Incidental Mutation 'IGL02250:Zfp873'
| ID |
286344 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp873
|
| Ensembl Gene |
ENSMUSG00000061371 |
| Gene Name |
zinc finger protein 873 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.083)
|
| Stock # |
IGL02250
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
81883957-81900579 bp(+) (GRCm39) |
| Type of Mutation |
start codon destroyed |
| DNA Base Change (assembly) |
T to A
at 81894252 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 1
(M1K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000100950
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000105313]
[ENSMUST00000209622]
[ENSMUST00000210325]
|
| AlphaFold |
A0A1B0GT64 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000105313
AA Change: M1K
PolyPhen 2
Score 0.447 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000100950
Gene: ENSMUSG00000061371
AA Change: M1K
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
68 |
90 |
1.12e2 |
SMART |
|
ZnF_C2H2
|
96 |
117 |
4.69e0 |
SMART |
|
ZnF_C2H2
|
123 |
145 |
2.06e1 |
SMART |
|
ZnF_C2H2
|
151 |
173 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
179 |
201 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
207 |
229 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
235 |
257 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
263 |
285 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
291 |
313 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
319 |
341 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
347 |
369 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
375 |
397 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
403 |
425 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
431 |
453 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
459 |
481 |
5.99e-4 |
SMART |
|
ZnF_C2H2
|
487 |
509 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
515 |
537 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
543 |
565 |
2.53e-2 |
SMART |
|
ZnF_C2H2
|
571 |
593 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
599 |
619 |
3.13e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209614
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000209622
AA Change: W18R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000210325
AA Change: W18R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211338
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219748
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp7 |
T |
A |
7: 28,329,135 (GRCm39) |
|
probably benign |
Het |
| Antxr2 |
A |
C |
5: 98,125,454 (GRCm39) |
|
probably null |
Het |
| Areg |
T |
A |
5: 91,288,967 (GRCm39) |
I91K |
possibly damaging |
Het |
| Arf1 |
G |
A |
11: 59,103,993 (GRCm39) |
R79C |
probably benign |
Het |
| Bbs2 |
A |
T |
8: 94,819,054 (GRCm39) |
I105N |
probably benign |
Het |
| Ccdc158 |
A |
T |
5: 92,756,337 (GRCm39) |
I1090N |
probably damaging |
Het |
| Ccdc90b |
T |
A |
7: 92,223,823 (GRCm39) |
|
probably benign |
Het |
| Cep57 |
A |
T |
9: 13,721,939 (GRCm39) |
F221I |
probably damaging |
Het |
| Ckap5 |
C |
T |
2: 91,379,246 (GRCm39) |
A62V |
probably damaging |
Het |
| Cntn5 |
G |
A |
9: 10,145,336 (GRCm39) |
R125C |
probably damaging |
Het |
| Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
| Cxxc1 |
T |
A |
18: 74,352,240 (GRCm39) |
D321E |
probably benign |
Het |
| Ddr1 |
G |
A |
17: 35,994,372 (GRCm39) |
A801V |
probably damaging |
Het |
| Dnm1l |
A |
G |
16: 16,139,550 (GRCm39) |
|
probably benign |
Het |
| Eif2d |
T |
A |
1: 131,088,166 (GRCm39) |
S184T |
probably benign |
Het |
| Emcn |
T |
A |
3: 137,124,747 (GRCm39) |
|
probably benign |
Het |
| Fry |
A |
T |
5: 150,326,899 (GRCm39) |
|
probably benign |
Het |
| Gas2 |
T |
A |
7: 51,537,786 (GRCm39) |
M37K |
probably damaging |
Het |
| Habp2 |
A |
G |
19: 56,297,361 (GRCm39) |
S100G |
probably benign |
Het |
| Kcnj5 |
A |
G |
9: 32,229,052 (GRCm39) |
C49R |
probably damaging |
Het |
| Lhx2 |
T |
A |
2: 38,244,845 (GRCm39) |
D236E |
probably benign |
Het |
| Megf8 |
T |
A |
7: 25,042,000 (GRCm39) |
S1273T |
probably benign |
Het |
| Mrps2 |
T |
C |
2: 28,359,557 (GRCm39) |
I138T |
possibly damaging |
Het |
| Mta1 |
T |
C |
12: 113,090,418 (GRCm39) |
S175P |
possibly damaging |
Het |
| Npat |
T |
A |
9: 53,460,251 (GRCm39) |
