Incidental Mutation 'IGL02240:Gsta2'
ID 286035
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gsta2
Ensembl Gene ENSMUSG00000057933
Gene Name glutathione S-transferase, alpha 2 (Yc2)
Synonyms Gstc2, Gstc-2, Gst2-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # IGL02240
Quality Score
Status
Chromosome 9
Chromosomal Location 78238300-78254474 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78238441 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 213 (I213F)
Ref Sequence ENSEMBL: ENSMUSP00000034902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034902] [ENSMUST00000043734] [ENSMUST00000125479] [ENSMUST00000129247] [ENSMUST00000186336] [ENSMUST00000187667]
AlphaFold P10648
PDB Structure Crystal Structure of mGSTA2-2 in Complex with the Glutathione Conjugate of Benzo[a]pyrene-7(R),8(S)-Diol-9(S),10(R)-Epoxide [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000034902
AA Change: I213F

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000034902
Gene: ENSMUSG00000057933
AA Change: I213F

DomainStartEndE-ValueType
Pfam:GST_N 5 77 5.1e-23 PFAM
Pfam:GST_C 99 192 8.9e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000043734
SMART Domains Protein: ENSMUSP00000036132
Gene: ENSMUSG00000038750

DomainStartEndE-ValueType
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125479
SMART Domains Protein: ENSMUSP00000115517
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.1e-21 PFAM
Pfam:GST_C 78 182 1.1e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129247
SMART Domains Protein: ENSMUSP00000117101
Gene: ENSMUSG00000057933

DomainStartEndE-ValueType
Pfam:GST_N 5 77 1.1e-21 PFAM
Pfam:GST_C 78 179 1.2e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140498
Predicted Effect probably benign
Transcript: ENSMUST00000186336
Predicted Effect probably benign
Transcript: ENSMUST00000187667
SMART Domains Protein: ENSMUSP00000139767
Gene: ENSMUSG00000038750

DomainStartEndE-ValueType
transmembrane domain 69 91 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187890
Predicted Effect probably benign
Transcript: ENSMUST00000189243
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cand2 A G 6: 115,780,623 (GRCm39) E1169G probably damaging Het
Cdc34 A G 10: 79,523,823 (GRCm39) D168G possibly damaging Het
Cwc27 A T 13: 104,943,151 (GRCm39) F130L probably damaging Het
Dglucy T A 12: 100,837,672 (GRCm39) M635K possibly damaging Het
Eral1 G A 11: 77,968,687 (GRCm39) R149* probably null Het
Gad1-ps A G 10: 99,280,820 (GRCm39) noncoding transcript Het
Glis3 A T 19: 28,508,925 (GRCm39) L353Q probably damaging Het
Ist1 A T 8: 110,408,836 (GRCm39) probably benign Het
Kif1b A G 4: 149,330,871 (GRCm39) V549A probably damaging Het
Lrp2 C T 2: 69,365,390 (GRCm39) R261H probably benign Het
Msh4 T C 3: 153,579,311 (GRCm39) N512S probably damaging Het
Nlrp2 A T 7: 5,330,822 (GRCm39) S525T probably damaging Het
Nlrp4a G T 7: 26,148,703 (GRCm39) K103N possibly damaging Het
Or8b56 T A 9: 38,739,602 (GRCm39) V205D probably benign Het
Pcdhb10 A T 18: 37,545,455 (GRCm39) H177L possibly damaging Het
Plcb3 A T 19: 6,935,448 (GRCm39) probably benign Het
Podxl A G 6: 31,501,933 (GRCm39) L342P probably damaging Het
Psd4 T G 2: 24,286,389 (GRCm39) S330A probably benign Het
Sucla2 A G 14: 73,828,287 (GRCm39) D298G probably damaging Het
Tecr T C 8: 84,300,045 (GRCm39) D107G probably damaging Het
Vamp4 T A 1: 162,405,446 (GRCm39) N24K possibly damaging Het
Zfp91 A G 19: 12,753,770 (GRCm39) probably benign Het
Other mutations in Gsta2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Gsta2 APN 9 78,238,525 (GRCm39) nonsense probably null
IGL03057:Gsta2 APN 9 78,241,192 (GRCm39) unclassified probably benign
R1476:Gsta2 UTSW 9 78,249,147 (GRCm39) missense probably benign 0.02
R4972:Gsta2 UTSW 9 78,244,961 (GRCm39) missense probably damaging 0.98
R7269:Gsta2 UTSW 9 78,239,419 (GRCm39) missense probably benign 0.07
R8855:Gsta2 UTSW 9 78,244,880 (GRCm39) missense probably damaging 0.98
R9766:Gsta2 UTSW 9 78,244,876 (GRCm39) nonsense probably null
Posted On 2015-04-16