Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02249:Tmem207'

286313

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem207

Ensembl Gene

ENSMUSG00000091972

Gene Name

transmembrane protein 207

Synonyms

100043057, LOC224058

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL02249

Quality Score

Status

Chromosome

Chromosomal Location

26322543-26345521 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 26336617 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 46 (Y46N)

Ref Sequence

ENSEMBL: ENSMUSP00000127563 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165687]

AlphaFold

P86045

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165687
AA Change: Y46N

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000127563
Gene: ENSMUSG00000091972
AA Change: Y46N

Domain	Start	End	E-Value	Type
Pfam:TMEM52	31	92	4.2e-10	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231658

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019A02Rik	T	A	1: 53,224,431 (GRCm39)	K23*	probably null	Het
Abca1	A	T	4: 53,068,739 (GRCm39)	L1333*	probably null	Het
Adcy6	C	A	15: 98,497,795 (GRCm39)	M452I	probably damaging	Het
Adsl	G	A	15: 80,844,676 (GRCm39)	R173H	probably benign	Het
Ank3	A	G	10: 69,718,200 (GRCm39)	T484A	probably damaging	Het
Apol10a	A	G	15: 77,372,709 (GRCm39)	D115G	probably damaging	Het
Bard1	A	G	1: 71,092,828 (GRCm39)	S529P	probably damaging	Het
C2	A	G	17: 35,083,484 (GRCm39)		probably benign	Het
Cftr	T	A	6: 18,277,870 (GRCm39)	I956N	possibly damaging	Het
Cwc15	A	G	9: 14,414,977 (GRCm39)	T110A	probably benign	Het
Dsg4	A	T	18: 20,594,361 (GRCm39)	I497F	possibly damaging	Het
Gadd45b	A	G	10: 80,766,967 (GRCm39)	D69G	possibly damaging	Het
Glb1l3	A	T	9: 26,742,564 (GRCm39)	S307R	possibly damaging	Het
Greb1l	G	A	18: 10,532,961 (GRCm39)	G843R	probably damaging	Het
H2-M11	A	T	17: 36,858,829 (GRCm39)	Y123F	probably benign	Het
Hal	G	A	10: 93,333,400 (GRCm39)	A323T	probably damaging	Het
Il4ra	T	C	7: 125,166,396 (GRCm39)	F47L	probably benign	Het
Klra10	T	A	6: 130,256,367 (GRCm39)	N96Y	probably benign	Het
Maco1	T	C	4: 134,555,623 (GRCm39)	I283M	possibly damaging	Het
Mki67	T	A	7: 135,302,251 (GRCm39)	M928L	possibly damaging	Het
Myh15	T	A	16: 48,930,847 (GRCm39)	V607D	probably damaging	Het
Ndufaf2	A	G	13: 108,217,925 (GRCm39)	W74R	probably damaging	Het
Noc4l	C	A	5: 110,801,081 (GRCm39)		probably benign	Het
Or51b6b	T	A	7: 103,309,573 (GRCm39)	I295F	probably damaging	Het
Papss1	T	A	3: 131,307,772 (GRCm39)	W274R	probably damaging	Het
Pax3	C	T	1: 78,171,962 (GRCm39)	V83I	probably damaging	Het
Prmt5	C	T	14: 54,747,322 (GRCm39)	R485H	probably damaging	Het
Ptprq	A	G	10: 107,418,220 (GRCm39)	Y1719H	probably damaging	Het
Ranbp2	A	T	10: 58,315,900 (GRCm39)	I2207F	possibly damaging	Het
Rock2	T	A	12: 17,021,042 (GRCm39)		probably benign	Het
Sema3c	G	A	5: 17,867,961 (GRCm39)	R124H	probably damaging	Het
Serpina1e	G	A	12: 103,917,393 (GRCm39)	T92M	probably benign	Het
Sgip1	T	C	4: 102,768,667 (GRCm39)	L83P	probably benign	Het
Tm9sf2	C	T	14: 122,361,162 (GRCm39)	S68L	probably damaging	Het
Tmem178	A	G	17: 81,297,235 (GRCm39)	T206A	probably damaging	Het
Tyk2	A	G	9: 21,031,703 (GRCm39)	L429P	probably damaging	Het

Other mutations in Tmem207

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01101:Tmem207	APN	16	26,336,627 (GRCm39)	nonsense	probably null
IGL02140:Tmem207	APN	16	26,335,490 (GRCm39)	missense	probably benign	0.01
IGL02394:Tmem207	APN	16	26,335,586 (GRCm39)	splice site	probably benign
IGL03380:Tmem207	APN	16	26,345,407 (GRCm39)	missense	probably damaging	1.00
R0058:Tmem207	UTSW	16	26,343,579 (GRCm39)	splice site	probably benign
R0058:Tmem207	UTSW	16	26,343,579 (GRCm39)	splice site	probably benign
R1839:Tmem207	UTSW	16	26,343,571 (GRCm39)	missense	possibly damaging	0.80
R4943:Tmem207	UTSW	16	26,336,603 (GRCm39)	nonsense	probably null
R7348:Tmem207	UTSW	16	26,335,577 (GRCm39)	missense	possibly damaging	0.68
R7947:Tmem207	UTSW	16	26,335,495 (GRCm39)	missense	possibly damaging	0.82
R9358:Tmem207	UTSW	16	26,345,434 (GRCm39)	missense	probably benign	0.07
R9464:Tmem207	UTSW	16	26,345,413 (GRCm39)	missense
R9564:Tmem207	UTSW	16	26,335,499 (GRCm39)	nonsense	probably null

Posted On

2015-04-16