Y66* |
probably null |
Het |
| Nup160 |
A |
G |
2: 90,539,214 (GRCm39) |
R798G |
probably damaging |
Het |
| Or52n2c |
T |
C |
7: 104,574,222 (GRCm39) |
I250V |
probably damaging |
Het |
| Or8b54 |
C |
A |
9: 38,686,850 (GRCm39) |
Q100K |
probably damaging |
Het |
| Plxnc1 |
C |
T |
10: 94,706,893 (GRCm39) |
G548E |
probably benign |
Het |
| Radil |
A |
G |
5: 142,529,529 (GRCm39) |
S56P |
probably damaging |
Het |
| Rpgrip1l |
A |
T |
8: 91,959,489 (GRCm39) |
M1137K |
probably benign |
Het |
| Serpina1c |
T |
G |
12: 103,863,487 (GRCm39) |
M238L |
probably benign |
Het |
| Tbc1d14 |
A |
G |
5: 36,728,863 (GRCm39) |
S168P |
probably damaging |
Het |
| Tmem209 |
A |
G |
6: 30,487,387 (GRCm39) |
S498P |
probably damaging |
Het |
| Utrn |
A |
G |
10: 12,312,135 (GRCm39) |
Y607H |
probably damaging |
Het |
| Vipr1 |
A |
G |
9: 121,494,255 (GRCm39) |
I279V |
probably benign |
Het |
| Vmn2r67 |
T |
G |
7: 84,805,008 (GRCm39) |
N35H |
probably benign |
Het |
| Xirp2 |
C |
T |
2: 67,344,356 (GRCm39) |
T2199I |
probably benign |
Het |
| Zfp423 |
A |
G |
8: 88,509,883 (GRCm39) |
S86P |
probably damaging |
Het |
| Zfp831 |
A |
G |
2: 174,489,994 (GRCm39) |
K1254E |
possibly damaging |
Het |
|
| Other mutations in Zfp873 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
G1Funyon:Zfp873
|
UTSW |
10 |
81,896,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0666:Zfp873
|
UTSW |
10 |
81,896,595 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1568:Zfp873
|
UTSW |
10 |
81,896,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1739:Zfp873
|
UTSW |
10 |
81,896,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1848:Zfp873
|
UTSW |
10 |
81,896,406 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1892:Zfp873
|
UTSW |
10 |
81,897,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2061:Zfp873
|
UTSW |
10 |
81,895,991 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Zfp873
|
UTSW |
10 |
81,897,015 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4422:Zfp873
|
UTSW |
10 |
81,896,708 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4674:Zfp873
|
UTSW |
10 |
81,895,814 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4839:Zfp873
|
UTSW |
10 |
81,896,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5146:Zfp873
|
UTSW |
10 |
81,896,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5154:Zfp873
|
UTSW |
10 |
81,896,025 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R5160:Zfp873
|
UTSW |
10 |
81,896,876 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R5811:Zfp873
|
UTSW |
10 |
81,896,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6625:Zfp873
|
UTSW |
10 |
81,896,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6667:Zfp873
|
UTSW |
10 |
81,896,423 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6742:Zfp873
|
UTSW |
10 |
81,894,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6878:Zfp873
|
UTSW |
10 |
81,896,529 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7055:Zfp873
|
UTSW |
10 |
81,895,832 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7296:Zfp873
|
UTSW |
10 |
81,897,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7381:Zfp873
|
UTSW |
10 |
81,896,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Zfp873
|
UTSW |
10 |
81,896,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7464:Zfp873
|
UTSW |
10 |
81,896,210 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7470:Zfp873
|
UTSW |
10 |
81,895,773 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7640:Zfp873
|
UTSW |
10 |
81,896,109 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7862:Zfp873
|
UTSW |
10 |
81,896,109 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8017:Zfp873
|
UTSW |
10 |
81,896,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8301:Zfp873
|
UTSW |
10 |
81,896,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8765:Zfp873
|
UTSW |
10 |
81,896,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8997:Zfp873
|
UTSW |
10 |
81,896,990 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9305:Zfp873
|
UTSW |
10 |
81,896,514 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9462:Zfp873
|
UTSW |
10 |
81,897,131 (GRCm39) |
missense |
probably benign |
0.31 |
|
Z1177:Zfp873
|
UTSW |
10 |
81,896,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation