Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02237:Ddx25'

285944

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ddx25

Ensembl Gene

ENSMUSG00000032101

Gene Name

DEAD box helicase 25

Synonyms

DEAD (Asp-Glu-Ala-Asp) box polypeptide 25, GRTH

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.318) question?

Stock #

IGL02237

Quality Score

Status

Chromosome

Chromosomal Location

35453144-35469766 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 35453365 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000034612 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034612]

AlphaFold

Q9QY15

Predicted Effect

probably benign
Transcript: ENSMUST00000034612

SMART Domains

Protein: ENSMUSP00000034612
Gene: ENSMUSG00000032101

Domain	Start	End	E-Value	Type
low complexity region	50	61	N/A	INTRINSIC
low complexity region	101	111	N/A	INTRINSIC
DEXDc	117	316	1.26e-41	SMART
HELICc	353	440	6.18e-27	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd16b	T	A	2: 181,135,350 (GRCm39)	V84E	probably benign	Het
Adam39	A	T	8: 41,278,482 (GRCm39)	E291V	probably benign	Het
Ak5	T	A	3: 152,204,980 (GRCm39)	D372V	probably benign	Het
Brpf1	C	T	6: 113,287,336 (GRCm39)	P188L	probably damaging	Het
Cacna2d3	C	T	14: 29,068,954 (GRCm39)	V258I	probably benign	Het
Cd14	A	G	18: 36,858,912 (GRCm39)	F181S	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cts6	A	T	13: 61,345,313 (GRCm39)	D261E	probably benign	Het
Daam1	A	G	12: 72,029,495 (GRCm39)	T897A	probably benign	Het
Ddx55	A	G	5: 124,705,958 (GRCm39)	E461G	probably damaging	Het
Degs1	T	C	1: 182,107,253 (GRCm39)	K2R	probably damaging	Het
Drc7	C	T	8: 95,799,507 (GRCm39)	L561F	probably damaging	Het
Eif4enif1	A	T	11: 3,177,876 (GRCm39)	K423*	probably null	Het
Epha7	A	G	4: 28,949,325 (GRCm39)		probably null	Het
Erich5	A	C	15: 34,471,482 (GRCm39)	E237A	probably benign	Het
Ficd	A	G	5: 113,876,373 (GRCm39)	T183A	probably damaging	Het
Foxb2	T	C	19: 16,850,908 (GRCm39)	M33V	unknown	Het
Gja8	T	G	3: 96,827,249 (GRCm39)	S138R	probably benign	Het
Gm28042	T	G	2: 119,870,380 (GRCm39)	L743V	possibly damaging	Het
Gtf3c2	A	T	5: 31,316,397 (GRCm39)		probably benign	Het
Itga11	T	C	9: 62,663,057 (GRCm39)		probably null	Het
Kazn	A	T	4: 141,874,410 (GRCm39)	D315E	probably benign	Het
Kbtbd2	A	T	6: 56,756,033 (GRCm39)	S568T	possibly damaging	Het
Man1c1	A	C	4: 134,311,609 (GRCm39)		probably null	Het
Myh9	A	G	15: 77,670,854 (GRCm39)	S463P	probably benign	Het
Nlrp4a	G	T	7: 26,148,703 (GRCm39)	K103N	possibly damaging	Het
Oog2	T	A	4: 143,923,016 (GRCm39)	F427Y	possibly damaging	Het
Pcmtd1	T	C	1: 7,233,601 (GRCm39)		probably null	Het
Pcnt	C	A	10: 76,188,818 (GRCm39)	D2861Y	probably damaging	Het
Pdzd7	C	T	19: 45,028,697 (GRCm39)	A149T	probably damaging	Het
Pebp4	A	T	14: 70,297,105 (GRCm39)	T215S	possibly damaging	Het
Pgm1	T	C	4: 99,820,707 (GRCm39)		probably benign	Het
Plekhh2	T	A	17: 84,883,213 (GRCm39)	D760E	probably benign	Het
Pomt1	T	C	2: 32,135,689 (GRCm39)	I351T	probably benign	Het
Ptpn21	C	T	12: 98,671,351 (GRCm39)		probably null	Het
Rsad2	T	G	12: 26,506,186 (GRCm39)	Y78S	probably damaging	Het
Rsbn1l	A	T	5: 21,124,604 (GRCm39)	N399K	probably benign	Het
Sec31a	A	G	5: 100,509,914 (GRCm39)	V1191A	probably damaging	Het
Sema6c	C	T	3: 95,077,430 (GRCm39)	P414L	probably damaging	Het
Serpinb5	T	C	1: 106,808,056 (GRCm39)	S69P	probably benign	Het
Slc25a13	C	T	6: 6,042,646 (GRCm39)	R586H	probably damaging	Het
Spink5	T	A	18: 44,145,934 (GRCm39)	M776K	probably benign	Het
Srcap	A	G	7: 127,133,864 (GRCm39)		probably benign	Het
Stt3a	G	A	9: 36,660,933 (GRCm39)	Q293*	probably null	Het
Syne4	T	A	7: 30,015,988 (GRCm39)		probably null	Het
Tomm40l	C	T	1: 171,048,463 (GRCm39)	V97M	possibly damaging	Het
Trpc4	C	T	3: 54,129,783 (GRCm39)	S183F	probably damaging	Het
Ttn	C	T	2: 76,716,478 (GRCm39)		probably benign	Het
Ufl1	A	C	4: 25,269,082 (GRCm39)	S170A	probably benign	Het
Vmn2r66	G	A	7: 84,643,908 (GRCm39)	T834I	probably benign	Het
Vmn2r75	A	G	7: 85,814,786 (GRCm39)	S236P	possibly damaging	Het
Zfp345	A	T	2: 150,316,805 (GRCm39)		probably benign	Het
Zfp955b	T	C	17: 33,520,893 (GRCm39)	S121P	probably damaging	Het

