Incidental Mutation 'IGL02246:Vmn1r169'
ID286182
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r169
Ensembl Gene ENSMUSG00000094602
Gene Namevomeronasal 1 receptor 169
SynonymsGm4232
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL02246
Quality Score
Status
Chromosome7
Chromosomal Location23575526-23578849 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 23577236 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 18 (I18L)
Ref Sequence ENSEMBL: ENSMUSP00000154343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170290] [ENSMUST00000226669] [ENSMUST00000227547] [ENSMUST00000227932] [ENSMUST00000228832]
Predicted Effect probably benign
Transcript: ENSMUST00000170290
AA Change: I18L

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000126133
Gene: ENSMUSG00000094602
AA Change: I18L

DomainStartEndE-ValueType
Pfam:TAS2R 8 295 4e-14 PFAM
Pfam:V1R 41 295 2.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226669
AA Change: I18L

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000227547
AA Change: I18L

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000227932
AA Change: I18L

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000228832
AA Change: I18L

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik G T 4: 123,860,862 D190Y probably damaging Het
Acat1 G A 9: 53,584,866 L324F probably benign Het
Ago2 T C 15: 73,108,418 H743R probably damaging Het
Ahnak A T 19: 9,008,268 L2305F probably damaging Het
Ankhd1 T A 18: 36,656,726 H2438Q probably damaging Het
Atm G T 9: 53,527,185 Q162K probably benign Het
Bpifa6 A T 2: 153,989,276 E254V probably damaging Het
Carns1 T A 19: 4,166,432 N584Y possibly damaging Het
Cmklr1 T C 5: 113,614,400 N180S probably benign Het
Col6a5 G A 9: 105,911,107 R1565* probably null Het
Fbxo43 T A 15: 36,162,696 I122L probably benign Het
Fibp A G 19: 5,463,236 Y193C probably damaging Het
Gm10923 A G 15: 85,116,931 probably benign Het
Il12rb2 A G 6: 67,308,956 probably null Het
Jakmip2 T C 18: 43,567,158 E445G possibly damaging Het
Krcc1 G A 6: 71,284,421 D146N probably benign Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Map2k5 A T 9: 63,377,129 D43E probably benign Het
Nup155 A G 15: 8,143,002 K824R probably benign Het
Olfr1394 T C 11: 49,160,094 S27P probably benign Het
Olfr577 T C 7: 102,973,744 T83A possibly damaging Het
Phkg1 G A 5: 129,864,638 R324W probably damaging Het
Plcd1 G A 9: 119,072,609 L616F probably benign Het
Rnf141 A T 7: 110,825,287 S122T probably benign Het
Tap1 G A 17: 34,193,989 V593M probably benign Het
Ticrr T C 7: 79,675,328 L534P probably damaging Het
Ubr4 G T 4: 139,459,103 E640D possibly damaging Het
Other mutations in Vmn1r169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00897:Vmn1r169 APN 7 23577594 missense probably damaging 1.00
IGL01019:Vmn1r169 APN 7 23577186 start codon destroyed probably null 0.99
IGL01667:Vmn1r169 APN 7 23577800 missense probably benign 0.17
IGL03303:Vmn1r169 APN 7 23578009 missense probably benign 0.40
R1345:Vmn1r169 UTSW 7 23577822 missense probably damaging 1.00
R6471:Vmn1r169 UTSW 7 23577545 missense probably benign 0.25
R7120:Vmn1r169 UTSW 7 23578019 missense probably benign 0.00
Posted On2015-04-16