Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02240:Zfp91'

286044

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp91

Ensembl Gene

ENSMUSG00000024695

Gene Name

zinc finger protein 91

Synonyms

Pzf, 9130014I08Rik, A530054C17Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.488) question?

Stock #

IGL02240

Quality Score

Status

Chromosome

Chromosomal Location

12744384-12773490 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 12753770 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124424 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038627] [ENSMUST00000142247]

AlphaFold

Q62511

Predicted Effect

probably benign
Transcript: ENSMUST00000038627

SMART Domains

Protein: ENSMUSP00000037971
Gene: ENSMUSG00000024695

Domain	Start	End	E-Value	Type
low complexity region	21	27	N/A	INTRINSIC
low complexity region	35	43	N/A	INTRINSIC
low complexity region	72	92	N/A	INTRINSIC
low complexity region	98	114	N/A	INTRINSIC
low complexity region	120	135	N/A	INTRINSIC
low complexity region	143	167	N/A	INTRINSIC
low complexity region	207	226	N/A	INTRINSIC
coiled coil region	256	284	N/A	INTRINSIC
ZnF_C2H2	313	338	1.08e-1	SMART
ZnF_C2H2	344	368	7.15e-2	SMART
ZnF_C2H2	374	396	1.56e-2	SMART
ZnF_C2H2	402	424	2.61e-4	SMART
ZnF_C2H2	432	455	1.92e-2	SMART
low complexity region	459	471	N/A	INTRINSIC
low complexity region	491	502	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137256

Predicted Effect

probably benign
Transcript: ENSMUST00000142247

SMART Domains

Protein: ENSMUSP00000124424
Gene: ENSMUSG00000024695

Domain	Start	End	E-Value	Type
low complexity region	21	27	N/A	INTRINSIC
low complexity region	35	43	N/A	INTRINSIC
low complexity region	72	92	N/A	INTRINSIC
low complexity region	98	114	N/A	INTRINSIC
low complexity region	120	135	N/A	INTRINSIC
low complexity region	143	167	N/A	INTRINSIC
low complexity region	207	226	N/A	INTRINSIC
coiled coil region	256	284	N/A	INTRINSIC
ZnF_C2H2	313	338	1.08e-1	SMART
ZnF_C2H2	344	368	7.15e-2	SMART
ZnF_C2H2	374	396	1.56e-2	SMART
ZnF_C2H2	402	424	2.61e-4	SMART
ZnF_C2H2	432	455	1.92e-2	SMART
low complexity region	459	471	N/A	INTRINSIC
low complexity region	491	502	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. The homologous human protein has been shown to function as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. A read-through transcript variant composed of Zfp91 and the downstream Cntf gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. A Zfp91-related pseudogene has also been identified on chromosome 17. [provided by RefSeq, Oct 2010]

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cand2	A	G	6: 115,780,623 (GRCm39)	E1169G	probably damaging	Het
Cdc34	A	G	10: 79,523,823 (GRCm39)	D168G	possibly damaging	Het
Cwc27	A	T	13: 104,943,151 (GRCm39)	F130L	probably damaging	Het
Dglucy	T	A	12: 100,837,672 (GRCm39)	M635K	possibly damaging	Het
Eral1	G	A	11: 77,968,687 (GRCm39)	R149*	probably null	Het
Gad1-ps	A	G	10: 99,280,820 (GRCm39)		noncoding transcript	Het
Glis3	A	T	19: 28,508,925 (GRCm39)	L353Q	probably damaging	Het
Gsta2	T	A	9: 78,238,441 (GRCm39)	I213F	probably benign	Het
Ist1	A	T	8: 110,408,836 (GRCm39)		probably benign	Het
Kif1b	A	G	4: 149,330,871 (GRCm39)	V549A	probably damaging	Het
Lrp2	C	T	2: 69,365,390 (GRCm39)	R261H	probably benign	Het
Msh4	T	C	3: 153,579,311 (GRCm39)	N512S	probably damaging	Het
Nlrp2	A	T	7: 5,330,822 (GRCm39)	S525T	probably damaging	Het
Nlrp4a	G	T	7: 26,148,703 (GRCm39)	K103N	possibly damaging	Het
Or8b56	T	A	9: 38,739,602 (GRCm39)	V205D	probably benign	Het
Pcdhb10	A	T	18: 37,545,455 (GRCm39)	H177L	possibly damaging	Het
Plcb3	A	T	19: 6,935,448 (GRCm39)		probably benign	Het
Podxl	A	G	6: 31,501,933 (GRCm39)	L342P	probably damaging	Het
Psd4	T	G	2: 24,286,389 (GRCm39)	S330A	probably benign	Het
Sucla2	A	G	14: 73,828,287 (GRCm39)	D298G	probably damaging	Het
Tecr	T	C	8: 84,300,045 (GRCm39)	D107G	probably damaging	Het
Vamp4	T	A	1: 162,405,446 (GRCm39)	N24K	possibly damaging	Het

Other mutations in Zfp91

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0139:Zfp91	UTSW	19	12,747,834 (GRCm39)	missense	probably damaging	1.00
R0369:Zfp91	UTSW	19	12,747,438 (GRCm39)	missense	possibly damaging	0.95
R0485:Zfp91	UTSW	19	12,753,353 (GRCm39)	splice site	probably benign
R0559:Zfp91	UTSW	19	12,747,419 (GRCm39)	missense	probably damaging	1.00
R0597:Zfp91	UTSW	19	12,747,459 (GRCm39)	missense	possibly damaging	0.53
R1565:Zfp91	UTSW	19	12,756,439 (GRCm39)	missense	probably benign	0.02
R3422:Zfp91	UTSW	19	12,747,656 (GRCm39)	missense	probably benign	0.24
R4438:Zfp91	UTSW	19	12,755,385 (GRCm39)	nonsense	probably null
R4898:Zfp91	UTSW	19	12,747,424 (GRCm39)	missense	probably damaging	1.00
R4927:Zfp91	UTSW	19	12,753,774 (GRCm39)	critical splice donor site	probably null
R5509:Zfp91	UTSW	19	12,756,451 (GRCm39)	missense	probably damaging	0.99
R5878:Zfp91	UTSW	19	12,747,684 (GRCm39)	missense	possibly damaging	0.80
R5978:Zfp91	UTSW	19	12,747,515 (GRCm39)	missense	probably benign	0.43
R7703:Zfp91	UTSW	19	12,754,241 (GRCm39)	missense	probably benign	0.24
R7864:Zfp91	UTSW	19	12,748,403 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16