Incidental Mutation 'IGL02247:Or4n4b'
ID 286225
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4n4b
Ensembl Gene ENSMUSG00000090874
Gene Name olfactory receptor family 4 subfamily N member 4B
Synonyms Olfr733, GA_x6K02T2PMLR-5992342-5991416, MOR241-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL02247
Quality Score
Status
Chromosome 14
Chromosomal Location 50535794-50536787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50536571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 65 (N65I)
Ref Sequence ENSEMBL: ENSMUSP00000149807 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163469] [ENSMUST00000214372] [ENSMUST00000214756] [ENSMUST00000216195]
AlphaFold Q14AK5
Predicted Effect probably damaging
Transcript: ENSMUST00000163469
AA Change: N65I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000128332
Gene: ENSMUSG00000090874
AA Change: N65I

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 6.4e-41 PFAM
Pfam:7tm_1 41 288 1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214372
AA Change: N65I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000214756
AA Change: N65I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000216195
AA Change: N65I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl2 A G 2: 26,974,905 (GRCm39) R177G probably damaging Het
Ap3b1 T C 13: 94,531,303 (GRCm39) probably null Het
Ascc3 A C 10: 50,526,686 (GRCm39) K595T probably damaging Het
Cnpy4 A G 5: 138,191,125 (GRCm39) T234A probably benign Het
Col13a1 T C 10: 61,797,124 (GRCm39) Y101C probably damaging Het
Crybg3 A G 16: 59,323,513 (GRCm39) I2809T probably damaging Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dgkz T C 2: 91,767,805 (GRCm39) S824G probably benign Het
Dsg1c T A 18: 20,397,373 (GRCm39) I27N probably damaging Het
Efhb C T 17: 53,708,652 (GRCm39) V673I probably benign Het
Egr1 T C 18: 34,995,916 (GRCm39) Y233H possibly damaging Het
Fam184a T C 10: 53,551,256 (GRCm39) E237G probably damaging Het
Galt A G 4: 41,755,623 (GRCm39) probably benign Het
Gm4795 T C 10: 44,883,211 (GRCm39) noncoding transcript Het
Gm6563 G A 19: 23,653,392 (GRCm39) E61K possibly damaging Het
Igkv1-133 G A 6: 67,702,590 (GRCm39) V103M probably damaging Het
Iqcb1 T A 16: 36,660,258 (GRCm39) H140Q probably benign Het
Itpk1 G T 12: 102,589,668 (GRCm39) P74Q probably damaging Het
Itpr3 T A 17: 27,317,153 (GRCm39) W803R probably damaging Het
Lgr4 A T 2: 109,832,846 (GRCm39) D312V probably benign Het
Lgr4 C T 2: 109,838,420 (GRCm39) probably benign Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Mllt6 C A 11: 97,561,158 (GRCm39) A282E probably benign Het
Mtif2 T C 11: 29,490,642 (GRCm39) S449P possibly damaging Het
Nrg3 T C 14: 38,093,269 (GRCm39) I533M probably damaging Het
Nynrin C T 14: 56,109,167 (GRCm39) Q1425* probably null Het
Or12e13 A G 2: 87,663,873 (GRCm39) I163M probably damaging Het
Or1e1f A T 11: 73,855,688 (GRCm39) M85L probably benign Het
Or4p22 C T 2: 88,317,771 (GRCm39) H232Y probably benign Het
Or56a3 T A 7: 104,735,530 (GRCm39) Y202* probably null Het
Or5b3 T A 19: 13,388,831 (GRCm39) S299R probably benign Het
Or7e175 G A 9: 20,048,516 (GRCm39) V35I probably benign Het
Plcb4 C T 2: 135,836,245 (GRCm39) T20I possibly damaging Het
Ppp1r12b G T 1: 134,763,721 (GRCm39) T771K probably benign Het
Prss22 T C 17: 24,215,363 (GRCm39) T138A probably benign Het
Ros1 A T 10: 52,005,677 (GRCm39) S907T probably damaging Het
Rtel1 T A 2: 180,993,134 (GRCm39) Y521* probably null Het
Sacs T C 14: 61,429,984 (GRCm39) F678S probably damaging Het
Smtnl1 A T 2: 84,647,372 (GRCm39) probably benign Het
Sumf2 T C 5: 129,888,986 (GRCm39) V258A probably damaging Het
Tas1r2 A T 4: 139,396,827 (GRCm39) Y722F probably damaging Het
Tecpr1 A G 5: 144,143,372 (GRCm39) F668L possibly damaging Het
Timd4 T C 11: 46,706,558 (GRCm39) F120S probably damaging Het
Tnnt3 T C 7: 142,062,062 (GRCm39) probably benign Het
Trp53bp1 G A 2: 121,067,070 (GRCm39) S552F probably damaging Het
Txlnb G A 10: 17,706,090 (GRCm39) R333Q possibly damaging Het
Txlnb A G 10: 17,717,276 (GRCm39) probably benign Het
Uroc1 A G 6: 90,324,910 (GRCm39) E461G probably benign Het
Vps45 G A 3: 95,950,236 (GRCm39) T231I probably damaging Het
Zfp648 T A 1: 154,079,923 (GRCm39) S27R probably benign Het
Other mutations in Or4n4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01879:Or4n4b APN 14 50,535,969 (GRCm39) missense probably benign 0.00
IGL02307:Or4n4b APN 14 50,536,295 (GRCm39) missense probably damaging 1.00
IGL02492:Or4n4b APN 14 50,536,060 (GRCm39) missense probably damaging 1.00
PIT4378001:Or4n4b UTSW 14 50,536,355 (GRCm39) missense probably benign
R0544:Or4n4b UTSW 14 50,536,139 (GRCm39) missense probably benign 0.20
R1603:Or4n4b UTSW 14 50,536,491 (GRCm39) missense possibly damaging 0.95
R1881:Or4n4b UTSW 14 50,536,472 (GRCm39) missense probably damaging 1.00
R3731:Or4n4b UTSW 14 50,535,962 (GRCm39) missense probably damaging 1.00
R4271:Or4n4b UTSW 14 50,535,908 (GRCm39) missense probably damaging 1.00
R4512:Or4n4b UTSW 14 50,536,453 (GRCm39) missense probably damaging 1.00
R5601:Or4n4b UTSW 14 50,536,318 (GRCm39) missense probably damaging 1.00
R6468:Or4n4b UTSW 14 50,535,924 (GRCm39) missense probably benign 0.02
R6614:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign 0.00
R7013:Or4n4b UTSW 14 50,536,656 (GRCm39) missense probably damaging 0.99
R7083:Or4n4b UTSW 14 50,536,736 (GRCm39) missense possibly damaging 0.81
R7274:Or4n4b UTSW 14 50,535,879 (GRCm39) missense probably benign 0.01
R7493:Or4n4b UTSW 14 50,536,281 (GRCm39) missense probably benign 0.02
R7653:Or4n4b UTSW 14 50,536,604 (GRCm39) missense possibly damaging 0.82
R7659:Or4n4b UTSW 14 50,536,698 (GRCm39) missense probably benign 0.00
R7885:Or4n4b UTSW 14 50,536,041 (GRCm39) missense probably damaging 1.00
R9138:Or4n4b UTSW 14 50,536,494 (GRCm39) missense probably benign
R9497:Or4n4b UTSW 14 50,536,362 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16