Incidental Mutation 'IGL02236:Trav14-1'
ID285874
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav14-1
Ensembl Gene ENSMUSG00000076840
Gene NameT cell receptor alpha variable 14-1
SynonymsGm5770
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL02236
Quality Score
Status
Chromosome14
Chromosomal Location53554057-53554554 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 53554306 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 38 (S38T)
Ref Sequence ENSEMBL: ENSMUSP00000143077 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000198297]
Predicted Effect possibly damaging
Transcript: ENSMUST00000198297
AA Change: S38T

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000143077
Gene: ENSMUSG00000076840
AA Change: S38T

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IGv 46 120 2.6e-13 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Baz1b T C 5: 135,217,284 L529P probably damaging Het
Bdp1 A T 13: 100,060,891 D995E probably benign Het
Cd22 T C 7: 30,867,468 N607S possibly damaging Het
Ddx10 T A 9: 53,235,382 D180V probably damaging Het
Dennd4c T C 4: 86,807,435 Y709H possibly damaging Het
Dhrs3 A C 4: 144,893,563 I17L probably benign Het
Dnah8 A T 17: 30,649,773 K394* probably null Het
Flnc T A 6: 29,454,376 I1896N probably damaging Het
Glipr1l2 A G 10: 112,092,629 Y143C probably damaging Het
Lmo7 T C 14: 101,926,088 probably benign Het
Lpp C T 16: 24,762,145 R204W probably damaging Het
Mast3 A G 8: 70,789,244 S98P probably benign Het
Myf5 A G 10: 107,484,190 S200P possibly damaging Het
Olfr582 T G 7: 103,041,721 S76A possibly damaging Het
Pramef8 G A 4: 143,416,942 V93I probably benign Het
Recql5 A C 11: 115,894,030 S824A probably benign Het
Reg2 A G 6: 78,406,205 E45G probably damaging Het
Rergl T C 6: 139,494,920 D77G probably benign Het
Rnf224 T C 2: 25,236,248 D31G probably damaging Het
Sema4c C T 1: 36,553,085 S227N probably damaging Het
Sgsm2 C T 11: 74,859,872 G439D probably damaging Het
Smap2 T A 4: 120,975,390 M185L probably benign Het
Spty2d1 A G 7: 46,997,612 V523A probably benign Het
Stk17b C A 1: 53,764,088 R184L probably damaging Het
Syt13 A G 2: 92,940,865 D99G probably damaging Het
Ttn T C 2: 76,870,468 probably benign Het
Usp17la G A 7: 104,861,146 W319* probably null Het
Vmn2r73 T C 7: 85,872,694 T146A probably benign Het
Vwa3b C T 1: 37,154,051 probably benign Het
Zfp13 A T 17: 23,580,765 probably benign Het
Zscan18 A C 7: 12,769,324 D769E probably benign Het
Other mutations in Trav14-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5258:Trav14-1 UTSW 14 53554273 missense probably benign 0.10
R6340:Trav14-1 UTSW 14 53554498 missense probably damaging 1.00
R6987:Trav14-1 UTSW 14 53554459 nonsense probably null
Posted On2015-04-16