably damaging	Het
Vmn2r121	T	C	X: 123,042,378 (GRCm39)	M260V	probably benign	Het
Vwa7	G	T	17: 35,239,060 (GRCm39)	R345L	probably damaging	Het
Zfp366	G	T	13: 99,370,696 (GRCm39)	R472L	possibly damaging	Het
Zfp811	A	T	17: 33,017,616 (GRCm39)	Y141*	probably null	Het
Zpbp	C	T	11: 11,365,248 (GRCm39)	E200K	probably benign	Het

Other mutations in Or5p1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01672:Or5p1	APN	7	107,916,725 (GRCm39)	missense	probably benign	0.02
IGL01731:Or5p1	APN	7	107,916,682 (GRCm39)	missense	probably benign	0.01
IGL02624:Or5p1	APN	7	107,916,130 (GRCm39)	missense	probably benign	0.38
IGL03164:Or5p1	APN	7	107,916,901 (GRCm39)	missense	probably damaging	1.00
R0143:Or5p1	UTSW	7	107,916,202 (GRCm39)	missense	probably benign	0.00
R0217:Or5p1	UTSW	7	107,916,505 (GRCm39)	missense	probably benign	0.00
R0295:Or5p1	UTSW	7	107,916,892 (GRCm39)	missense	probably benign	0.42
R2100:Or5p1	UTSW	7	107,916,761 (GRCm39)	missense	probably benign	0.04
R2379:Or5p1	UTSW	7	107,916,499 (GRCm39)	missense	probably benign	0.25
R4178:Or5p1	UTSW	7	107,916,565 (GRCm39)	missense	probably damaging	1.00
R4365:Or5p1	UTSW	7	107,916,313 (GRCm39)	missense	probably benign	0.02
R4734:Or5p1	UTSW	7	107,916,959 (GRCm39)	missense	probably damaging	1.00
R4828:Or5p1	UTSW	7	107,916,677 (GRCm39)	missense	probably benign	0.00
R6424:Or5p1	UTSW	7	107,916,412 (GRCm39)	missense	probably benign	0.01
R6784:Or5p1	UTSW	7	107,916,989 (GRCm39)	missense	probably damaging	0.98
R7109:Or5p1	UTSW	7	107,916,959 (GRCm39)	missense	probably damaging	1.00
R7348:Or5p1	UTSW	7	107,916,920 (GRCm39)	missense	possibly damaging	0.58
R7590:Or5p1	UTSW	7	107,916,386 (GRCm39)	missense	probably benign	0.00
R8124:Or5p1	UTSW	7	107,916,984 (GRCm39)	missense	possibly damaging	0.48
R8782:Or5p1	UTSW	7	107,916,296 (GRCm39)	missense	probably damaging	0.99
X0060:Or5p1	UTSW	7	107,916,427 (GRCm39)	missense	probably benign	0.06

Posted On

2015-04-16