Other mutations in Ddx25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Ddx25	APN	9	35,454,891 (GRCm39)	splice site	probably benign
IGL00951:Ddx25	APN	9	35,464,131 (GRCm39)	critical splice donor site	probably null
IGL02270:Ddx25	APN	9	35,465,708 (GRCm39)	splice site	probably benign
IGL02273:Ddx25	APN	9	35,458,122 (GRCm39)	missense	possibly damaging	0.95
IGL02325:Ddx25	APN	9	35,465,804 (GRCm39)	unclassified	probably benign
IGL02422:Ddx25	APN	9	35,462,660 (GRCm39)	missense	probably null	1.00
IGL02440:Ddx25	APN	9	35,468,974 (GRCm39)	unclassified	probably benign
IGL02798:Ddx25	APN	9	35,462,693 (GRCm39)	missense	probably damaging	1.00
IGL03339:Ddx25	APN	9	35,453,299 (GRCm39)	missense	probably damaging	1.00
R0633:Ddx25	UTSW	9	35,457,268 (GRCm39)	missense	probably damaging	0.99
R0893:Ddx25	UTSW	9	35,465,686 (GRCm39)	nonsense	probably null
R1171:Ddx25	UTSW	9	35,458,142 (GRCm39)	nonsense	probably null
R1448:Ddx25	UTSW	9	35,469,034 (GRCm39)	missense	probably benign
R1453:Ddx25	UTSW	9	35,453,298 (GRCm39)	missense	probably damaging	1.00
R1582:Ddx25	UTSW	9	35,457,272 (GRCm39)	missense	probably damaging	0.97
R3055:Ddx25	UTSW	9	35,462,647 (GRCm39)	missense	probably damaging	1.00
R5960:Ddx25	UTSW	9	35,465,807 (GRCm39)	splice site	probably null
R7425:Ddx25	UTSW	9	35,465,882 (GRCm39)	missense	probably benign	0.08
R7535:Ddx25	UTSW	9	35,454,951 (GRCm39)	missense	possibly damaging	0.89
R7610:Ddx25	UTSW	9	35,465,893 (GRCm39)	missense	possibly damaging	0.90
R8758:Ddx25	UTSW	9	35,453,300 (GRCm39)	missense	probably benign
R8931:Ddx25	UTSW	9	35,465,864 (GRCm39)	missense	possibly damaging	0.85
R8984:Ddx25	UTSW	9	35,468,685 (GRCm39)	missense	probably benign
R9103:Ddx25	UTSW	9	35,458,085 (GRCm39)	missense	probably benign	0.24
R9585:Ddx25	UTSW	9	35,455,009 (GRCm39)	nonsense	probably null
R9759:Ddx25	UTSW	9	35,457,265 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16